Abstract: A stable, storable pharmaceutical composition is provided which comprises a dehydrated solid mixture of microbial cell wall skeleton, vehicle oil, suspending agent and dispersing agent; wherein said microbial cell wall skeleton has adjuvant and antitumor activity. The composition is easily prepared, stable to long term storage, and easily reconstituted to form a homogeneous suspension which retains high potency.

Abstract: A method for treating and preventing bacterial infections which comprises administering a 6-O-acylmuramyl depeptide of the formula: ##STR1## wherein X represents a divalent residual group of an amino acid such as L-alanine, L-serine, L-valine, etc., Y represents a residual group of a middle to higher fatty acid having 10 to 60 carbon atoms and isoGln represents a residual group of isoglutamine, or a pharmaceutical composition containing a 6-O-acylmuramyl dipeptide of the formula(I) as an active ingredient to a patient afflicted therewith.

Abstract: Novel glucosamine-peptide derivatives of the formula: ##STR1## wherein m is 0 or 1;n is 0 or an integer of 1 to 9;R is lower alkyl which may be substituted with hydroxyl, or aryl;R.sup.1 is hydrogen or acyl having an acyclic hydrocarbon group, the terminal of which may be substituted with a cyclic hydrocarbon group directly, via a carbonyl group or via an oxygen atom;provided that when R.sup.1 is hydrogen m is 1;R.sup.2 is hydrogen or lower alkyl which may form a ring by connecting its terminal with the .alpha.-nitrogen atom whenn is 0, or hydrogen when n is an integer of 1 to 9;R.sup.3 is hydrogen or lower alkyl;R.sup.4 and R.sup.5 are each hydrogen or lower alkyl which may be substituted with hydroxyl or benzyloxyl;R.sup.6 is hydrogen or lower alkyl;R.sup.7 is alkyl which may be substituted with lower alkoxyl or aralkyl;R.sup.8 and R.sup.

Abstract: A method for treating peripheral orthostatic hypotension which comprises administering DL- or L-threo-3,4-dihydroxyphenylserine or a pharmaceutically acceptable acid addition salt thereof to a subject suffering from the disease. The composition may be administered either orally or parenterally.

Abstract: Muramyldipeptide derivatives of the formula (I): ##STR1## wherein X represents an amino acid residue such as of L-alanine, L-serine, L-valine, glycine, etc., and Y represents a group ##STR2## wherein R.sub.1 represents a hydrogen atom, an alkyl group of 1 to 6 carbon atoms, a carboxamide group or a carboxyl group, n represents an integer of 1 to 6, A represents a straight or branched chain, saturated or unsaturated aliphatic hydrocarbon residue of 7 to 30 carbon atoms, and "Acyl" means an acyl group of an aliphatic carboxylic acid having 2 to 6 carbon atoms. These compounds have excellent adjuvant activity and/or prophylactic and therapeutic effects against microbial infections.

Abstract: Novel 6-deoxyglucosamine-peptide derivatives of the formula ##STR1## wherein R is hydrogen or an organic acid residue or alkoxycarbonyl;R.sup.1 is hydrogen or acyl;R.sup.2 is hydrogen or lower alkyl;R.sup.3 and R.sup.4 are each hydrogen or lower alkyl which may be substituted with hydroxyl;R.sup.5 and R.sup.6 are each carboxyl which may be esterified or amidated;R.sup.7 is hydrogen or aralkyl; and(D) and (L) each indicate configurations if theirrespective carbon atoms are asymmetric or a salt thereof having immunostimulatory activity.

Abstract: A composition which is capable of specifically inducing an immunity when administered into the body of a host in association with a tumor antigen, or which is capable of non-specifically enhancing an immunizing function when administered into the body of a tumor-carrying host, comprising a glycolipid as active ingredient in association with a pharmaceutically acceptable carrier, wherein the saccharide moiety of the glycolipid is selected from the group consisting of fructose, glucose and sucrose.

Abstract: The aqueous preparation such as an aqueous solution, a water-in-oil emulsion, in which a water-soluble salt of the quinonyl acid derivative of the formula: ##STR1## [wherein each R is a lower alkoxy group having 1 to 4 carbon atoms or the two R's, taken together, represent a group of --CH.dbd.CH--CH.dbd.CH--; --A--COOH means ##STR2## when both R's are lower alkoxy groups, or --(CH.sub.2).sub.n COOH (wherein n is an integer from 1 to 8) when two R's, taken together, represent a group of --CH.dbd.CH--CH.dbd.CH--] is dissolved in aqueous phase, shows an excellent immunoregulatory activity in animals including human being.

Abstract: Muramyldipeptide derivatives of the formula: ##STR1## wherein Y represents a mycoloyl group or a synthetic higher acyl group having total carbon number of C30-C90 and having at least a branched chain of long alkyl group on the .alpha.-position thereof,Q represents an -L-alanyl-D-isoglutamine group, a -glycyl-D-isoglutamine group or an -L-seryl-D-isoglutamine group;Salts of such derivatives; the method of preparing such derivatives and their salts; the derivatives and their salts having potent immunoadjuvant activities and antitumor activity and being applicable as the agent for the immunotherapy of cancer for humans and animals.