Abstract: Provided are methods for expanding stem cells and/or lineage committed progenitor cells, such as hematopoietic stems cells and/or lineage committed progenitor cells, at least in part, by using compounds that antagonize AhR. The compounds are represented by formulae: wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification. Also provided are compositions comprising stem cells and/or lineage committed progenitor cells expanded by methods disclosed herein and methods for the treatment of diseases treatable by same.

Abstract: The present invention provides methods of negatively modulating the Werner protein (WRN) to inhibit proliferative cells characterized by high microsatellite instability (MSI-H), for example to treat proliferative diseases (such as cancer) characterized by high MSI (MSI-H). Further provided are compositions used in such methods.

Abstract: Provided are methods for expanding stem cells and/or lineage committed progenitor cells, at least in part, by using lactam compounds that antagonize AhR. The compounds are represented by formula (I): wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided below. Also provided are compositions comprising stem cells and/or lineage committed progenitor cells expanded by methods disclosed herein and methods for the treatment of diseases treatable by same.

Abstract: A storage apparatus includes a plurality of drives having different response speeds, a memory that stores location information of data stored in the plurality of drives, and a processor operable to execute performing rearrangement of the data among the plurality of drives in accordance with a specific condition, updating the location information of the data whose rearrangement has been performed, and starting copying from data that is used for startup of a host connected to another storage apparatus among a plurality of pieces of data to be copied to the other storage apparatus in accordance with the location information stored in the memory, the other storage device being redundantly configured with the storage apparatus.

Abstract: The present invention provides methods of using improved macrolide compositions in the treatment of cystic fibrosis. The macrolide compounds of Formulas 1-21 described herein may be used alone or in a cotherapeutic regimen with other agents that are active against cystic fibrosis. The present invention also provides compositions and methods for treating inflammatory conditions.

Abstract: An earthquake-proof leg support structure (10) of an electronic apparatus comprising a leg (12) vertically downwardly extending from the outer case (1) and a dish-shaped leg support seat (20) to receive the leg (12). The leg support seat (20) includes a metal element (28) having an upper surface (22) over which the leg (12) slides and a peripheral flange (24) against which the leg (12) abuts, and a plastic liner (30) having a lower flat smooth surface (26) which is slidable on the floor. The lower end surface (14) of the leg is of a convex spherical shape and the upper surface (22) of the leg support seat includes a central surface portion (22a) of a concave spherical shape and a cone-shaped slope portion (22b) arranged around and tangential to the central surface portion, with the radius of curvature of the leg (12) being smaller than that of the upper surface (22) of the leg support seat (20 ).

Abstract: A tape draw-out mechanism comprises a tape draw-out member to be engaged with a tape between a pair of reels and tape draw-out member driving means for reciprocating the tape draw-out member between an initial position and a tape drawn-out position and driving the tape draw-out member so that the return time required for returning the tape draw-out member to the initial position from the tape drawn-out position is shorter than the time required for moving the tape draw-out member to the tape drawn-out position from the initial position. Drawing-out and return of the tape are performed by the reciprocating movement of the tape draw-out member.