Patents by Inventor Yuichi Shiro

Yuichi Shiro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYMORPHIC FORM OF SEPIAPTERIN
    Publication number: 20220081443
    Abstract: Disclosed is a crystalline form of sepiapterin, a method of preparing the crystalline form, pharmaceutical compositions containing the crystalline form, and a method for treating patients with a disease associated with low intracellular BH4 levels or with dysfunction of various BH4 dependent metabolic pathways, which involves administering to the patient an effective amount of the crystalline form.
    Type: Application
    Filed: September 27, 2021
    Publication date: March 17, 2022
    Inventors: Hiroshi YOSHINO, Taichi KOMODA, Yuichi SHIRO, Shunichi MURATA, Takayoshi MATSUMOTO, Kaito KISHIMOTO, Daniel E. LEVY
  • Polymorphic form of sepiapterin
    Patent number: 11130760
    Abstract: Disclosed is a crystalline form of sepiapterin, a method of preparing the crystalline form, pharmaceutical compositions containing the crystalline form, and a method for treating patients with a disease associated with low intracellular BH4 levels or with dysfunction of various BH4 dependent metabolic pathways, which involves administering to the patient an effective amount of the crystalline form.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: September 28, 2021
    Assignee: PTC Therapeutics MP, Inc.
    Inventors: Hiroshi Yoshino, Taichi Komoda, Yuichi Shiro, Shunichi Murata, Takayoshi Matsumoto, Kaito Kishimoto, Daniel E. Levy
  • PHARMACEUTICALLY ACCEPTABLE SALTS OF SEPIAPTERIN
    Publication number: 20210269443
    Abstract: The present invention relates to new pharmaceutical salts and/or co-crystals of sepiapterin which exhibit improved properties. In particular, the invention relates to salts of sepiapterin with improved stability. The invention also relates to pharmaceutical compositions including a pharmaceutically effective amount of one or more salts and/or co-crystals of sepiapterin, as well as methods of treating tetrahydrobiopterin-related disorders including administration of a sepiapterin salt and/or co-crystal of the invention to a subject in need thereof.
    Type: Application
    Filed: May 30, 2019
    Publication date: September 2, 2021
    Inventors: Daniel E. LEVY, Neil SMITH, Jonathan REIS, Hiroshi YOSHINO, Taichi KOMODA, Yuichi SHIRO, Shunichi MURATA, Takayoshi MATSUMOTO, Kaito KISHIMOTO
  • POLYMORPHIC FORM OF SEPIAPTERIN
    Publication number: 20200010469
    Abstract: Disclosed is a crystalline form of sepiapterin, a method of preparing the crystalline form, pharmaceutical compositions containing the crystalline form, and a method for treating patients with a disease associated with low intracellular BII4 levels or with dysfunction of various BII4 dependent metabolic pathways, which involves administering to the patient an effective amount of the crystalline form.
    Type: Application
    Filed: November 28, 2017
    Publication date: January 9, 2020
    Inventors: Hiroshi YOSHINO, Taichi KOMODA, Yuichi SHIRO, Shunichi MURATA, Takayoshi MATSUMOTO, Kaito KISHIMOTO, Daniel E. LEVY
  • Method for producing sepiapterin and tetrahydrolactoylpterin
    Patent number: 9181254
    Abstract: To provide a method for producing sepiapterin, lactoylpterin or tetrahydrolactoylpterin. Sepiapterin, lactoylpterin and tetrahydrolactoylpterin are produced at high yield through the following reaction scheme.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: November 10, 2015
    Assignee: SHIRATORI PHARMACEUTICAL CO., LTD.
    Inventors: Hiroshi Yoshino, Taichi Komoda, Yuichi Shiro, Shunichi Murata, Shizuaki Murata, Yasuhiro Kuroda
  • METHOD FOR PRODUCING SEPIAPTERIN AND TETRAHYDROLACTOYLPTERIN
    Publication number: 20150119574
    Abstract: To provide a method for producing sepiapterin, lactoylpterin or tetrahydrolactoylpterin. Sepiapterin, lactoylpterin and tetrahydrolactoylpterin are produced at high yield through the following reaction scheme.
    Type: Application
    Filed: May 7, 2013
    Publication date: April 30, 2015
    Applicant: SHIRATORI PHARMACEUTICAL CO., LTD.
    Inventors: Hiroshi Yoshino, Taichi Komoda, Yuichi Shiro, Shunichi Murata, Shizuaki Murata, Yasuhiro Kuroda
  • Method for producing hydrazone derivatives
    Patent number: 7582799
    Abstract: The present invention provides an industrially advantageous process for producing hydrazone derivative represented by the formula (5), which is shown by the following reaction formula.
    Type: Grant
    Filed: April 27, 2006
    Date of Patent: September 1, 2009
    Assignees: Shiratori Pharmaceutical Co., Ltd., Asubio Pharma Co., Ltd.
    Inventors: Hiroshi Yoshino, Kentaro Kobayashi, Yuichi Shiro
  • METHOD FOR PRODUCING HYDRAZONE DERIVATIVES
    Publication number: 20090076305
    Abstract: The present invention provides an industrially advantageous process for producing hydrazone derivative represented by the formula (5), which is shown by the following reaction formula.
    Type: Application
    Filed: April 27, 2006
    Publication date: March 19, 2009
    Applicants: Shiratori Pharmaceutical Co., Ltd., Asubio Pharma Co., Ltd.
    Inventors: Hiroshi Yoshino, Kentaro Kobayashi, Yuichi Shiro