Abstract: A wire harness includes a cable unit, and an indicator provided that is on a back surface portion of an outer circumference surface of the cable unit, the back surface portion being positioned on an opposite side to a front surface portion that is visually recognizable from a direction in which the wire harness is visually recognizable to a worker in a normal attachment state in which the cable unit is attached to a vehicle in a predefined attachment manner.

Abstract: In a section of a spark plug cut by a plane which passes through the center of gravity of the intermediate member and is in parallel with the facing direction between a center electrode and an extending portion of a ground electrode, a spark plug that satisfies the relational expression S1/(D1×H1)?0.005, where S1 is the total area of nuggets, H1 is the height of the end surface of a noble metal tip from the disposition surface of an electrode base metal, and D1 is the maximum width of the noble metal tip.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula (I) is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- or -L1-L2-LP- wherein the antibody is connected to the terminal of L1, the antitumor compound is connected to the terminal of Lc or LP, and any one or two or more of linkers of L1, L2, and LP has a hydrophilic structure.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lc with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: A spark plug includes a ceramic insulator, a center electrode, a metallic shell, and a ground electrode. The center electrode has a shoulder portion at a forward end portion, which tapers forward with respect to the axial direction. A noble metal tip is joined to the forward end portion of the center electrode through a fusion zone. A spark discharge gap is formed between the noble metal tip and the ground electrode. The shortest distance between the fusion zone and a forward end surface of the noble metal tip is 0.8-1.2 mm. The outside diameter of the fusion zone as measured at a forward end of the fusion zone is smaller than that as measured at a rear end of the fusion zone. An acute angle ?1 formed by a straight line L1 and a straight line L2 satisfies the relational expression ?1?72°.

Abstract: A buried portion (32B) buried from a junction target surface of a ground electrode (27) is provided in a noble metal tip (32). In a section, perpendicular to a central axis CL2 of the ground electrode (27), a large width portion (32W) is formed in the buried portion (32B), and a region between the junction target surface and a largest width region of the large width portion (32W) is formed into a shape which gradually increases in width, or into a shape having a region of the relevant shape and a constant width region. A region from the large width portion (32W) to a point of intersection P1, P2 is covered with a base material of the ground electrode (27) and a melt portion (35), and a thickness t1 (mm) of the noble metal tip (32) and a buried amount t2 (mm) satisfy 0.25?t2/t1.

Abstract: An object is to provide a technique for improving welding strength between an intermediate member and an electrode member. In a section of a spark plug cut by a plane which passes through the center of gravity of the intermediate member and is in parallel with the facing direction between a center electrode and an extending portion of a ground electrode, the spark plug satisfies the relational expression S1/(D1×H1)?0.005, where S1 is the total area of nuggets, H1 is the height of the end surface of a noble metal tip from the disposition surface of an electrode base metal, and D1 is the maximum width of the noble metal tip.

Abstract: A spark plug includes a ceramic insulator, a center electrode, a metallic shell, and a ground electrode. The center electrode has a shoulder portion at a forward end portion, which tapers forward with respect to the axial direction. A noble metal tip is joined to the forward end portion of the center electrode through a fusion zone. A spark discharge gap is formed between the noble metal tip and the ground electrode. The shortest distance between the fusion zone and a forward end surface of the noble metal tip is 0.8-1.2 mm. The outside diameter of the fusion zone as measured at a forward end of the fusion zone is smaller than that as measured at a rear end of the fusion zone. An acute angle ?1 formed by a straight line L1 and a straight line L2 satisfies the relational expression ?1?72°.

Abstract: A buried portion (32B) buried from a junction target surface of a ground electrode (27) is provided in a noble metal tip (32). In a section, perpendicular to a central axis CL2 of the ground electrode (27), a large width portion (32W) is formed in the buried portion (32B), and a region between the junction target surface and a largest width region of the large width portion (32W) is formed into a shape which gradually increases in width, or into a shape having a region of the relevant shape and a constant width region. A region from the large width portion (32W) to a point of intersection P1, P2 is covered with a base material of the ground electrode (27) and a melt portion (35), and a thickness t1 (mm) of the noble metal tip (32) and a buried amount t2 (mm) satisfy 0.25?t2/t1.

Abstract: The present invention relates to an immunoliposome preparation or a hydrophobic molecule-modified antibody having a therapeutic effect on cancer, autoimmune disease, or inflammatory disease. Specifically, the present invention relates to an immunoliposome or a hydrophobic molecule-modified antibody comprising, as a constituent, an antibody capable of inducing the apoptosis of cells expressing a death domain-containing receptor.

Abstract: A copolymer or a pharmacologically acceptable salt thereof is provided, which contains, as constitutional units, (a) one or more structural units of formula (I): wherein m is an integer of from 3 to 100, Alk represents alkyline, and R1 and R2 are the same or different and each represents hydrogen or optionally substituted alkyl, and (b) one or more structural units of formula (II): wherein R3 represents hydroxyl, optionally substituted alkoxy, optionally substituted aryloxy, or a group represented by the formula —NR4R5, wherein R4 and R5 are the same or different and each represents hydrogen or optionally substituted alkyl.

Abstract: A copolymer or a pharmacologically acceptable salt thereof is provided, which contains, as constitutional units, (a) one or more structural units of formula (I): wherein m is an integer of from 3 to 100, Alk represents alkyline, and R1 and R2 are the same or different and each represents hydrogen or optionally substituted alkyl, and (b) one or more structural units of formula (II): wherein R3 represents hydroxyl, optionally substituted alkoxy, optionally substituted aryloxy, or a group represented by the formula —NR4R5, wherein R4 and R5 are the same or different and each represents hydrogen or optionally substituted alkyl.