Abstract: The invention provides an epidermal basement membrane structure formation accelerating preparation and a skin external preparation comprising a serine protease inhibitor, and optionally an accelerator of production of extracellular matrix protein components of the epidermal basement membrane. It also provides, as a means for producing artificial skin having an adequately formed basement membrane, an artificial skin-forming medium which comprises a serine protease inhibitor, and optionally an accelerator of production of extracellular matrix protein components of the epidermal basement membrane and a matrix metalloprotease inhibitor, as well as a method for producing the same.

Abstract: The invention provides an epidermal basement membrane structure formation accelerating preparation and a skin external preparation comprising a serine protease inhibitor, and optionally an accelerator of production of extracellular matrix protein components of the epidermal basement membrane. It also provides, as a means for producing artificial skin having an adequately formed basement membrane, an artificial skin-forming medium which comprises a serine protease inhibitor, and optionally an accelerator of production of extracellular matrix protein components of the epidermal basement membrane and a matrix metalloprotease inhibitor, as well as a method for producing the same.

Abstract: The invention provides an epidermal basement membrane structure formation accelerating preparation and a skin external preparation comprising a serine protease inhibitor, and optionally an accelerator of production of extracellular matrix protein components of the epidermal basement membrane. It also provides, as a means for producing artificial skin having an adequately formed basement membrane, an artificial skin-forming medium which comprises a serine protease inhibitor, and optionally an accelerator of production of extracellular matrix protein components of the epidermal basement membrane and a matrix metalloprotease inhibitor, as well as a method for producing the same.

Abstract: A multi-layer lightweight texture composition containing, (i) an oil component; (ii) water; (iii) a polyol; (iv) a nonionic surfactant selected from stearic acid polyoxyethylene (degree of polymerization n=3-10) cetyl ether, stearic acid polyoxyethylene (n=4-12) stearyl ether, stearic acid polyoxyethylene (n=3-15) lauryl ether, isostearic acid polyoxyethylene (n=2-10) lauryl ether, monostearic acid glycerol, lauroylglutamic acid polyoxyethylene (n=2-5) octyldodecyl ether diester, lauroylglutamic acid dipolyoxyethylene (n=2-5) stearyl ether, polyoxyethylene (n=3-50) oleyl ether, polyoxyethylene (n=2-12) diisostearate, and sorbitan monooleate; and (v) a water-soluble salt.