Patents by Inventor Yujun Zhou
Yujun Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12119580Abstract: The present disclosure relates to an external device-to-external device connector for wireless communication devices, which is configured to electrically connect two spaced external devices together, and comprises two interface members and a coupling member. The inner conductor part and the insulation part of the coupling member are held together by the concave-convex fitting parts opposite to each other, and there is a first gap between the concave-convex fitting part of the inner conductor part and that of the insulation part, which allows the inner conductor part to have radial displacement relative to the insulation part; or, the outer conductor part and the insulating part of the coupling member are held together by the concave-convex fitting parts opposite to each other, and there is a second gap between the concave-convex fitting part of the outer conductor part and that of the insulating part, which allows radial displacement of the insulating part relative to the outer conductor part.Type: GrantFiled: April 14, 2022Date of Patent: October 15, 2024Assignee: Outdoor Wireless Networks LLCInventors: Mulan Huang, Yujun Zhang, Yuanyao Zhou
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Patent number: 11635426Abstract: A test strip and kit for testing mycophenolic acid and a preparation method of the test strip are described. The test strip includes a bottom plate and a sample pad, a glassfiber membrane, a nitrocellulose membrane and an absorbent paper which are successively lapped on a surface of the bottom plate, the sample pad is treated by a sample pad treatment fluid; the glassfiber membrane is treated by a glassfiber membrane treatment fluid; the glassfiber membrane is coated by a mycophenolic acid specific-antibody conjugate; the nitrocellulose membrane is provided with a detection line and a quality control line; and a mycophenolic acid protein conjugate is sprayed on the detection line.Type: GrantFiled: August 30, 2019Date of Patent: April 25, 2023Assignee: BEIJING DIAGREAT BIOTECHNOLOGIES CO., LTD.Inventors: Jianping Zhou, Yujun Zhou, Xiuli Xu
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Publication number: 20220383987Abstract: Provided are a method and device for creating a gene mutation dictionary, and a method and device for compressing genomic data using the gene mutation dictionary. The method for creating a gene mutation dictionary includes: obtaining genome sequence data of a plurality of individuals of a species and reference genome data of the species; aligning genome sequence data of each individual to the reference genome data to obtain a mutation result of the genome sequence data of each individual relative to the reference genome data; partitioning a genome of the species into a plurality of unit regions of biological significance; and generating a plurality of mutant patterns of the individuals in each unit region by statistically analyzing mutant status for each unit region based on the mutation result, and numbering the mutant patterns, to obtain the gene mutation dictionary.Type: ApplicationFiled: June 29, 2022Publication date: December 1, 2022Inventors: Chongjun XU, Yujun ZHOU, Ziqing DENG, Meihua GONG, Hui JIANG, Xun XU
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Publication number: 20210355459Abstract: Provided are a Phi29 DNA polymerase mutant with improved thermal stability and an use thereof in sequencing. The phi29 DNA polymerase mutant is represented by A) or B) below: the DNA polymerase mutant represented by the A) is a protein having DNA polymerase activity that is obtained by modifying at least one amino acid residue(s) in the following six sites in a phi29 DNA polymerase amino acid sequence: the 97-th, 123-th, 217-th, 224-th, 515-th, and 474-th sites; the DNA polymerase mutant represented by the B) is a protein having DNA polymerase activity that is derived from the A) by adding a tag sequence to a terminal of the amino acid sequence of the protein represented by the A).Type: ApplicationFiled: October 11, 2018Publication date: November 18, 2021Inventors: Zhougang ZHANG, Huanhuan LIU, Yue ZHENG, Yujun ZHOU, Jun XIA, Yuliang DONG, Chongjun XU, Wenwei ZHANG
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Patent number: 11141732Abstract: A detection kit for quickly detecting a lead content lead a sample is provided, and belongs to the technical field of medical in vitro immunoassay. The kit includes a detection card and a quality control; the detection card includes a bottom plate, and a sample pad, a glass fiber membrane, a nitrocellulose membrane and an absorbent paper which are arranged on the surface of the bottom plate sequentially from a loading end. The provided kit has advantages of having simple preprocessing, having no need of digestion, and being economic, fast and convenient, and the like, can realize storage at room temperature, a rapid speed, a high throughout, a low instrument cost, simple and convenient operations, single-person packaging, and detection at any time, which greatly improves the simplicity and convenience of clinical use.Type: GrantFiled: December 23, 2019Date of Patent: October 12, 2021Assignee: Beijing Diagreat Biotechnologies Co., Ltd.Inventors: Jianping Zhou, Yanxin Wang, Yujun Zhou
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Patent number: 11104889Abstract: Provided are a group of phi29 DNA polymerase mutants having increased thermal stability and use thereof. The phi29 DNA polymerase mutants are proteins obtained by performing point mutation A and/or point mutation B and/or point mutation C on phi29 DNA polymerase, the point mutation A meaning that an amino acid residue M at position 97 of the phi29 DNA polymerase is mutated to other amino acid residue, the point mutation B meaning that an amino acid residue L at position 123 of the phi29 DNA polymerase is mutated into other amino acid residue, and the point mutation C meaning that an amino acid residue E at position 515 of the phi29 DNA polymerase is mutated to other amino acid residue. The stability of the phi29 DNA polymerase mutants is higher than that of a wild-type phi29 DNA polymerase.Type: GrantFiled: August 9, 2017Date of Patent: August 31, 2021Assignee: MGI TECH CO., LTD.Inventors: Zhougang Zhang, Huanhuan Liu, Yue Zheng, Yujun Zhou, Xing Liu, Yuliang Dong, Chongjun Xu, Wenwei Zhang
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Publication number: 20210094030Abstract: A detection kit for quickly detecting a lead content lead a sample is provided, and belongs to the technical field of medical in vitro immunoassay. The kit includes a detection card and a quality control; the detection card includes a bottom plate, and a sample pad, a glass fiber membrane, a nitrocellulose membrane and an absorbent paper which are arranged on the surface of the bottom plate sequentially from a loading end. The provided kit has advantages of having simple preprocessing, having no need of digestion, and being economic, fast and convenient, and the like, can realize storage at room temperature, a rapid speed, a high throughout, a low instrument cost, simple and convenient operations, single-person packaging, and detection at any time, which greatly improves the simplicity and convenience of clinical use.Type: ApplicationFiled: December 23, 2019Publication date: April 1, 2021Applicant: Beijing Diagreat Biotechnologies Co., Ltd.Inventors: Jianping Zhou, Yanxin Wang, Yujun Zhou
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Publication number: 20210096075Abstract: The present invention relates to a detection kit for quickly detecting a cadmium content in a sample, and belongs to the technical field of medical in vitro immunoassay. The kit of the present invention includes a detection card and a quality control; the detection card includes a bottom plate, and a sample pad, a glass fiber membrane, a nitrocellulose membrane and an absorbent paper which are arranged on the surface of the bottom plate sequentially from a loading end. The kit of the present invention has advantages of a low detection instrument cost, simple and rapid operations, storage and transportation at room temperature, realization of packaging for a single person, and a good stability.Type: ApplicationFiled: December 30, 2019Publication date: April 1, 2021Inventors: Jianping Zhou, Yanxin Wang, Yujun Zhou
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Patent number: 10961519Abstract: Provided are a phi29 DNA polymerase mutant with increased thermo stability, a method for preparing the mutant, the use of the mutant, and a method for increasing the stability of the phi29 DNA polymerase.Type: GrantFiled: October 18, 2019Date of Patent: March 30, 2021Assignee: MGI TECH CO., LTD.Inventors: Huanhuan Liu, Yue Zheng, Yujun Zhou, Xi Zhang, Zhougang Zhang, Yuliang Dong, Wenwei Zhang, Chongjun Xu, Snezana Drmanac
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Publication number: 20210055288Abstract: The invention provides immunochromatographic test strips for detecting digoxin and uses thereof. The immunochromatographic test strips include a bottom plate, a sample pad, a glass fiber mat, a nitrocellulose membrane and a water absorbing paper that are sequentially overlapped on the bottom plate. The glass fiber mat is sprayed with a digoxin-specific antibody-fluorescent microsphere complex. The nitrocellulose membrane is sequentially provided with a detection line coated with digoxin protein conjugate and a quality control line coated with a secondary antibody. The digoxin-specific antibody-fluorescent microsphere complex is obtained by conjugation between a digoxin monoclonal antibody or a digoxin polyclonal antibody and a fluorescent microsphere. The digoxin protein conjugate includes a digoxin-conjugated rabbit albumin or a digoxin-conjugated rabbit ovalbumin. The test strips provided by the invention are low cost, provide simple and rapid use, and have excellent stability and high sensitivity.Type: ApplicationFiled: October 10, 2019Publication date: February 25, 2021Applicant: Beijing Diagreat Biotechnologies Co., Ltd.Inventors: Jianping ZHOU, Yujun ZHOU, Xiuli XU
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Publication number: 20210025880Abstract: A test strip and kit for testing mycophenolic acid and a preparation method of the test strip are described. The test strip includes a bottom plate and a sample pad, a glassfiber membrane, a nitrocellulose membrane and an absorbent paper which are successively lapped on a surface of the bottom plate, the sample pad is treated by a sample pad treatment fluid; the glassfiber membrane is treated by a glassfiber membrane treatment fluid; the glassfiber membrane is coated by a mycophenolic acid specific-antibody conjugate; the nitrocellulose membrane is provided with a detection line and a quality control line; and a mycophenolic acid protein conjugate is sprayed on the detection line.Type: ApplicationFiled: August 30, 2019Publication date: January 28, 2021Applicant: BEIJING DIAGREAT BIOTECHNOLOGIES CO., LTD.Inventors: Jianping ZHOU, Yujun ZHOU, Xiuli XU
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Publication number: 20200208126Abstract: Provided are a group of phi29 DNA polymerase mutants having increased thermal stability and use thereof. The phi29 DNA polymerase mutants are proteins obtained by performing point mutation A and/or point mutation B and/or point mutation C on phi29 DNA polymerase, the point mutation A meaning that an amino acid residue M at position 97 of the phi29 DNA polymerase is mutated to other amino acid residue, the point mutation B meaning that an amino acid residue L at position 123 of the phi29 DNA polymerase is mutated into other amino acid residue, and the point mutation C meaning that an amino acid residue E at position 515 of the phi29 DNA polymerase is mutated to other amino acid residue. The stability of the phi29 DNA polymerase mutants is higher than that of a wild-type phi29 DNA polymerase.Type: ApplicationFiled: August 9, 2017Publication date: July 2, 2020Inventors: Zhougang Zhang, Huanhuan Liu, Yue Zheng, Yujun Zhou, Xing Liu, Yuliang Dong, Chongjun Xu, Wenwei Zhang
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Publication number: 20200115686Abstract: Provided are a phi29 DNA polymerase mutant with increased thermo stability, a method for preparing the mutant, the use of the mutant, and a method for increasing the stability of the phi29 DNA polymerase.Type: ApplicationFiled: October 18, 2019Publication date: April 16, 2020Inventors: Huanhuan Liu, Yue Zheng, Yujun Zhou, Xi Zhang, Zhougang Zhang, Yuliang Dong, Wenwei Zhang, Chongjun Xu, Snezana Drmanac