Abstract: The object of the present invention is to provide a method for increasing an amount of Protein A to be immobilized on the self-assembled monolayer. Immobilizing Protein A to the self-assembled monolayer through the structure represented following formula (II) obviates the object.

Abstract: Provided are a method for increasing an amount of glucose oxidase to be immobilized on the self-assembled monolayer and a sensor which comprises glucose oxidase immobilized with the method. The method of the disclosed technology is characterized by that one molecule of an amino acid is interposed between the self-assembled monolayer and the molecule of the glucose oxidase.

Abstract: Provided are a method for increasing an amount of streptavidin to be immobilized on the self-assembled monolayer and a sensor which comprises streptavidin immobilized with the method. The method of the current technology is characterized by that one molecule of an amino acid is interposed between the self-assembled monolayer and the molecule of streptavidin.

Abstract: The object of the present invention is to provide a method for increasing an amount of Protein A to be immobilized on the self-assembled monolayer. Immobilizing Protein A to the self-assembled monolayer through the structure represented following formula (II) obviates the object.

Abstract: The object of the present invention is to provide a method for increasing an amount of Protein A to be immobilized on the self-assembled monolayer. Immobilizing Protein A to the self-assembled monolayer through the structure represented following formula (II) obviates the object.

Abstract: The method of the present disclosure is characterized by that one molecule of the amino acid is interposed between the self-assembled monolayer and the molecule of the albumin. For example, a method is provided for immobilizing albumin on a self-assembled monolayer, the method including the following steps (a) and (b) in this order: a step (a) of preparing a substrate including one molecule of an amino acid and the self-assembled monolayer and a step (b) of supplying the albumin to the substrate to form a peptide bond represented by a predetermined chemical formula as a result of reaction between the carboxyl group of the one molecule of the amino acid and the amino group of the albumin.

Abstract: The method of the present disclosure is characterized by that one molecule of the amino acid is interposed between the self-assembled monolayer and the molecule of the antibody. For example, a method for immobilizing an antibody on a self-assembled monolayer is provided and the method including the following steps (a) and (b) in this order: a step (a) of preparing a substrate comprising one molecule of an amino acid and the self-assembled monolayer and a step (b) of supplying the antibody to the substrate to form a peptide bond represented by a predetermined chemical formula as a result of reaction between the carboxyl group of the one molecule of the amino acid and the amino group of the antibody.

Abstract: The object of the present invention is to provide a method for increasing an amount of Protein A to be immobilized on the self-assembled monolayer. Immobilizing Protein A to the self-assembled monolayer through the structure represented following formula (II) obviates the object.

Abstract: The present invention provides an immunological assay suitable to be carried out on a chip. After an antigen-antibody complex in which an antigen 2 to be measured and an antibody 3 have bound to each other was obtained in a reaction chamber 7, the amount of the antigen-antibody complex or the antibody that has not bound to the antigen to be measured by using a measurement solution obtained by using the sample solution 8 as a solvent. According to the present invention, the measurement solution for detecting the signal that reflects the amount of the substance to be measured can be obtained without using a buffer solution free from a substance to be measured, such as protein. Thus, it is not necessary to supply a buffer solution from the outside of the chip or to allow the buffer solution to be retained on the chip beforehand. Accordingly, an immunological assay can be carried out easily on a chip.

Abstract: The present invention provides an immunological assay suitable to be carried out on a chip. After an antigen-antibody complex in which an antigen to be measured and an antibody have bound to each other was obtained in a reaction chamber, the reaction chamber is washed using a sample solution and thereby the antigen-antibody complex and the antibody that has not bound to the antigen to be measured are separated from each other. According to the present invention, the reaction chamber can be washed to an extent that allows a signal reflecting the amount of the antigen to be measured to be detected with accuracy comparable to the case of using a wash solution without using a wash solution that is typified by Tris-HCl buffer that does not contain any antigens to be measured such as protein. Thus, it is not necessary to supply a wash solution from the outside of the chip or to allow a wash solution to be retained on the chip beforehand. Accordingly, an immunological assay can be carried out easily on a chip.

Abstract: A fluid chip has a liquid support 25 for supporting a liquid 24, a fluid passage 22 formed by being surrounded by the liquid support 25 and through which the liquid 24 moves, and a plurality of magnetic particles 21 disposed in the fluid passage 24. The magnetic particles 21 are aggregated by a permanent magnet 23 so as to block the fluid passage 22 and thus cut off flow of the liquid 24. The magnetic particles 21 are dispersed along a part of a wall of the fluid passage 22 so as to open the fluid passage 22 and thus allow the liquid 24 to flow.

Abstract: A liquid delivery apparatus 1 has a rotary substrate 2. The substrate 2 formed with a fluid passage 8A for communicating a supply chamber 6A and target chamber 7A. An inlet end portion 13 at which the fluid passage 8A is connected to the chamber 6A extends in a clockwise direction R1 of rotational directions of the substrate 2. The inlet end portion 13 holds a liquid 9 in the chamber 6A by a capillary force. The rotation drive unit 4 rotates the substrate 2 so that an inertial force exceeding the capillary force and directed to the clockwise direction R1 acts on the liquid 9 in the inlet end portion 13. Delivery behavior control of microfluid with a high degree of flexibility can be achieved.

Abstract: The present invention provides an immunological assay suitable to be carried out on a chip. After an antigen-antibody complex in which an antigen 2 to be measured and an antibody 3 have bound to each other was obtained in a reaction chamber 7, the amount of the antigen-antibody complex or the antibody that has not bound to the antigen to be measured by using a measurement solution obtained by using the sample solution 8 as a solvent. According to the present invention, the measurement solution for detecting the signal that reflects the amount of the substance to be measured can be obtained without using a buffer solution free from a substance to be measured, such as protein. Thus, it is not necessary to supply a buffer solution from the outside of the chip or to allow the buffer solution to be retained on the chip beforehand. Accordingly, an immunological assay can be carried out easily on a chip.

Abstract: The present invention provides an immunological assay suitable to be carried out on a chip. After an antigen-antibody complex in which an antigen to be measured and an antibody have bound to each other was obtained in a reaction chamber, the reaction chamber is washed using a sample solution and thereby the antigen-antibody complex and the antibody that has not bound to the antigen to be measured are separated from each other. According to the present invention, the reaction chamber can be washed to an extent that allows a signal reflecting the amount of the antigen to be measured to be detected with accuracy comparable to the case of using a wash solution without using a wash solution that is typified by Tris-HCl buffer that does not contain any antigens to be measured such as protein. Thus, it is not necessary to supply a wash solution from the outside of the chip or to allow a wash solution to be retained on the chip beforehand. Accordingly, an immunological assay can be carried out easily on a chip.

Abstract: The present invention provides a blood processing apparatus that can introduce a metered quantity of a blood sample into a chamber and does not require an opening linked to the chamber to be closed after the introduction of the blood sample. An introducing chamber, an injection port, and an air port are formed in a rotatable platform of a blood processing apparatus. The injection port links the introducing chamber with the outside of the rotatable platform. A blood sample is introduced from the injection port into the introducing chamber. A blood coagulant is held on the port wall surface of the air port and/or around a portion of the surface of the rotatable platform where the air port is open.

Abstract: A liquid delivery apparatus 1 has a rotary substrate 2. The substrate 2 formed with a fluid passage 8A for communicating a supply chamber 6A and target chamber 7A. An inlet end portion 13 at which the fluid passage 8A is connected to the chamber 6A extends in a clockwise direction R1 of rotational directions of the substrate 2. The inlet end portion 13 holds a liquid 9 in the chamber 6A by a capillary force. The rotation drive unit 4 rotates the substrate 2 so that an inertial force exceeding the capillary force and directed to the clockwise direction R1 acts on the liquid 9 in the inlet end portion 13. Delivery behavior control of microfluid with a high degree of flexibility can be achieved.

Abstract: A fluid chip has a liquid support 25 for supporting a liquid 24, a fluid passage 22 formed by being surrounded by the liquid support 25 and through which the liquid 24 moves, and a plurality of magnetic particles 21 disposed in the fluid passage 24. The magnetic particles 21 are aggregated by a permanent magnet 23 so as to block the fluid passage 22 and thus cut off flow of the liquid 24. The magnetic particles 21 are dispersed along a part of a wall of the fluid passage 22 so as to open the fluid passage 22 and thus allow the liquid 24 to flow.

Abstract: The present invention provides a blood processing apparatus that can introduce a metered quantity of a blood sample into a chamber and does not require an opening linked to the chamber to be closed after the introduction of the blood sample. An introducing chamber, an injection port, and an air port are formed in a rotatable platform of a blood processing apparatus. The injection port links the introducing chamber with the outside of the rotatable platform. A blood sample is introduced from the injection port into the introducing chamber. A blood coagulant is held on the port wall surface of the air port and/or around a portion of the surface of the rotatable platform where the air port is open.