Patents by Inventor Yuka FUJITO
Yuka FUJITO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240077463Abstract: Provided is a method capable of shortening the time required for analysis and capable of analyzing various substances produced by microorganisms. A method for analyzing a metabolite of a microorganism according to the present invention includes: a step of supplying a mobile phase including carbon dioxide in a liquid state, a subcritical state, or a supercritical state to a container in which a microorganism cultured in a medium is contained together with the medium, to move a component of a metabolite of the microorganism present in the microorganism and the medium to the mobile phase; a step of introducing a mobile phase to which a component of the metabolite has moved into a column; and a step of performing mass spectrometry on a component of the metabolite contained in the mobile phase that has passed through the column.Type: ApplicationFiled: January 17, 2022Publication date: March 7, 2024Applicants: SHIMADZU CORPORATION, NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY, AJINOMOTO CO., INC.Inventors: Shinnosuke HORIE, Yuka FUJITO, Tomohisa HASUNUMA, Takanobu YOSHIDA, Erika URAHATA
-
Publication number: 20230274925Abstract: An analysis method includes: performing liquid chromatography using a mobile phase including an adsorption prevention agent for preventing adsorption of a sample including a compound having a phosphate group to metal; and performing mass spectrometry on an eluate of the liquid chromatography. The adsorption prevention agent includes an oxalic acid or a salt of the oxalic acid.Type: ApplicationFiled: May 5, 2023Publication date: August 31, 2023Inventors: Yuka FUJITO, Takanari HATTORI, Tomohisa HASUNUMA
-
Patent number: 11731106Abstract: A column packing material for supercritical fluid chromatography which allows good peak shape to be obtained in the analysis of free fatty acids, etc. and in the analysis of agricultural chemicals, etc., and has excellent durability for repeated analysis. The column packing material for supercritical fluid chromatography includes polymer particles containing cross-linked polymer, the degree of swelling of which after absorbing tetrahydrofuran and the degree of swelling of which after absorbing methanol are both 1.4 or less.Type: GrantFiled: October 2, 2019Date of Patent: August 22, 2023Assignee: SHIMADZU CORPORATIONInventors: Risa Ishii, Michio Butsugan, Keita Sakurai, Yuka Fujito
-
Patent number: 11694886Abstract: An analysis method includes: performing liquid chromatography using a mobile phase including an adsorption prevention agent for preventing adsorption of a sample including a compound having a phosphate group to metal; and performing mass spectrometry on an eluate of the liquid chromatography. The adsorption prevention agent includes an oxalic acid or a salt of the oxalic acid.Type: GrantFiled: October 30, 2019Date of Patent: July 4, 2023Assignees: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY, SHIMADZU CORPORATIONInventors: Yuka Fujito, Takanari Hattori, Tomohisa Hasunuma
-
Publication number: 20230184643Abstract: A method for identifying a target component of interest in a specimen by probe electrospray ionization mass spectrometry, including: (1) adsorbing the target component of interest onto an extraction phase for adsorbing the target component of interest from the specimen by immersing a probe into the specimen, wherein the probe is at least partially coated with the extraction phase; (2) removing the probe from the specimen and optionally quick rising it by dipping in or spraying water or acetone/water mixtures; (3) adhering solvent to the extraction phase; (4) desorbing the target component of interest into the solvent from the extraction phase; (5) electrospraying the target component of interest desorbed in the solvent adhered to the probe on the ionization source at atmospheric pressure by applying a voltage to the probe to spray aerosolized ionized droplets out of the probe; and (6) identifying the target component of interest present in the aerosolized ionized droplets.Type: ApplicationFiled: April 3, 2021Publication date: June 15, 2023Applicants: SHIMADZU CORPORATION, JP SCIENTIFIC LIMITEDInventors: Janusz B. PAWLISZYN, Milaan THIRUKUMARAN, Varoon SINGH, Yohei ARAO, Yuka FUJITO, Masayuki NISHIMURA, Tairo OGURA
-
Publication number: 20230184726Abstract: As a technique for separating odorous compounds by using a supercritical fluid chromatograph, a method for separating an odorous compound is provided which includes a process of carrying a sample containing an odorous compound into a column filled with a packing material made of a polymer having an unsaturated hydrocarbon structure, by a flow of a mobile phase which is a supercritical fluid of a predetermined substance.Type: ApplicationFiled: December 9, 2021Publication date: June 15, 2023Applicant: SHIMADZU CORPORATIONInventors: Yuka FUJITO, Takeshi BAMBA
-
Publication number: 20230128516Abstract: A controller (50) of a liquid chromatograph (1) is configured to execute, as an analysis operation in an analysis unit (3), a sample injection step of bringing a high-pressure valve (10) into a loading state, sucking a sample from a tip of a needle (12) to hold a sample in a sampling channel (2), then connecting the sampling channel (2) to an injection port (16) and bringing the high-pressure valve (10) into an injecting state, and supplying a mobile phase from a liquid supplier (6), thereby injecting a sample held in the sampling channel (12) into an analysis channel (4), and an analysis step of separating components of a sample injected into the analysis channel (4) in a separation column (14) by bringing the high-pressure valve (10) in the loading state and supplying the mobile phase from the liquid supplier (6) after the sample injection step is ended.Type: ApplicationFiled: October 8, 2022Publication date: April 27, 2023Inventors: Yuka FUJITO, Logan MILLER
-
Publication number: 20230088216Abstract: A liquid chromatograph includes at least one mobile phase supply flow path (6; 42), at least one cleaning solution supply flow path (8; 44) joining the mobile phase supply flow path (6; 42), an analysis flow path (4) provided with a separation column (14), a sampling flow path (2) provided, at a tip end thereof, with a sampling needle (12), a switcher (10; 26) including a high-pressure valve (10) having an injection port (16) and configured to switch a flow path configuration of the liquid chromatograph between a loading state in which the analysis mobile phase supply flow path (6) and the analysis flow path (4) are connected in a fluid manner without the sampling flow path (2) and an injecting state in which the sampling flow path (2) is interposed between the analysis mobile phase supply flow path (6) and the analysis flow path (4) when a tip end of the needle (12) is inserted into the injection port (16), and a controller (50) configured to execute, when a predetermined condition is satisfied, the cleaningType: ApplicationFiled: September 12, 2022Publication date: March 23, 2023Inventors: Yuka FUJITO, Logan MILLER
-
Patent number: 11519887Abstract: An analysis assistance method includes setting pressure in a first BPR to a value higher than a prescribed second set value with pressure in a second BPR set to a second set value, instructing a supercritical fluid chromatograph to supply a mobile phase to a supply flow path at a flow rate of the mobile phase that is to be theoretically supplied to a first flow path when the mobile phase is supplied to the supply flow path at a prescribed total flow rate and a prescribed sample introduction ratio, and gradually decreasing a set value of the pressure in the first BPR, and detecting a set value of the pressure in the first BPR at the time when supply of the mobile phase to a second flow path is stopped due to a decrease in set value of the pressure in the first BPR, as a first set value.Type: GrantFiled: September 16, 2019Date of Patent: December 6, 2022Assignee: SHIMADZU CORPORATIONInventor: Yuka Fujito
-
Patent number: 11243193Abstract: A supercritical fluid device includes an analytical channel, a liquid delivery part for delivering a mobile phase constituting a supercritical fluid in the analytical channel, a back pressure regulator for controlling a pressure of the analytical channel so as to cause the mobile phase in the analytical channel to reach a supercritical state, a sample injecting device that includes a sample holder for holding a sample and a switching valve for switching between a state where the sample holder is arranged on the analytical channel and a state where the sample holder is not arranged on the analytical channel, a bypass channel whose one end is connected to a position upstream of the sample injecting device and whose other end is connected to a position downstream of the sample injecting device on the analytical channel, and an analytical column for separating a sample introduced by the sample injecting device into individual components, the analytical column is provided downstream of the position to which the otType: GrantFiled: March 17, 2017Date of Patent: February 8, 2022Assignee: SHIMADZU CORPORATIONInventors: Yuka Fujito, Tairo Ogura, Kenichiro Tanaka
-
Publication number: 20220026403Abstract: A supercritical fluid chromatograph includes a liquid sender that supplies a mobile phase including a supercritical fluid to a supply flow path, first and second back pressure regulators that are respectively provided in first and second flow paths into which a path from the liquid sender branches and an analysis column provided at a position farther upstream than the first back pressure regulator in the first flow path.Type: ApplicationFiled: July 20, 2021Publication date: January 27, 2022Applicants: SHIMADZU CORPORATION, MIYAZAKI PREFECTURE, KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATIONInventors: Yuka FUJITO, Miho SAKAI, Takeshi BAMBA
-
Publication number: 20220013346Abstract: An analysis method includes: performing liquid chromatography using a mobile phase including an adsorption prevention agent for preventing adsorption of a sample including a compound having a phosphate group to metal; and performing mass spectrometry on an eluate of the liquid chromatography. The adsorption prevention agent includes an oxalic acid or a salt of the oxalic acid.Type: ApplicationFiled: October 30, 2019Publication date: January 13, 2022Inventors: Yuka FUJITO, Takanari HATTORI, Tomohisa HASUNUMA
-
Publication number: 20210116425Abstract: A sample is stored in a container (125) disposed upstream of a back-pressure control valve (140). A mixed fluid of carbon dioxide in a supercritical state and a modifier is introduced into the container, and a component contained in the sample is extracted. The extracted component is introduced into a trap column (135) together with the carbon dioxide and the modifier and collected in the trap column. The trap column is loaded with polymer beads as a filler.Type: ApplicationFiled: April 4, 2019Publication date: April 22, 2021Applicant: Shimadzu CorporationInventors: Yuka FUJITO, Risa ISHII, Michio BUTSUGAN, Keita SAKURAI
-
Publication number: 20210101131Abstract: A column packing material for supercritical fluid chromatography which allows good peak shape to be obtained in the analysis of free fatty acids, etc. and in the analysis of agricultural chemicals, etc., and has excellent durability for repeated analysis. The column packing material for supercritical fluid chromatography includes polymer particles containing cross-linked polymer, the degree of swelling of which after absorbing tetrahydrofuran and the degree of swelling of which after absorbing methanol are both 1.4 or less.Type: ApplicationFiled: October 2, 2019Publication date: April 8, 2021Applicant: SHIMADZU CORPORATIONInventors: Risa ISHII, Michio BUTSUGAN, Keita SAKURAI, Yuka FUJITO
-
Patent number: 10727037Abstract: A mass spectrometer for performing a selected ion monitoring (SIM) measurement and/or multiple reaction monitoring (MRM) measurement on each of one or a plurality of target components contained in a sample under one or a plurality of measurement conditions is provided. The mass spectrometer includes: a storage section 41 in which SIM measurement conditions and/or MRM measurement conditions are previously stored for a plurality of components; a measurement condition selection receiver 43 for performing the following operations when a command to create a method file in which measurement conditions are described is issued by a user: reading the selected ion monitoring measurement conditions and/or multiple reaction monitoring measurement conditions of the plurality of components, displaying the measurement conditions on a screen, and receiving a selection by the user; and a method file creator 48 for creating a method file in which a measurement condition selected by the user is described.Type: GrantFiled: February 22, 2018Date of Patent: July 28, 2020Assignee: SHIMADZU CORPORATIONInventor: Yuka Fujito
-
Publication number: 20200166485Abstract: An analysis assistance method includes setting pressure in a first BPR to a value higher than a prescribed second set value with pressure in a second BPR set to a second set value, instructing a supercritical fluid chromatograph to supply a mobile phase to a supply flow path at a flow rate of the mobile phase that is to be theoretically supplied to a first flow path when the mobile phase is supplied to the supply flow path at a prescribed total flow rate and a prescribed sample introduction ratio, and then instructing the supercritical fluid chromatograph to gradually decrease a set value of the pressure in the first BPR, and detecting a set value of the pressure in the first BPR at the time when supply of the mobile phase to a second flow path is stopped due to a decrease in set value of the pressure in the first BPR, as a first set value.Type: ApplicationFiled: September 16, 2019Publication date: May 28, 2020Applicant: SHIMADZU CORPORATIONInventor: Yuka FUJITO
-
Patent number: 10564135Abstract: A chromatograph mass spectrometer for performing SIM measurement and/or MRM measurement on a plurality of target components includes: a memory 41 for previously storing measurement conditions created for each of the target components, the measurement conditions including an SIM measurement ion or an MRM transition, a measurement execution time period, and an initial dwell time; a measurement time divider 42 for dividing an entire measurement time into a plurality of partial time periods having different combinations of measurements executed in the same time period; a time period input receiver 43 for receiving an input for selecting one of the partial time periods; a sensitivity information input receiver 45 for receiving an input of sensitivity information relating to the measurement conditions executed in the selected partial time period; a dwell time calculator 47 for calculating a changed dwell time by increasing or reducing the initial dwell time according to details of the input of the sensitivity inforType: GrantFiled: April 8, 2016Date of Patent: February 18, 2020Assignee: SHIMADZU CORPORATIONInventor: Yuka Fujito
-
Publication number: 20200025725Abstract: A supercritical fluid device includes an analytical channel, a liquid delivery part for delivering a mobile phase constituting a supercritical fluid in the analytical channel, a back pressure regulator for controlling a pressure of the analytical channel so as to cause the mobile phase in the analytical channel to reach a supercritical state, a sample injecting device that includes a sample holder for holding a sample and a switching valve for switching between a state where the sample holder is arranged on the analytical channel and a state where the sample holder is not arranged on the analytical channel, a bypass channel whose one end is connected to a position upstream of the sample injecting device and whose other end is connected to a position downstream of the sample injecting device on the analytical channel, and an analytical column for separating a sample introduced by the sample injecting device into individual components, the analytical column is provided downstream of the position to which the otType: ApplicationFiled: March 17, 2017Publication date: January 23, 2020Applicant: SHIMADZU CORPORATIONInventors: Yuka FUJITO, Tairo OGURA, Kenichiro TANAKA
-
Publication number: 20190154642Abstract: A chromatograph mass spectrometer for performing SIM measurement and/or MRM measurement on a plurality of target components includes: a memory 41 for previously storing measurement conditions created for each of the target components, the measurement conditions including an SIM measurement ion or an MRM transition, a measurement execution time period, and an initial dwell time; a measurement time divider 42 for dividing an entire measurement time into a plurality of partial time periods having different combinations of measurements executed in the same time period; a time period input receiver 43 for receiving an input for selecting one of the partial time periods; a sensitivity information input receiver 45 for receiving an input of sensitivity information relating to the measurement conditions executed in the selected partial time period; a dwell time calculator 47 for calculating a changed dwell time by increasing or reducing the initial dwell time according to details of the input of the sensitivity inforType: ApplicationFiled: April 8, 2016Publication date: May 23, 2019Applicant: SHIMADZU CORPORATIONInventor: Yuka FUJITO
-
Publication number: 20180313795Abstract: A sample, carbon dioxide in a supercritical state, and a modifier are introduced into a separation column disposed on the upstream side of a back pressure control valve, and components included in the sample are separated. The separation column is packed with polymer beads as a packing material. The sample thus separated may be further supplied to an analysis by chromatography and/or a mass analysis.Type: ApplicationFiled: April 27, 2018Publication date: November 1, 2018Applicant: Shimadzu CorporationInventors: Yuka FUJITO, Risa ISHII, Michio BUTSUGAN, Keita SAKURAI