Abstract: The present application relates to the field of pharmaceutical preparations and relates to [1,2,4]triazolo [1,5-a]pyridine compounds and their isomers or pharmaceutically acceptable salts or their crystal forms, as well as local topical preparations and their applications in skin diseases. Specifically, it relates to a local topical formulations of compound (S)—N-(5-(2-(2,2-difluorocyclopropanecarbonyl)-2-nitrospiro[3.5]non-7-yl)-[1,2,4-triazole[1,5-a]pyridine-2-yl) cyclopropaneformamide and its isomers or pharmaceutically acceptable salts or crystal forms, and their applications in skin diseases. The preferred skin diseases include psoriasis, atopic dermatitis, vitiligo, lupus erythematosus, alopecia areata, eczema, contact dermatitis, urticaria, pompholyxs, dermatomyositis, scleroderma, acne, and seborrheic dermatitis.

Abstract: An oral preparation, specifically including a JAK inhibitor and pharmaceutical excipients is provided, wherein the JAK inhibitor includes a compound of formula (I), an isomer thereof, pharmaceutically acceptable salts thereof, or their crystal form. The oral preparation of the present application has the characteristic of rapid dissolution. The oral preparation process of the present application is simple and suitable for large-scale industrial production.

Abstract: The invention provides a method for hand-over of a terminal from a first base station to a second base station, radio network element, terminal, base station and a communication system. The method for hand-over of a terminal from a first base station to a second base station, wherein said first base station is EV-DO enabled in an access network and said second base station is not EV-DO enabled, said method comprising: transmitting an EV-DO pilot signal from said second base station to said terminal; sending a route update message including an EV-DO pilot strength from said terminal if said EV-DO pilot strength is above a predetermined threshold; calculating a CDMA pilot strength based on said EV-DO pilot strength; and performing the hand-over of said terminal to said second base station when CDMA pilot strength is above the hand-over threshold.

Abstract: The invention provides a method for hand-over of a terminal from a first base station to a second base station, radio network element, terminal, base station and a communication system. The method for hand-over of a terminal from a first base station to a second base station, wherein said first base station is EV-DO enabled in an access network and said second base station is not EV-DO enabled, said method comprising: transmitting an EV-DO pilot signal from said second base station to said terminal; sending a route update message including an EV-DO pilot strength from said terminal if said EV-DO pilot strength is above a predetermined threshold; calculating a CDMA pilot strength based on said EV-DO pilot strength; and performing the hand-over of said terminal to said second base station when CDMA pilot strength is above the hand-over threshold.