Abstract: The present invention provides a compound having a Pim-1 inhibitory activity. The present invention provides a compound of Formula [I] or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the same, and a pharmaceutical use thereof, and the like. wherein each symbol is as defined in the description.

Abstract: The method for controlling flow pattern of molten steel in continuous casting, comprises the steps of: (a) continuously casting a molten steel injected through an immersion nozzle; (b) measuring temperatures of a copper plate on longer side of the mold in width direction thereof at plurality of points; (c) detecting a flow pattern of the molten steel in the mold based on the time-sequential variations of temperatures of the copper plate at individual measurement points; and (d) controlling the flow pattern to establish a specified pattern on the basis of the detected result. The temperatures of mold copper plate are measured by plurality of temperature measurement elements buried in the rear face of the mold copper plate for continuous casting. The temperature measurement elements are arranged in a range of from 10 to 135 mm distant from the melt surface in the mold in the slab-drawing direction.

Abstract: An immersion nozzle for continuous casting have an immersion nozzle body, at least one opening hole for receiving the molten metal, a vertical bore, at least one pair of exit ports for introducing the molten metal into the mold through the vertical bore, a slit opening for introducing the molten metal downwardly and a downwardly convex surface of the bottom of the vertical bore.The slit opening is located at a bottom end of the body of said immersion nozzle which is below the exit ports and in parallel to the width direction of the mold.