Patents by Inventor Yuji Itose
Yuji Itose has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10794809Abstract: The present invention relates to a method for analyzing urine sample, a reagent for the analysis of a urine sample and a reagent kit for the analysis of a urine sample, which are used for detecting at least casts and erythrocytes as urinary particles.Type: GrantFiled: February 27, 2015Date of Patent: October 6, 2020Assignee: SYSMEX CORPORATIONInventors: Akinori Kawai, Yuji Itose
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Patent number: 9891210Abstract: This blood analyzer includes a sample preparation portion preparing a measurement sample free from a labeling substance from a blood sample and a hemolytic agent free from a labeling substance, a light information generation portion generating fluorescent information and at least two types of scattered light information from the measurement sample and a control portion performing a first classification of white blood cells in the measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of the fluorescent information and the two types of scattered light information.Type: GrantFiled: July 8, 2014Date of Patent: February 13, 2018Assignee: SYSMEX CORPORATIONInventors: Hideaki Matsumoto, Kinya Uchihashi, Yuji Itose, Aya Konishi
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Publication number: 20160363521Abstract: The present invention relates to a method for analyzing urine sample, a reagent for analysis of urine sample and a reagent kit for analysis of urine sample, which are for detecting at least casts and erythrocytes as urinary particles.Type: ApplicationFiled: February 27, 2015Publication date: December 15, 2016Applicant: SYSMEX CORPORATIONInventors: Akinori KAWAI, Yuji ITOSE
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Patent number: 9328375Abstract: This blood analyzer includes a sample preparation portion preparing a first measurement sample containing a blood sample and a hemolytic agent and a second measurement sample containing the blood sample, the same hemolytic agent as the hemolytic agent and a staining agent and a control portion classifying white blood cells in the first measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of fluorescent information and two types of scattered light information generated by a light information generation portion and classifying blood cells in the second measurement sample into at least malaria-infected red blood cells and others on the basis of fluorescent information and scattered light information generated by the light information generation portion.Type: GrantFiled: November 3, 2014Date of Patent: May 3, 2016Assignee: SYSMEX CORPORATIONInventors: Hideaki Matsumoto, Kinya Uchihashi, Yuji Itose, Aya Konishi, Ayumu Yoshida
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Publication number: 20150050643Abstract: This blood analyzer includes a sample preparation portion preparing a first measurement sample containing a blood sample and a hemolytic agent and a second measurement sample containing the blood sample, the same hemolytic agent as the hemolytic agent and a staining agent and a control portion classifying white blood cells in the first measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of fluorescent information and two types of scattered light information generated by a light information generation portion and classifying blood cells in the second measurement sample into at least malaria-infected red blood cells and others on the basis of fluorescent information and scattered light information generated by the light information generation portion.Type: ApplicationFiled: November 3, 2014Publication date: February 19, 2015Applicant: SYSMEX CORPORATIONInventors: Hideaki MATSUMOTO, Kinya UCHIHASHI, Yuji ITOSE, Aya KONISHI, Ayumu YOSHIDA
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Patent number: 8920726Abstract: This blood analyzer includes a sample preparation portion preparing a first measurement sample containing a blood sample and a hemolytic agent and a second measurement sample containing the blood sample, the same hemolytic agent as the hemolytic agent and a staining agent and a control portion classifying white blood cells in the first measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of fluorescent information and two types of scattered light information generated by a light information generation portion and classifying blood cells in the second measurement sample into at least malaria-infected red blood cells and others on the basis of fluorescent information and scattered light information generated by the light information generation portion.Type: GrantFiled: November 9, 2010Date of Patent: December 30, 2014Assignee: Sysmex CorporationInventors: Hideaki Matsumoto, Kinya Uchihashi, Yuji Itose, Aya Konishi, Ayumu Yoshida
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Publication number: 20140322750Abstract: This blood analyzer includes a sample preparation portion preparing a measurement sample free from a labeling substance from a blood sample and a hemolytic agent free from a labeling substance, a light information generation portion generating fluorescent information and at least two types of scattered light information from the measurement sample and a control portion performing a first classification of white blood cells in the measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of the fluorescent information and the two types of scattered light information.Type: ApplicationFiled: July 8, 2014Publication date: October 30, 2014Applicant: SYSMEX CORPORATIONInventors: Hideaki MATSUMOTO, Kinya UCHIHASHI, Yuji ITOSE, Aya KONISHI
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Patent number: 8808624Abstract: This blood analyzer includes a sample preparation portion preparing a measurement sample free from a labeling substance from a blood sample and a hemolytic agent free from a labeling substance, a light information generation portion generating fluorescent information and at least two types of scattered light information from the measurement sample and a control portion performing a first classification of white blood cells in the measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of the fluorescent information and the two types of scattered light information.Type: GrantFiled: November 9, 2010Date of Patent: August 19, 2014Assignee: Sysmex CorporationInventors: Hideaki Matsumoto, Kinya Uchihashi, Yuji Itose, Aya Konishi
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Patent number: 8802025Abstract: The present invention provides a reagent kit for analyzing a sample comprising a first reagent containing a cationic surfactant, a nonionic surfactant and an aromatic carboxylic acid and a second reagent containing a fluorescent dye capable of staining nucleic acid, and a method for analyzing a sample using the kit.Type: GrantFiled: September 26, 2008Date of Patent: August 12, 2014Assignee: Sysmex CorporationInventors: Tatsuya Narikawa, Tomohiro Tsuji, Keiko Moriyama, Yuji Itose, Shinichiro Oguni, Ayumu Yoshida, Saori Suzuki, Toshihiro Mizukami
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Patent number: 8679425Abstract: A reagent container set is disclosed which comprises: a first reagent container for accommodating a first reagent to be used in a sample analyzer, the top part of the first reagent container having a first aspiration opening for inserting a first reagent aspirating tube to aspirate the first reagent; a waste fluid container for accommodating the first reagent used in the sample analyzer as a waste fluid, the top of the waste fluid container having a discharge opening for inserting a waste fluid discharging tube to discharge the waste fluid into the waste fluid container; a box for accommodating the first reagent container and the waste fluid container; and a container holding member for holding the first reagent container and the waste fluid container so that the first aspiration opening and the discharge opening are disposed at predetermined positions, the container holding member being maintained at a predetermined position within the box.Type: GrantFiled: July 16, 2010Date of Patent: March 25, 2014Assignee: Sysmex CorporationInventors: Sachiko Ueda, Yusuke Mori, Hiroyuki Ohashi, Yuji Itose, Kinya Uchihashi, Yoichi Nakamura, Kohei Sugitani
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Publication number: 20110053212Abstract: This blood analyzer includes a sample preparation portion preparing a first measurement sample containing a blood sample and a hemolytic agent and a second measurement sample containing the blood sample, the same hemolytic agent as the hemolytic agent and a staining agent and a control portion classifying white blood cells in the first measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of fluorescent information and two types of scattered light information generated by a light information generation portion and classifying blood cells in the second measurement sample into at least malaria-infected red blood cells and others on the basis of fluorescent information and scattered light information generated by the light information generation portion.Type: ApplicationFiled: November 9, 2010Publication date: March 3, 2011Applicant: SYSMEX CORPORATIONInventors: Hideaki Matsumoto, Kinya Uchihashi, Yuji Itose, Aya Konishi, Ayumu Yoshida
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Publication number: 20110053210Abstract: This blood analyzer includes a sample preparation portion preparing a measurement sample free from a labeling substance from a blood sample and a hemolytic agent free from a labeling substance, a light information generation portion generating fluorescent information and at least two types of scattered light information from the measurement sample and a control portion performing a first classification of white blood cells in the measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of the fluorescent information and the two types of scattered light information.Type: ApplicationFiled: November 9, 2010Publication date: March 3, 2011Applicant: SYSMEX CORPORATIONInventors: Hideaki MATSUMOTO, Kinya Uchihashi, Yuji Itose, Aya Konishi
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Publication number: 20110014095Abstract: A reagent container set is disclosed which comprises: a first reagent container for accommodating a first reagent to be used in a sample analyzer, the top part of the first reagent container having a first aspiration opening for inserting a first reagent aspirating tube to aspirate the first reagent; a waste fluid container for accommodating the first reagent used in the sample analyzer as a waste fluid, the top of the waste fluid container having a discharge opening for inserting a waste fluid discharging tube to discharge the waste fluid into the waste fluid container; a box for accommodating the first reagent container and the waste fluid container; and a container holding member for holding the first reagent container and the waste fluid container so that the first aspiration opening and the discharge opening are disposed at predetermined positions, the container holding member being maintained at a predetermined position within the box.Type: ApplicationFiled: July 16, 2010Publication date: January 20, 2011Inventors: Sachiko UEDA, Yusuke Mori, Hiroyuki Ohashi, Yuji Itose, Kinya Uchihashi, Yoichi Nakamura, Kohei Sugitani
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Publication number: 20100330565Abstract: The present invention provides a reagent kit for analyzing a sample comprising a first reagent containing a cationic surfactant, a nonionic surfactant and an aromatic carboxylic acid and a second reagent containing a fluorescent dye capable of staining nucleic acid, and a method for analyzing a sample using the kit.Type: ApplicationFiled: September 26, 2008Publication date: December 30, 2010Applicant: Sysmex CorporationInventors: Tatsuya Narikawa, Tomohiro Tsuji, Keiko Moriyama, Yuji Itose, Shinichiro Oguni, Ayumu Yoshida, Saori Suzuki, Toshihiro Mizukami
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Publication number: 20090246805Abstract: A method for counting basophils which comprises: (1) mixing and reacting a blood sample with an anti-CD123 antibody labeled with a first fluorescent label and an anti-CD294 antibody labeled with a second fluorescent label to prepare a measurement sample, (2) introducing the measurement sample into a flow cell of a flow cytometer and irradiating, with light, cells in the measurement sample flowing in the flow cell, (3) detecting fluorescences from the first and second fluorescent labels as well as two scattered lights different in angle, emitted from the cells, (4) identifying basophils on the basis of the detected fluorescences from the first and second fluorescent labels as well as the two scattered lights different in angle, and (5) counting the identified basophils. A kit for measuring basophils which comprises a CD123 antibody labeled with a first fluorescent label and a CD294 antibody labeled with a second fluorescent label.Type: ApplicationFiled: March 11, 2009Publication date: October 1, 2009Applicant: SYSMEX CORPORATIONInventors: Keiko Moriyama, Yuji Itose, Tatsuya Narikawa
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Patent number: 7354775Abstract: A reagent for partially lysing a cell membrane of a red blood cell infected with a malaria parasite, comprising: a first surfactant which has predetermined lysing ability for the red blood cell membrane; and a second surfactant which has weaker lysing ability than that of the first surfactant; wherein the reagent has pH of 5 to 7 and osmotic pressure of 200 to 300 mOsm/kg·H2O; and wherein the reagent partially lyses the malaria infected red blood cell membrane such that a malaria parasite is retained in the red blood cell and fluorescent dye passes through the cell membrane, is disclosed. A reagent for detecting malaria infected red blood cells, and a sample analyzing method for detecting malaria infected red blood cells, are also disclosed.Type: GrantFiled: March 28, 2006Date of Patent: April 8, 2008Assignee: Sysmex CorporationInventors: Ayumu Yoshida, Kinya Uchihashi, Yuji Itose, Aya Konishi, Hiromitsu Iizuka
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Publication number: 20070020721Abstract: A blood analyzing method is described that includes steps of: preparing a measurement sample by hemolyzing red blood cells in a blood specimen, the measurement sample containing particles; irradiating a light on the measurement sample to detect two or more types of optical information reflecting characters of the particles in the measurement sample, thereby acquiring data indicating light intensities of the respective optical information as a particle data associated with each of the particles; counting white blood cells based on the particle data; outputting the result of counting white blood cells; determining whether malarial parasites are present or not based on the particle data; and outputting the result of determining. A blood analyzer also described.Type: ApplicationFiled: July 21, 2006Publication date: January 25, 2007Inventors: Ayumu Yoshida, Yuji Itose, Kinya Uchihashi
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Publication number: 20060223137Abstract: A reagent for partially lysing a cell membrane of a red blood cell infected with a malaria parasite, comprising: a first surfactant which has predetermined lysing ability for the red blood cell membrane; and a second surfactant which has weaker lysing ability than that of the first surfactant; wherein the reagent has pH of 5 to 7 and osmotic pressure of 200 to 300 mOsm/kg·H2O; and wherein the reagent partially lyses the malaria infected red blood cell membrane such that a malaria parasite is retained in the red blood cell and fluorescent dye passes through the cell membrane, is disclosed. A reagent for detecting malaria infected red blood cells, and a sample analyzing method for detecting malaria infected red blood cells, are also disclosed.Type: ApplicationFiled: March 28, 2006Publication date: October 5, 2006Inventors: Ayumu Yoshida, Kinya Uchihashi, Yuji Itose, Aya Konishi, Hiromitsu Iizuka
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Publication number: 20030219850Abstract: An automatic method for analyzing nucleated bone marrow cells comprising partitioning one sample of bone marrow fluid with two samples, one sample being treated with a first lysing agent and a first staining solution and the other sample being treated with a second lysing agent and a second staining solution; andType: ApplicationFiled: May 13, 2003Publication date: November 27, 2003Applicant: Sysmex CorporationInventors: Tomohiro Tsuji, Yuji Itose, Aya Konishi
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Patent number: 6067158Abstract: A method for detecting abnormality in the morphology of erythrocytes, which comprises:(1) mixing a sample containing erythrocytes with a sphere-forming reagent;(2) introducing the sample treated in the preceding step into a detector area of a flow cytometer;(3) measuring at least one scattered light at an angle reflecting the morphology of erythrocyte among the scattered lights emitted from the sample to obtain cell distribution data; and(4) comparing the cell distribution data with cell distribution data on normal erythrocytes that were determined beforehand.Type: GrantFiled: April 27, 1998Date of Patent: May 23, 2000Assignee: Sysmex CorporationInventors: Yuji Itose, Kayo Hatanaka, Tomohiro Sakurai