Abstract: Aqueous pharmaceutical compositions containing a fusion protein of an antibody and a lysosomal enzyme as an active ingredient, which are stable enough to be marketed, are disclosed. The aqueous pharmaceutical composition, for example, comprises the fusion protein of the antibody and the lysosomal enzyme at a concentration of 0.5 to 20 mg/mL, sodium chloride at a concentration of 0.3 to 1.2 mg/mL, sucrose at a concentration of 50 to 100 mg/mL, a nonionic surfactant at a concentration of 0.15 to 3 mg/mL, a buffer at a concentration of 3 to 30 mM, and is adjusted to pH 5.0 to 7.5.

Abstract: Novel systems and methods are provided that rapidly separate particles from a liquid. In an embodiment, a small volume of liquid (such as a blood sample, or any other solution with a concentration of particles) is input into a flow device implemented as a unilateral channel. When activated by an acoustic energy source (such as an ultrasound pulse), gas-liquid interfaces naturally occurring between the liquid in the flow device and a plurality of gas-filled cavities that line the channel will oscillate and create stable cavitation streaming within a localized region of the surrounding liquid. These oscillations create micro-vortices that gently remove and trap particles and debris from the liquid and adjacent surfaces. Fluid and particle manipulation can thus be accomplished on a passive, disposable chip that is placed on top of an external acoustic transducer with a coupling medium.

Abstract: Novel systems and methods are provided that rapidly separate particles from a liquid. In an embodiment, a small volume of liquid (such as a blood sample, or any other solution with a concentration of particles) is input into a flow device implemented as a unilateral channel. When activated by an acoustic energy source (such as an ultrasound pulse), gas-liquid interfaces naturally occurring between the liquid in the flow device and a plurality of gas-filled cavities that line the channel will oscillate and create stable cavitation streaming within a localized region of the surrounding liquid. These oscillations create micro-vortices that gently remove and trap particles and debris from the liquid and adjacent surfaces. Fluid and particle manipulation can thus be accomplished on a passive, disposable chip that is placed on top of an external acoustic transducer with a coupling medium.