Patents by Inventor Yuk Lo

Yuk Lo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20070275402
    Abstract: This application provides the use of novel fetal markers for prenatal diagnosis and monitoring of certain pregnancy-related conditions. More specifically, the invention resides in the discovery that certain CpG islands located on fetal chromosome 21 demonstrate a methylation profile that is distinct from that of the corresponding CpG islands located on maternal chromosome 21. This application also provides kits for diagnosing or monitoring of the relevant conditions.
    Type: Application
    Filed: April 6, 2007
    Publication date: November 29, 2007
    Applicant: The Chinese University of Hong Kong
    Inventors: Yuk Lo, Rossa Chiu, Stephen Chim, Chunming Ding, Shengnan Jin, Tracy Lee, Fiona Lun
  • Publication number: 20070207466
    Abstract: The present invention is directed to methods of detecting nucleic acids in a biological sample. The method is based on a novel combination of a base extension reaction, which provides excellent analytical specificity, and a mass spectrometric analysis, which provides excellent specificity. The method can be used, for example, for diagnostic, prognostic and treatment purposes. The method allows accurate detection of nucleic acids that are present in very small amounts in a biological sample. For example, the method of the present invention is preferably used to detect fetal nucleic acid in a maternal blood sample; circulating tumor-specific nucleic acids in a blood, urine or stool sample; and donor-specific nucleic acids in transplant recipients. In another embodiment, one can detect viral, bacterial, fungal, or other foreign nucleic acids in a biological sample.
    Type: Application
    Filed: February 28, 2006
    Publication date: September 6, 2007
    Applicants: The Trustees of Boston University, The Chinese University of Hong Kong
    Inventors: Charles Cantor, Chunming Ding, Yuk Lo, Rossa Chiu