Patents by Inventor YUK KEE CHEUNG POH

YUK KEE CHEUNG POH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems, methods, and devices for in vivo delivery using remote actuation of implantable hydrogel MEMS devices
    Patent number: 10420885
    Abstract: MicroElectroMechanical System (MEMS) devices can be fabricated completely of hydrogel materials. Such hydrogels can include polyethylene glycol with diacrylate functional groups (e.g., PEGDA), which are photopolymerizable in the presence of crosslinkers and photoinitiators. By using PEGDA monomers of different molecular weights and at different percentages, the mechanical properties of the polymerized gels and their respective permeabilities can be tuned. This spatial variation in properties and permeabilities can lead to different functionalities between different portions of the hydrogel MEMS device. Portions of the hydrogel device may be remotely actuated by applying wave energy, for example, a magnetic field, high intensity focused ultrasound, and/or infrared radiation. The remote actuation can allow the device to be actuated in vivo, for example, to allow the device to deliver a drug or other substance at a desired time and/or desired location within a patient.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: September 24, 2019
    Assignee: The Trustees of Columbia in the City of New York
    Inventors: Samuel K. Sia, Sau Yin Chin, Anne-Celine Kohler, Yuk Kee Cheung Poh
  • Systems, Methods, and Devices for In Vivo Delivery Using Remote Actuation of Implantable Hydrogel MEMS Devices
    Publication number: 20180256816
    Abstract: MicroElectroMechanical System (MEMS) devices can be fabricated completely of hydrogel materials. Such hydrogels can include polyethylene glycol with diacrylate functional groups (e.g., PEGDA), which are photopolymerizable in the presence of crosslinkers and photoinitiators. By using PEGDA monomers of different molecular weights and at different percentages, the mechanical properties of the polymerized gels and their respective permeabilities can be tuned. This spatial variation in properties and permeabilities can lead to different functionalities between different portions of the hydrogel MEMS device. Portions of the hydrogel device may be remotely actuated by applying wave energy, for example, a magnetic field, high intensity focused ultrasound, and/or infrared radiation. The remote actuation can allow the device to be actuated in vivo, for example, to allow the device to deliver a drug or other substance at a desired time and/or desired location within a patient.
    Type: Application
    Filed: January 16, 2018
    Publication date: September 13, 2018
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Samuel K. SIA, Sau Yin CHIN, Anne-Celine KOHLER, Yuk Kee Cheung POH
  • Systems, methods, and devices for in vivo delivery using remote actuation of implantable hydrogel MEMS devices
    Patent number: 9907906
    Abstract: MicroElectroMechanical System (MEMS) devices can be fabricated completely of hydrogel materials. Such hydrogels can include polyethylene glycol with diacrylate functional groups (e.g., PEGDA), which are photopolymerizable in the presence of crosslinkers and photoinitiators. By using PEGDA monomers of different molecular weights and at different percentages, the mechanical properties of the polymerized gels and their respective permeabilities can be tuned. This spatial variation in properties and permeabilities can lead to different functionalities between different portions of the hydrogel MEMS device. Portions of the hydrogel device may be remotely actuated by applying wave energy, for example, a magnetic field, high intensity focused ultrasound, and/or infrared radiation. The remote actuation can allow the device to be actuated in vivo, for example, to allow the device to deliver a drug or other substance at a desired time and/or desired location within a patient.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: March 6, 2018
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Olga Ordeig, Samuel K. Sia, Sau Yin Chin, Anne-Celine Kohler, Yuk Kee Cheung Poh
  • Field optimized assay devices, methods, and systems
    Patent number: 9268911
    Abstract: A portable unitary device handheld diagnostic device can be operated with minimal power requirement and provides ease of operation as well as low cost communication of diagnostic data from remote locations. The device can provide nucleic-acid based diagnostics with minimal training, little to no sample preparation, and generates diagnostic data in about 45 minutes. A system can enable point of care transmission from any location globally using a low cost satellite-based data link technique, for example, Short Burst Data (SBD), combined with data encoding.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: February 23, 2016
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Samuel K. Sia, Mario Matteo Modena, Paolo Cadinu, Keith Yeager, Yuk Kee Cheung Poh, Robert Houghtaling, Tassaneewan Laksanasopin, Curtis D. Chin
  • FIELD OPTIMIZED ASSAY DEVICES, METHODS, AND SYSTEMS
    Publication number: 20140333453
    Abstract: A portable unitary device handheld diagnostic device can be operated with minimal power requirement and provides ease of operation as well as low cost communication of diagnostic data from remote locations. The device can provide nucleic-acid based diagnostics with minimal training, little to no sample preparation, and generates diagnostic data in about 45 minutes. A system can enable point of care transmission from any location globally using a low cost satellite-based data link technique, for example, Short Burst Data (SBD), combined with data encoding.
    Type: Application
    Filed: July 23, 2014
    Publication date: November 13, 2014
    Inventors: Samuel K. SIA, Mario Matteo MODENA, Paolo CADINU, Keith YEAGER, Yuk Kee Cheung POH, Robert HOUGHTALING, Tassaneewan LAKSANASOPIN, Curtis D. CHIN
  • SYSTEMS, METHODS, AND DEVICES FOR IN VIVO DELIVERY USING REMOTE ACTUATION OF IMPLANTABLE HYDROGEL MEMS DEVICES
    Publication number: 20140031750
    Abstract: MicroElectroMechanical System (MEMS) devices can be fabricated completely of hydrogel materials. Such hydrogels can include polyethylene glycol with diacrylate functional groups (e.g., PEGDA), which are photopolymerizable in the presence of crosslinkers and photoinitiators. By using PEGDA monomers of different molecular weights and at different percentages, the mechanical properties of the polymerized gels and their respective permeabilities can be tuned. This spatial variation in properties and permeabilities can lead to different functionalities between different portions of the hydrogel MEMS device. Portions of the hydrogel device may be remotely actuated by applying wave energy, for example, a magnetic field, high intensity focused ultrasound, and/or infrared radiation. The remote actuation can allow the device to be actuated in vivo, for example, to allow the device to deliver a drug or other substance at a desired time and/or desired location within a patient.
    Type: Application
    Filed: July 29, 2013
    Publication date: January 30, 2014
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: OLGA ORDEIG, SAMUEL K. SIA, SAU YIN CHIN, ANNE-CELINE KOHLER, YUK KEE CHEUNG POH