Patents by Inventor Yuji Kashiwakura

Yuji Kashiwakura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cancer cell death inducing agent having effects of potentiating anticancer drug against anticancer-drug-resistant cancer
    Patent number: 8946173
    Abstract: The present invention provides a drug capable of causing cancer cells to restore anticancer drug sensitivity in cases in which cancer has acquired resistance to an anticancer drug and inducing cell death in cancer cells. The present invention specifically provides a cancer cell death inducing agent comprising REIC/Dkk-3 DNA as an active ingredient and having effects of potentiating an anticancer drug for cancer cells having anticancer drug resistance.
    Type: Grant
    Filed: November 5, 2008
    Date of Patent: February 3, 2015
    Assignee: Momotaro-Gene Inc.
    Inventors: Hiromi Kumon, Yasutomo Nasu, Masami Watanabe, Yuji Kashiwakura, Kensuke Kawasaki
  • PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING CANCER BY INDUCING DENDRITIC CELL-LIKE DIFFERENTIATION FROM MONOCYTES TO IMPROVE ANTICANCER IMMUNE ACTIVITY
    Publication number: 20140056945
    Abstract: According to the present invention, a composition for inducing or activating dendritic cell-like cells so as to treat or prevent cancer by immunotherapy is provided. Specifically, the following is provided: an agent for activating cancer immunity, which comprises, as an active ingredient, the following REIC protein: (a) a protein consisting of the amino acid sequence shown in SEQ ID NO: 2; or (b) a protein consisting of an amino acid sequence derived from the amino acid sequence shown in SEQ ID NO: 2 by substitution, deletion, or addition of one or more amino acid(s) and having the activity of inducing differentiation from monocytes into dendritic cell-like cells.
    Type: Application
    Filed: November 5, 2013
    Publication date: February 27, 2014
    Applicant: Momotaro-Gene Inc.
    Inventors: Hiromi KUMON, Yasutomo Nasu, Masami Watanabe, Yuji Kashiwakura
  • Therapeutic agent for malignant mesothelioma and immunostimulant
    Patent number: 8658612
    Abstract: A method for potentiating the antitumor immunity in an animal by administering REIC/Dkk-3, or a therapeutic agent for malignant mesothelioma containing REIC/Dkk-3, or a vector containing the DNA as an active ingredient; wherein the DNA consists of the nucleotide sequence shown in SEQ ID NO: 1; or (b) a DNA hybridizing under stringent conditions to the DNA consisting of a nucleotide sequence complementary to the nucleotide sequence shown in SEQ ID NO: 1 and encoding a protein having apoptosis-inducing activity and interleukin (IL-7) production-accelerating activity in cells.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: February 25, 2014
    Assignees: National University Corporation Okayama University, Momotaro-Gene Inc.
    Inventors: Hiromi Kumon, Yasutomo Nasu, Yuji Kashiwakura, Masami Watanabe, Nam-ho Huh, Masakiyo Sakaguchi
  • Pharmaceutical composition for treating or preventing cancer by inducing dendritic cell-like differentiation from monocytes to improve anticancer immune activity
    Patent number: 8614093
    Abstract: According to the present invention, a composition for inducing or activating dendritic cell-like cells so as to treat or prevent cancer by immunotherapy is provided. Specifically, the following is provided: an agent for activating cancer immunity, which comprises, as an active ingredient, the following REIC protein: (a) a protein consisting of the amino acid sequence shown in SEQ ID NO: 2; or (b) a protein consisting of an amino acid sequence derived from the amino acid sequence shown in SEQ ID NO: 2 by substitution, deletion, or addition of one or more amino acid(s) and having the activity of inducing differentiation from monocytes into dendritic cell-like cells.
    Type: Grant
    Filed: March 24, 2009
    Date of Patent: December 24, 2013
    Assignee: Momotaro-Gene Inc.
    Inventors: Hiromi Kumon, Yasutomo Nasu, Masami Watanabe, Yuji Kashiwakura
  • PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING CANCER BY INDUCING DENDRITIC CELL-LIKE DIFFERENTIATION FROM MONOCYTES TO IMPROVE ANTICANCER IMMUNE ACTIVITY
    Publication number: 20120034251
    Abstract: According to the present invention, a composition for inducing or activating dendritic cell-like cells so as to treat or prevent cancer by immunotherapy is provided. Specifically, the following is provided: an agent for activating cancer immunity, which comprises, as an active ingredient, the following REIC protein: (a) a protein consisting of the amino acid sequence shown in SEQ ID NO: 2; or (b) a protein consisting of an amino acid sequence derived from the amino acid sequence shown in SEQ ID NO: 2 by substitution, deletion, or addition of one or more amino acid(s) and having the activity of inducing differentiation from monocytes into dendritic cell-like cells.
    Type: Application
    Filed: March 24, 2009
    Publication date: February 9, 2012
    Applicant: MOMOTARO-GENE INC.
    Inventors: Hiromi Kumon, Yasutomo Nasu, Masami Watanabe, Yuji Kashiwakura
  • CANCER CELL DEATH INDUCING AGENT HAVING EFFECTS OF POTENTIATING ANTICANCER DRUG AGAINST ANTICANCER-DRUG-RESISTANT CANCER
    Publication number: 20110269824
    Abstract: The present invention provides a drug capable of causing cancer cells to restore anticancer drug sensitivity in cases in which cancer has acquired resistance to an anticancer drug and inducing cell death in cancer cells. The present invention specifically provides a cancer cell death inducing agent comprising REIC/Dkk-3 DNA as an active ingredient and having effects of potentiating an anticancer drug for cancer cells having anticancer drug resistance.
    Type: Application
    Filed: November 5, 2008
    Publication date: November 3, 2011
    Applicant: Momotaro-Gene Inc.
    Inventors: Hiromi Kumon, Yasutomo Nasu, Masami Watanabe, Yuji Kashiwakura, Kensuke Kawasaki
  • Therapeutic Agent for Malignant Mesothelioma and Immunostimulant
    Publication number: 20110189237
    Abstract: According to the present invention, a method for treating malignant mesothelioma using REIC/Dkk-3 and a therapeutic agent for malignant mesothelioma comprising REIC/Dkk-3 are provided. A mesothelioma therapeutic agent is provided, comprising the following REIC/Dkk-3 DNA or a vector comprising the DNA as an active ingredient: (a) a DNA consisting of the nucleotide sequence shown in SEQ ID NO: 1; or (b) a DNA hybridizing under stringent conditions to a DNA consisting of a nucleotide sequence complementary to the nucleotide sequence shown in SEQ ID NO: 1 and encoding a protein having apoptosis-inducing activity and IL-7 production-accelerating activity in cells.
    Type: Application
    Filed: July 30, 2009
    Publication date: August 4, 2011
    Applicants: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY, Momotaro-Gene Inc.
    Inventors: Hiromi Kumon, Yasutomo Nasu, Yuji Kashiwakura, Masami Watanabe, Nam-ho Huh, Masakiyo Sakaguchi