Abstract: A workpiece transport device is downsized. A workpiece transport device includes: a pair of upstream-side end shaft and downstream-side end shafts disposed apart from each other in a transport direction that is a direction of transport of a workpiece, an upstream-side drive shaft disposed between a pair of upstream-side end shaft and downstream-side end shafts in the transport direction, an upstream-side drive belt wound around the upstream-side drive shaft and the upstream-side end shaft, and a transport belt wound around the pair of upstream-side end shaft and downstream-side end shaft. Driving force for transporting the workpiece is transmitted to the transport belt through the upstream-side drive shaft, the upstream-side drive belt, and the upstream-side end shaft in this order.

Abstract: This tool conveying device is provided with an indexing device comprising an input shaft, a first output shaft, and a second output shaft which is positioned adjacent and parallel to the first output shaft, wherein the input shaft is linked to a servo motor, the first output shaft rotates during rotation of the input shaft and the second output shaft stops at a prescribed angular position in a certain period during rotation of the input shaft and rotates in the remaining period during said rotation of the input shaft; a gripper; a turning part which is driven by the second output shaft of the indexing device and which supports the gripper; and a gripper opening/closing member which is driven by the first output shaft of the indexing device.

Abstract: This machine tool is provided with an arm for exchanging a tool between a main shaft in a machining chamber and a secondary tool standby position in a tool holding chamber, a shutter which is provided in an opening defined in a wall which partitions between the machining chamber and the tool holding chamber, a first motor for opening and closing the shutter, a shutter position detector which can detect the position of the shutter in the entire range between the fully open position and the fully closed position, a storage device which stores a prescribed position of the shutter associated with a prescribed operation of the arm and a control device which is configured to perform a prescribed operation of the arm on the basis of the position of the shutter detected by the shutter position detector and the prescribed position of the shutter stored in the storage device.

Abstract: The present disclosure provides methods for preventing, alleviating, or treating cytokine release resulting from administration of a VEGF inhibitor or side effects resulting from the cytokine release. To prevent, alleviate, or treat cytokine release or its side effects, the disclosure also provides combination therapies that use a lymphocyte-stimulating pharmaceutical agent, represented by an anti-T cell antigen-binding molecule, with a VEGF inhibitor. Among the anti-T cell antigen-binding molecules, for example, antibodies that recruit T cells as effector cells into tumor tissues are called T cell redirecting antibodies, and are known as means for treating tumors. On the other hand, when systemic cytokine production is stimulated by binding of antibodies to T cells, it is feared that this systemic action will lead to aberrations such as CRS.

Abstract: The present disclosure provides antibodies capable of distinguishing between wild-type FGFR3 and FGFR3 S249C mutants. Using these antibodies, antigen-binding molecules capable of selectively damaging tumor cells expressing an FGFR3 S249C mutant were constructed.

Abstract: A laser processing device according an embodiment is a laser processing device that irradiates a processing region of a workpiece with pulsed laser light through a liquid to subject the processing region to a laser peening process or a laser forming process. The laser processing device includes: a laser irradiation unit including a laser oscillator that outputs the pulsed laser light; and an accommodation unit that includes an injection port through which the liquid is injected to the processing region, and accommodates the laser irradiation unit. A pulse width of the pulsed laser light is 200 ps to 2 ns, and the pulsed laser light output from the laser oscillator is emitted to the processing region through a liquid that is injected from the injection port.

Abstract: This machine tool is provided with an arm for exchanging a tool between a main shaft in a machining chamber and a secondary tool standby position in a tool holding chamber, a shutter which is provided in an opening defined in a wall which partitions between the machining chamber and the tool holding chamber, a first motor for opening and closing the shutter, a shutter position detector which can detect the position of the shutter in the entire range between the fully open position and the fully closed position, a storage device which stores a prescribed position of the shutter associated with a prescribed operation of the arm and a control device which is configured to perform a prescribed operation of the arm on the basis of the position of the shutter detected by the shutter position detector and the prescribed position of the shutter stored in the storage device.

Abstract: This tool conveying device is provided with an indexing device comprising an input shaft, a first output shaft, and a second output shaft which is positioned adjacent and parallel to the first output shaft, wherein the input shaft is linked to a servo motor, the first output shaft rotates during rotation of the input shaft and the second output shaft stops at a prescribed angular position in a certain period during rotation of the input shaft and rotates in the remaining period during said rotation of the input shaft; a gripper; a turning part which is driven by the second output shaft of the indexing device and which supports the gripper; and a gripper opening/closing member which is driven by the first output shaft of the indexing device.

Abstract: The present invention provides anticancer agents comprising as an active ingredient a bispecific antibody that comprises a domain comprising a glypican 3-binding antibody variable region, a domain comprising a T cell receptor complex-binding antibody variable region, and common L chains that can enhance the affinity for the two antigens, as well as pharmaceutical compositions comprising the bispecific antibody as an active ingredient, the compositions being for use in combination with other anticancer agents. The bispecific antibodies are novel molecules which are produced with high efficiency and have strong anti-tumor activity as well as safety and excellent pharmacodynamics. The bispecific antibodies can be expected to be applied to various cancers.

Abstract: A machining center is provided with: a base; a table that supports a workpiece; a main-shaft head that causes a tool to rotate around an axis of rotation of a main-shaft; a Z-axis drive device that causes the table to move with respect to the base along a Z axis parallel to the axis of rotation of the main-shaft; a W-axis drive device that causes the main-shaft head to move with respect to the base along a W axis parallel to the axis of rotation of the main-shaft; and a control device that controls the Z-axis drive device and the W-axis drive device so as to cause the tool to process the workpiece by causing the table and the main-shaft head to move along the Z axis and the W axis, respectively.

Abstract: The present invention provides anticancer agents comprising as an active ingredient a bispecific antibody that comprises a domain comprising a glypican 3-binding antibody variable region, a domain comprising a T cell receptor complex-binding antibody variable region, and common L chains that can enhance the affinity for the two antigens, as well as pharmaceutical compositions comprising the bispecific antibody as an active ingredient, the compositions being for use in combination with other anticancer agents. The bispecific antibodies are novel molecules which are produced with high efficiency and have strong anti-tumor activity as well as safety and excellent pharmacodynamics. The bispecific antibodies can be expected to be applied to various cancers.

Abstract: A metal additive manufacturing technique is provided to improve various characteristics by irradiation of a pulse laser without disposing a transparent medium. A metal additive manufacturing device includes: a material supply source configured to supply a material to be deposited; a heat source configured to melt the material by outputting an energy beam; a moving driver configured to scan at least the energy beam; and a laser irradiator configured to irradiate a solidified portion of the material in a temperature lowering process with a pulse laser.

Abstract: This machine tool has: a main shaft having a tool mounted on the tip thereof; a main shaft head that rotatably supports the main shaft; orthogonal triaxial linear feed shafts that move the main shaft and a table relative to one another; and a rotational feed shaft that is capable of changing the orientation of the rotational axis of the main shaft. The machine tool is provided with: a rotational feed shaft device that is not parallel to any of the linear feed shafts and that rotates the main shaft head around an inclined axis that intersects the rotational axis of the main shaft; and a main shaft head base that rotatably supports the main shaft head so that the point of intersection between the rotational axis and the inclined axis of the main shaft coincides with a defined reference point at the tip side of the main shaft.

Abstract: A semiconductor module includes a base plate for dissipating heat and a body having a bottom surface facing the base plate, a top surface opposite the bottom surface, and side surfaces between the bottom and top surfaces, wherein a first main electrode through which a first main current flows faces a first side surface among the side surfaces, and a second main electrode through which a second main current flows faces a second side surface opposite the first side surface. A power conversion apparatus includes a plurality of the semiconductor modules, wherein a cylindrical section is formed by arranging the semiconductor modules to surround a predetermined position, some of the first and second main electrodes are arranged on a first ring-shaped end surface at one end of the cylindrical section, and remaining electrodes are arranged on a second ring-shaped end surface at another end of the cylindrical section.

Abstract: The present invention provides anticancer agents comprising as an active ingredient a bispecific antibody that comprises a domain comprising a glypican 3-binding antibody variable region, a domain comprising a T cell receptor complex-binding antibody variable region, and common L chains that can enhance the affinity for the two antigens, as well as pharmaceutical compositions comprising the bispecific antibody as an active ingredient, the compositions being for use in combination with other anticancer agents. The bispecific antibodies are novel molecules which are produced with high efficiency and have strong anti-tumor activity as well as safety and excellent pharmacodynamics. The bispecific antibodies can be expected to be applied to various cancers.

Abstract: A semiconductor module includes a base plate for dissipating heat and a body having a bottom surface facing the base plate, a top surface opposite the bottom surface, and side surfaces between the bottom and top surfaces, wherein a first main electrode through which a first main current flows faces a first side surface among the side surfaces, and a second main electrode through which a second main current flows faces a second side surface opposite the first side surface. A power conversion apparatus includes a plurality of the semiconductor modules, wherein a cylindrical section is formed by arranging the semiconductor modules to surround a predetermined position, some of the first and second main electrodes are arranged on a first ring-shaped end surface at one end of the cylindrical section, and remaining electrodes are arranged on a second ring-shaped end surface at another end of the cylindrical section.

Abstract: As a result of producing anti-DDR1 antibodies and conducting extensive studies on the antitumor activity thereof, antibodies that bind to the stalk domain in the amino acid sequence of human DDR1 were found to have a potent activity even when used alone compared to antibodies that bind to other domains. It was also found that the antibodies have one or more activities selected from the group consisting of: (i) an activity to suppress cell proliferation, (ii) an activity to inhibit cell migration, (iii) an activity to inhibit phosphorylation of DDR1 in cells, (iv) an activity to be taken up into cells, (v) an activity to decrease the expression level of DDR1 in cells, and (vi) an activity to decrease the expression level of TGF-? in cells.

Abstract: A plasma display apparatus including a capacitive load and a driving circuit is provided. The plasma display apparatus includes a driving power source supplying a drive voltage to the capacitive load and a reference potential terminal supplying a reference potential to the capacitive load. A drive IC is coupled to the driving power source.

Abstract: A laser processing apparatus for radiating a laser beam to a member to be treated provided in an air environment to perform surface treatment. The member to be treated forms a structure extending in a vertical direction. The laser processing apparatus includes: a liquid supply mechanism that jets and supplies liquid to a surface of the member to be treated; a laser radiation mechanism that radiates the laser beam in pulses to the surface of the member to be treated via the liquid; and a cylindrical gas laminar flow nozzle disposed below the liquid supply mechanism and configured to jet a gas upward to form a gas flow surrounding the member to be treated around an axis direction thereof.

Abstract: A plasma display apparatus including a capacitive load and a driving circuit is provided. The plasma display apparatus includes a driving power source supplying a drive voltage to the capacitive load and a reference potential terminal supplying a reference potential to the capacitive load. A drive IC is coupled to the driving power source.