Patents by Inventor Yuichi Inai
Yuichi Inai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5104996Abstract: 2,3,5-trimethyl-benzoquinone is produced by oxidizing 2,3,6-trimethyl-phenol in the presence of a catalyst of cupric chloride and lithium chloride in a solvent mixture of an aromatic hydrocarbon and a lower aliphatic alcohol having 1 to 4 carbon atoms.Type: GrantFiled: May 11, 1988Date of Patent: April 14, 1992Assignee: Eisai Co., Ltd.Inventors: Noriyasu Hirose, Kimio Hamamura, Yuichi Inai, Kiiti Ema, Takashi Banba, Shizumasa Kijima
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Patent number: 4988732Abstract: A novel compound, 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid, and a salt thereof are disclosed together with a number of different processes for the preparation of the compound. The uses of the novel compound as an agent for treating papillomata are also disclosed.Type: GrantFiled: March 30, 1981Date of Patent: January 29, 1991Assignee: Eisai Co., Ltd.Inventors: Isao Yamatsu, Yuichi Inai, Shinya Abe, Takeshi Suzuki, Yoshikazu Suzuki, Osamu Tagaya, Kouichi Suzuki, Koichi Abe, Kouji Yamada
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Patent number: 4954525Abstract: Skin diseases with keratinization and allergic or inflammatory skin diseases are treated by orally or parenterally administering to an adult human patient from 40 mg to 4 g/day of a polyprenyl compound having the formula (I): ##STR1## in which each of n and m is 0, 1, or 2, n+m is 0, 1 or 2, A is ##STR2## and B is ##STR3## [in which R represents the hydroxyl group, a lower alkoxy group, or ##STR4## (wherein each of R.sub.1 and R.sub.Type: GrantFiled: May 6, 1981Date of Patent: September 4, 1990Assignee: Eisai Co., Ltd.Inventors: Isao Yamatsu, Yuichi Inai, Shinya Abe, Takeshi Suzuki, Yoshikazu Suzuki, Osamu Tagaya, Kouichi Suzuki, Kouichi Abe, Kouji Yamada
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Patent number: 4917829Abstract: A novel compound, 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid, and a salt thereof are disclosed together with a number of different processes for the preparation of the compound. The uses of the novel compound as an anticancer agent are also disclosed.Type: GrantFiled: May 16, 1986Date of Patent: April 17, 1990Assignee: Eisai Co., Ltd.Inventors: Isao Yamatsu, Yuichi Inai, Shinya Abe, Takeshi Suzuki, Yoshikazu Suzuki, Osamu Tagaya, Kouichi Suzuki, Koichi Abe, Kouji Yamada
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Patent number: 4835183Abstract: An anti-cancer agent which comprises a polyprenvl compound having the formula (I): ##STR1## in which each of n and m is 0, 1 or 2, n+m is 0, 1 or 2, A is ##STR2## and B is ##STR3## in which R represents the hydroxyl group, a lower alkoxy group, or ##STR4## (wherein each of R.sub.1 and R.sub.Type: GrantFiled: December 20, 1982Date of Patent: May 30, 1989Assignee: Eisai Co., Ltd.Inventors: Isao Yamatsu, Yuichi Inai, Shinya Abe, Takeshi Suzuki, Yoshikazu Suzuki, Osamu Tagaya, Kouichi Suzuki, Kouichi Abe, Kouji Yamada
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Patent number: 4709079Abstract: Non-steroidal, anti-inflammatory drugs are disclosed which are polyprenyl alcohol esters of indolyl lower carboxylic acids, phenyl lower carboxylic acids, acetyl salicyclic acid, anthranilic acid and derivatives thereof.Type: GrantFiled: January 17, 1986Date of Patent: November 24, 1987Assignee: Eisai Co., Ltd.Inventors: Isao Yamatsu, Shinya Abe, Yuichi Inai, Takeshi Suzuki, Kensaku Kinoshita, Mannen Mishima, Yoshinori Katoh, Seiichi Kobayashi, Manabu Murakami, Kouzi Yamada
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Patent number: 4655973Abstract: A conjugated polyprenylcarboxylic acid and its derivative having the formula: ##STR1## in which each of n and m is 0, 1 or 2, n+m is 1 or 2, A is ##STR2## and R is the hydroxyl group, a lower alkoxy group or ##STR3## wherein each of R.sub.1 and R.sub.2 represents the hydrogen atom, a lower alkyl group, or an aryl group; provided that R is ##STR4## if A is ##STR5## n is 1 and m is 0.Type: GrantFiled: May 6, 1981Date of Patent: April 7, 1987Assignee: Eisai Co., Ltd.Inventors: Isao Yamatsu, Yuichi Inai, Shinya Abe, Takeshi Suzuki, Yoshikazu Suzuki, Osamu Tagaya, Kouichi Suzuki, Kouichi Abe, Kouji Yamada
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Patent number: 4639450Abstract: This invention relates to polyprenylcarboxylic acid amides represented by the following general formula (I): ##STR1## wherein n is an integer of from 1 to 4, a and b stand for hydrogen atoms or a direct valence bond between the carbon atoms to which a and b are attached, c and d stand for hydrogen atoms or a direct valence bond between the carbon atoms to which c and d are attached, and R.sub.1 and R.sub.2 stand for a hydrogen atom, a lower alkyl group, a phenyl group which may be substituted or an aralkyl group which may be substituted, or R.sub.1 and R.sub.2 form, together with the adjacent nitrogen atom, a 5- or 6-membered heterocyclic ring which may contain other hetero atoms or may be substituted,and also to a process for the preparation of said polyprenylcarboxylic acid amide and to a pharmaceutical composition for treating liver dysfunction comprising said polyprenylcarboxylic acid amide.Type: GrantFiled: December 4, 1984Date of Patent: January 27, 1987Assignee: Eisai Co., Ltd.Inventors: Isao Yamatsu, Yuichi Inai, Shinya Abe, Hideaki Watanabe, Toshiji Igarashi, Hiroyuki Shiojiri, Yoshio Tanabe, Kumiko Hara
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Patent number: 4576963Abstract: Non-steroidal, anti-inflammatory drugs are disclosed which are polyprenyl alcohol esters of indolyl lower carboxylic acids, phenyl lower carboxylic acids, acetyl salicylic acid, anthranilic acid and derivatives thereof.Type: GrantFiled: May 14, 1984Date of Patent: March 18, 1986Assignee: Eisai Co., Ltd.Inventors: Isao Yamatsu, Shinya Abe, Yuichi Inai, Takeshi Suzuki, Kensaku Kinoshita, Mannen Mishima, Yoshinori Katoh, Seiichi Kobayashi, Manabu Murakami, Kouzi Yamada
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Patent number: 4571408Abstract: An .alpha.,.beta.-dihydropolyprenyl derivative having the formula (I): ##STR1## wherein X represents a group of --COOR.sub.1 or --CH.sub.2 OR.sub.2 in which R.sub.1 is the hydrogen atom or an alkyl group having one to four carbon atoms and R.sub.2 is the hydrogen atom or an aliphatic acyl group having one to four carbon atoms; and n is an integer of one to four. A process for the preparation of the .alpha.,.beta.-dihydropolyprenyl derivative and a therapeutic agent for treatment of liver diseases comprising the same are also disclosed.Type: GrantFiled: October 20, 1983Date of Patent: February 18, 1986Assignee: Eisai Co., Ltd.Inventors: Isao Yamatsu, Yuichi Inai, Shinya Abe, Hideaki Watanabe, Toshiji Igarashi, Hiroyuki Shiojiri, Yoshio Tanabe, Kuniko Hara
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Patent number: 4500463Abstract: Polyprenyl carboxylic acid derivatives having the general formula (I): ##STR1## in which n is an integer of from 2 to 4, R.sub.1 represents the hydrogen atom or a protecting group for the carboxylic acid group, and R.sub.2 represents a hydroxymethyl, formyl or carboxyl group, are disclosed. A process for the preparation of the polyprenyl carboxylic acid derivative involving microbiological oxidation using a strain belonging to the genus Nocardia is disclosed. The compounds have anti-ulcer activity and hypotensive activity. The compounds also are useful as intermediates for preparing polyprenyl carboxylic acids of the formula ##STR2## and esters thereof, wherein l is an integer of from 4 to 11. The polyprenyl carboxylic acids and esters thereof have hypotensive activity and anti-ulcer activity.Type: GrantFiled: May 1, 1981Date of Patent: February 19, 1985Assignees: Eisai Co., Ltd., Agency of Industrial Science & TechnologyInventors: Akio Sato, Kenji Nakajima, Yoshimasa Takahara, Shizumasa Kijima, Yuichi Inai, Yoshiyuki Kohara, Yoshiyuki Kawakami, Tomio Tsurugi
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Patent number: 4482734Abstract: The polyprenyl compound having the formula: ##STR1## wherein X represents a group of the formula: --CH.dbd.CH--, a group of the formula: ##STR2## or a group of the formula: ##STR3## and Y represents a group of the formula: --COOR.sup.1 in which R.sup.1 represents a hydrogen atom or a lower alkyl group or a group of the formula: ##STR4## in which R.sup.2 represents a hydrogen atom or a lower alkyl group, is new and useful as a medicine.Type: GrantFiled: June 16, 1983Date of Patent: November 13, 1984Assignee: Eisai Co., Ltd.Inventors: Isao Yamatsu, Takeshi Suzuki, Shinya Abe, Yuichi Inai, Yoshikazu Suzuki, Osamu Tagaya
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Patent number: 4481217Abstract: An .alpha.,.beta.-dihydropolyprenyl derivative having the formula (I): ##STR1## wherein X represents a group of --COOR.sub.1 or --CH.sub.2 OR.sub.2 in which R.sub.1 is the hydrogen atom or a lower alkyl group and R.sub.2 is the hydrogen atom or an aliphatic acyl group having one to four carbon atoms; and n is an integer of one to four. A process for the preparation of the .alpha.,.beta.-dihydropolyprenyl derivative and a therapeutic agent for treatment of liver diseases comprising the same are also disclosed.Type: GrantFiled: May 28, 1981Date of Patent: November 6, 1984Assignee: Eisai Co., Ltd.Inventors: Isao Yamatsu, Yuichi Inai, Shinya Abe, Hideaki Watanabe, Toshiji Igarashi, Hiroyuki Shiojiri, Yoshio Tanabe, Kuniko Hara
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Patent number: 4474881Abstract: A process is disclosed for the preparation of a compound having the general formula: ##STR1## wherein n is an integer of from 2 to 4, R.sub.1 is an ester-forming moiety effective as a protecting group for a carboxyl group, and R.sub.2 is hydroxymethyl, formyl or carboxyl. The compounds (I) are useful as intermediates for the preparation of polyprenyl compounds having hypotensive and anti-ulcer activity. The process of the invention includes cultivating a microorganism selected from a strain of the genus Nocardia called BPM 1613, FERM-P No. 1609, Corynebacterium equi IAM 1038, Candida lipolytica IFO 0746, and Mycobacterium smegmatis IFO 3083, in a nutritive culture medium, in the presence of a compound having the general formula: ##STR2## wherein R.sub.3 is an ester-forming moiety effective as a protecting group for a carboxyl group, whereby the microorganism utilizes the compound (II) as a carbon source and oxidizes the compound (II), thereby converting the compound (II) into the compound (I).Type: GrantFiled: June 28, 1982Date of Patent: October 2, 1984Assignees: Eisai Co., Ltd., Agency of Industrial Science and TechnologyInventors: Akio Sato, Kenji Nakajima, Yoshimasa Takahara, Shizumasa Kijima, Yuichi Inai, Yoshiyuki Kohara, Yoshiyuki Kawakami, Tomio Tsurugi
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Patent number: 4456603Abstract: Polyprenyl carboxylic acid amides of the formula ##STR1## process for their preparation and use thereof for treating liver dysfunction are disclosed.Type: GrantFiled: August 4, 1980Date of Patent: June 26, 1984Assignee: Eisai Co., Ltd.Inventors: Isao Yamatsu, Yuichi Inai, Shinya Abe, Hideaki Watanabe, Toshiji Igarashi, Hiroyuki Shiojiri, Yoshio Tanabe, Kumiko Hara
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Patent number: 4455316Abstract: Non-steroidal, anti-inflammatory drugs are disclosed which are polyprenyl alcohol esters of indolyl lower carboxylic acids, phenyl lower carboxylic acids, acetyl salicylic acid, anthranilic acid and derivatives thereof.Type: GrantFiled: July 8, 1982Date of Patent: June 19, 1984Assignee: Eisai Co., Ltd.Inventors: Isao Yamatsu, Shinya Abe, Yuichi Inai, Takeshi Suzuki, Kensaku Kinoshita, Mannen Mishima, Yoshinori Katoh, Seiichi Kobayashi, Manabu Murakami, Kouzi Yamada
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Patent number: 4454126Abstract: Phosphoramide derivatives of the general formula: ##STR1## are disclosed wherein X and Y each represents a hydrogen atom or X and Y are removed to form a double bond between the respective adjoining carbon atoms, and n represents an integer of 0 to 2. A process for the preparation of these compounds and pharmaceutical compositions containing these phosphoramide derivatives are also disclosed. The phosphoramide derivatives of the invention are used to treat urethral calculosis and pyelonephritis.Type: GrantFiled: October 15, 1982Date of Patent: June 12, 1984Assignee: Eisai Co., Ltd.Inventors: Isao Yamatsu, Yuichi Inai, Takeshi Suzuki, Shinya Abe, Masaru Satoh, Naosuke Seto
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Patent number: 4382151Abstract: 6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraene-2-ols of the general formula: ##STR1##Type: GrantFiled: August 27, 1981Date of Patent: May 3, 1983Assignee: Eisai Co., Ltd.Inventors: Isao Yamatsu, Yuichi Inai, Shinya Abe, Takeshi Suzuki, Toshiharu Ohgoh, Manabu Murakami, Kiyoshi Oketani, Hideaki Fujisaki
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Patent number: 4346109Abstract: A compound, 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid, and a salt thereof are disclosed as a therapeutic agent for treatment of skin diseases with keratinization.Type: GrantFiled: March 30, 1981Date of Patent: August 24, 1982Assignee: Eisai Co., Ltd.Inventors: Isao Yamatsu, Yuichi Inai, Shinya Abe, Takeshi Suzuki, Yoshikazu Suzuki, Osamu Tagaya, Nozomu Koyanagi
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.beta., .gamma.-Dihydropolyprenyl alcohol and hypotensive pharmaceutical composition containing same
Patent number: 4325974Abstract: .beta., .gamma.-Dihydropolyprenyl alcohols of the general formula: ##STR1## wherein n represents an integer of 8 to 10, exhibit hypotensive activity and anti-hepatic disease-activity.Type: GrantFiled: November 21, 1979Date of Patent: April 20, 1982Assignee: Eisai Co., Ltd.Inventors: Isao Yamatsu, Shinya Abe, Yuichi Inai, Toshiji Igarashi, Yoshikage Nakajima