Patents by Inventor Yuka MIZUE

Yuka MIZUE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR PRODUCING MESENCHYMAL STEM CELLS, THERAPEUTIC EFFECT MARKER OF MESENCHYMAL STEM CELLS, METHOD FOR DETERMINING THERAPEUTIC EFFECTS OF MESENCHYMAL STEM CELLS, AND CELLULAR PREPARATION CONTAINING MESENCHYMAL STEM CELLS
    Publication number: 20220348864
    Abstract: [Problem] To provide a cell preparation including mesenchymal stem cells (MSCs) having a high therapeutic effect. [Solution] A method for producing activated mesenchymal stem cells, including a step of culturing MSCs in a medium containing an activator that includes an extract from a mammalian fetal appendage as an active ingredient, using a cell culture carrier having a three-dimensional structure formed of a fiber is provided. A marker for a therapeutic effect of MSCs selected from the group consisting of p16ink4a, p14ARF, CDK4, CDK6, RB, and CD47, a method for determining a therapeutic effect using the marker, a method for determining suitability of MSCs to be treated with a treatment for enhancing a therapeutic effect of MSCs, a cell preparation including MSCs, and a method for producing the same are also provided.
    Type: Application
    Filed: June 9, 2022
    Publication date: November 3, 2022
    Applicant: Sapporo Medical University
    Inventors: Takako Chikenji, Mineko Fujimiya, Yuki Saito, Masako Nakano, Miho Otani, Yuka Mizue, Takashi Matsumura, Kozue Kamiya
  • METHOD FOR PRODUCING MESENCHYMAL STEM CELLS, THERAPEUTIC EFFECT MARKER OF MESENCHYMAL STEM CELLS, METHOD FOR DETERMINING THERAPEUTIC EFFECTS OF MESENCHYMAL STEM CELLS, AND CELLULAR PREPARATION CONTAINING MESENCHYMAL STEM CELLS
    Publication number: 20200131470
    Abstract: [Problem] To provide a cell preparation including mesenchymal stem cells (MSCs) having a high therapeutic effect. [Solution] A method for producing activated mesenchymal stem cells, including a step of culturing MSCs in a medium containing an activator that includes an extract from a mammalian fetal appendage as an active ingredient, using a cell culture carrier having a three-dimensional structure formed of a fiber is provided. A marker for a therapeutic effect of MSCs selected from the group consisting of p16ink4a, p14ARF, CDK4, CDK6, RB, and CD47, a method for determining a therapeutic effect using the maker, a method for determining suitability of MSCs to be treated with a treatment for enhancing a therapeutic effect of MSCs, a cell preparation including MSCs, and a method for producing the same are also provided.
    Type: Application
    Filed: April 25, 2018
    Publication date: April 30, 2020
    Applicant: Sapporo Medical University
    Inventors: Takako CHIKENJI, Mineko FUJIMIYA, Yuki SAITO, Masako NAKANO, Miho OTANI, Yuka MIZUE, Takashi MATSUMURA, Kozue KAMIYA
  • Activator for mesenchymal stem cells, activated mesenchymal stem cells, and method for producing same
    Patent number: 10512660
    Abstract: [Problem] To activate an abnormal mesenchymal stem cell whose therapeutic effect is lost or reduced, or rather which has a disease-exacerbating effect so as to be in a state suitable for cell transplant therapy. [Solution] An activator for mesenchymal stem cells, mesenchymal stem cells activated by the activator, a method for producing the same, and a pharmaceutical containing the activated mesenchymal stem cells are provided.
    Type: Grant
    Filed: March 11, 2015
    Date of Patent: December 24, 2019
    Assignee: Sapporo Medical University
    Inventors: Mineko Fujimiya, Kanna Nagaishi, Yuka Mizue, Takako Chikenji
  • ACTIVATOR FOR MESENCHYMAL STEM CELLS, ACTIVATED MESENCHYMAL STEM CELLS, AND METHOD FOR PRODUCING SAME
    Publication number: 20170071984
    Abstract: [Problem] To activate an abnormal mesenchymal stem cell whose therapeutic effect is lost or reduced, or rather which has a disease-exacerbating effect so as to be in a state suitable for cell transplant therapy. [Solution] An activator for mesenchymal stem cells, mesenchymal stem cells activated by the activator, a method for producing the same, and a pharmaceutical containing the activated mesenchymal stem cells are provided.
    Type: Application
    Filed: March 11, 2015
    Publication date: March 16, 2017
    Applicant: Sapporo Medical University
    Inventors: Mineko FUJIMIYA, Kanna NAGAISHI, Yuka MIZUE, Takako CHIKENJI