Patents by Inventor Yujing Yang
Yujing Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12238129Abstract: Methods and apparatuses for implementing customized anomaly detection. A time-series data including a plurality of data points is obtained. Anomaly detection is performed to the time-series data with an anomaly detection model. A feedback associated with an anomaly detection result of at least one data point in the time-series data is received. The anomaly detection model is updated based at least on the feedback through reinforcement learning.Type: GrantFiled: November 17, 2020Date of Patent: February 25, 2025Assignee: Microsoft Technology Licensing, LLCInventors: Congrui Huang, Yujing Wang, Bixiong Xu, Guodong Xing, Mao Yang, Jie Tong, Jing Bai, Meng Ai, Qi Zhang
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Publication number: 20240271194Abstract: Disclosed herein are methods for generating an ratiometric symbol for sequential hybridization barcoding for multiplexed Fluorescence In Situ Hybridization (FISH). Also, the disclosure sets forth methods, in addition to using the same, and other solutions to problems in the relevant field.Type: ApplicationFiled: June 8, 2022Publication date: August 15, 2024Inventors: Long CAI, Chee Huat (Linus) ENG, Yujing YANG
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Publication number: 20210395804Abstract: This disclosure herein sets forth embodiments to provide a serological test to detect target analytes that can scale to up to 10,000 or more samples in a single run. This disclosure herein sets forth methods to allow for unique barcoding by using a multi-level barcode scheme that is modular and enables easy detection of multiple analytes in samples.Type: ApplicationFiled: June 18, 2021Publication date: December 23, 2021Inventors: Long CAI, Chee Huat (Linus) ENG, James J. PARK, Yujing YANG, Michal POLONSKY
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Patent number: 7396465Abstract: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.Type: GrantFiled: May 1, 2007Date of Patent: July 8, 2008Assignee: Pall CorporationInventors: Xiaosong Wu, Chung-Jen Hou, Jayesh Dharia, Peter Konstantin, Yujing Yang
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Publication number: 20070207493Abstract: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.Type: ApplicationFiled: May 1, 2007Publication date: September 6, 2007Applicant: PALL CORPORATIONInventors: Xiaosong WU, Chung-Jen HOU, Jayesh DHARIA, Peter KONSTANTIN, Yujing YANG
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Patent number: 7223341Abstract: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.Type: GrantFiled: July 6, 2006Date of Patent: May 29, 2007Assignee: Pall CorporationInventors: Xiaosong Wu, Chung-Jen Hou, Jayesh Dharia, Peter Konstantin, Yujing Yang
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Patent number: 7189322Abstract: The present invention provides a hydrophilic charged microporous membrane comprising a porous hydrophobic substrate and a coating comprising a charge-providing agent. The present invention further provides a hydrophilic charged membrane comprising a porous hydrophobic substrate and a hydrophilic charge-providing agent distributed within the substrate. The present invention further provides a filter as well as a filter device comprising the inventive hydrophilic charged membrane. The present invention further provides a process for treating a fluid containing bacterial contaminants such as endotoxins comprising contacting the membrane with the fluid to provide a bacterial contaminant depleted fluid.Type: GrantFiled: January 26, 2005Date of Patent: March 13, 2007Assignee: Pall CorporationInventors: Xiaosong Wu, Joe L. Kinsey, Jr., Michael Ishee, Peter Konstantin, Joel Shertok, Yujing Yang
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Publication number: 20060249445Abstract: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.Type: ApplicationFiled: July 6, 2006Publication date: November 9, 2006Applicant: Pall CorporationInventors: Xiaosong Wu, Chung-Jen Hou, Jayesh Dharia, Peter Konstantin, Yujing Yang
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Patent number: 7132049Abstract: The present invention provides, in certain embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having fixed negative charges. The crosslinked coating can be prepared, e.g., from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- and/or N-(alkoxymethyl)-acrylamide, a hydrophilic unsaturated monomer, and an initiator. The present invention further provides, in some embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating prepared from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- or N-(alkoxymethyl)-acrylamide, a polysaccharide, and an initiator. The membranes of the present invention are suitable for use in ion exchange chromatography, for example, in the separation and purification of positively charged species such as proteins.Type: GrantFiled: January 19, 2005Date of Patent: November 7, 2006Assignee: Pall CorporationInventors: Chung-Jen Hou, Peter Konstantin, Yujing Yang
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Patent number: 7094347Abstract: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.Type: GrantFiled: January 18, 2005Date of Patent: August 22, 2006Assignee: Pall CorporationInventors: Xiaosong Wu, Chung-Jen Hou, Jayesh Dharia, Peter Konstantin, Yujing Yang
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Publication number: 20060151374Abstract: The present invention provides a hydrophilic charged microporous membrane comprising a porous hydrophobic substrate and a coating comprising a charge-providing agent. The present invention further provides a hydrophilic charged membrane comprising a porous hydrophobic substrate and a hydrophilic charge-providing agent distributed within the substrate. The present invention further provides a filter as well as a filter device comprising the inventive hydrophilic charged membrane. The present invention further provides a process for treating a fluid containing bacterial contaminants such as endotoxins comprising contacting the membrane with the fluid to provide a bacterial contaminant depleted fluid.Type: ApplicationFiled: January 26, 2005Publication date: July 13, 2006Applicant: Pall CorporationInventors: Xiaosong Wu, Joe Kinsey, Michael Ishee, Peter Konstantin, Joel Shertok, Yujing Yang
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Publication number: 20050211621Abstract: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.Type: ApplicationFiled: January 18, 2005Publication date: September 29, 2005Applicant: Pall CorporationInventors: Xiaosong Wu, Chung-Jen Hou, Jayesh Dharia, Peter Konstantin, Yujing Yang
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Publication number: 20050139537Abstract: The present invention provides, in certain embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having fixed negative charges. The crosslinked coating can be prepared, e.g., from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- and/or N-(alkoxymethyl)-acrylamide, a hydrophilic unsaturated monomer, and an initiator. The present invention further provides, in some embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating prepared from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- or N-(alkoxymethyl)-acrylamide, a polysaccharide, and an initiator. The membranes of the present invention are suitable for use in ion exchange chromatography, for example, in the separation and purification of positively charged species such as proteins.Type: ApplicationFiled: January 19, 2005Publication date: June 30, 2005Applicant: Pall CorporationInventors: Chung-Jen Hou, Peter Konstantin, Yujing Yang
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Patent number: 6860393Abstract: The present invention provides, in certain embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having fixed negative charges. The crosslinked coating can be prepared, e.g., from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- and/or N-(alkoxymethyl)-acrylamide, a hydrophilic unsaturated monomer, and an initiator. The present invention further provides, in some embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating prepared from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- or N-(alkoxymethyl)-acrylamide, a polysaccharide, and an initiator. The membranes of the present invention are suitable for use in ion exchange chromatography, for example, in the separation and purification of positively charged species such as proteins.Type: GrantFiled: July 21, 2004Date of Patent: March 1, 2005Assignee: Pall CorporationInventors: Chung-Jen Hou, Peter Konstantin, Yujing Yang
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Patent number: 6851561Abstract: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.Type: GrantFiled: July 15, 2004Date of Patent: February 8, 2005Assignee: Pall CorporationInventors: Xiaosong Wu, Chung-Jen Hou, Jayesh Dharia, Peter Konstantin, Yujing Yang
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Patent number: 6849185Abstract: The present invention provides a hydrophilic charged microporous membrane comprising a porous hydrophobic substrate and a coating comprising a charge-providing agent. The present invention further provides a hydrophilic charged membrane comprising a porous hydrophobic substrate and a hydrophilic charge-providing agent distributed within the substrate. The present invention further provides a filter as well as a filter device comprising the inventive hydrophilic charged membrane. The present invention further provides a process for treating a fluid containing bacterial contaminants such as endotoxins comprising contacting the membrane with the fluid to provide a bacterial contaminant depleted fluid.Type: GrantFiled: May 12, 2000Date of Patent: February 1, 2005Inventors: Xiaosong Wu, Joe L. Kinsey, Jr., Michael Ishee, Peter Konstantin, Joel Shertok, Yujing Yang
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Publication number: 20040262216Abstract: The present invention provides, in certain embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having fixed negative charges. The crosslinked coating can be prepared, e.g., from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- and/or N-(alkoxymethyl)-acrylamide, a hydrophilic unsaturated monomer, and an initiator. The present invention further provides, in some embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating prepared from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- or N-(alkoxymethyl)-acrylamide, a polysaccharide, and an initiator. The membranes of the present invention are suitable for use in ion exchange chromatography, for example, in the separation and purification of positively charged species such as proteins.Type: ApplicationFiled: July 21, 2004Publication date: December 30, 2004Applicant: Pall CorporationInventors: Chung-Jen Hou, Peter Konstantin, Yujing Yang
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Publication number: 20040251193Abstract: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.Type: ApplicationFiled: July 15, 2004Publication date: December 16, 2004Applicant: Pall CorporationInventors: Xiaosong Wu, Chung-Jen Hou, Jayesh Dharia, Peter Konstantin, Yujing Yang
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Patent number: 6783937Abstract: The present invention provides, in certain embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having fixed negative charges. The crosslinked coating can be prepared, e.g., from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- and/or N-(alkoxymethyl)-acrylamide, a hydrophilic unsaturated monomer, and an initiator. The present invention further provides, in some embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating prepared from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- or N-(alkoxymethyl)-acrylamide, a polysaccharide, and an initiator. The membranes of the present invention are suitable for use in ion exchange chromatography, for example, in the separation and purification of positively charged species such as proteins.Type: GrantFiled: December 12, 2001Date of Patent: August 31, 2004Assignee: Pall CorporationInventors: Chung-Jen Hou, Peter Konstantin, Yujing Yang
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Patent number: 6780327Abstract: The present invention provides a positively charged microporous membrane having a protein binding capacity about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.Type: GrantFiled: December 12, 2001Date of Patent: August 24, 2004Assignee: Pall CorporationInventors: Xiaosong Wu, Chung-Jen Hou, Jayesh Dharia, Peter Konstantin, Yujing Yang