Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lc with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: A light detection and ranging (LIDAR) system incorporates a scanning system with random access pointing. The scanning system has a light source that generates a coherent light, a micro-electro-mechanical system (MEMS) phased-array that steers the coherent light in a vertical direction, and a resonant scanner that scans the coherent light in a horizontal direction. The coherent light is projected onto a far field scene. The MEMS phased-array steers the coherent light to point the projected light on selected spots on the far field scene in random access fashion.

Abstract: The spatial phase modulation element is a so-called grating light valve for modulating the phase of light by displacing the ribbons. If the measurement light beam Lm (measurement light) is incident on such a spatial phase modulation element, the measurement light beam Lm is emitted in a direction corresponding to the displacement mode of the ribbons. That is, an emission direction of the measurement light beam Lm can be changed, and the measurement light beam Lm can be scanned across the object J by controlling the displacement mode of the ribbons. At this time, the measurement light beam Lm phase-modulated by the spatial phase modulation element is projected to the object J after being shaped into a linear beam. That is, the linear measurement light beam Lm is scanned across the object J.

Abstract: An optical scanner including micro-electromechanical system phased-arrays suitable for use in a LiDAR system, and methods of operating the same are described. Generally, the scanner includes an optical transmitter having first phased-arrays to receive light from a light source, form a swath of illumination in a far field scene and to modulate phases of the light to sweep or steer the swath over the scene in two-dimensions (2D). An optical receiver in the scanner includes second phased-arrays to receive light from the far field scene and direct at least some of the light onto a detector. The second phased-arrays are configured to de-scan the received light by directing light reflected from the far field scene onto the detector while rejecting background light. In one embodiment the second phased-arrays direct light from a slice of the far field scene onto a 1D detector array.

Abstract: Laser light from a light source part is guided to an irradiation plane by an irradiation optical system. In the irradiation optical system, element lenses are arrayed, and light fluxes that have passed through the element lenses respectively enter transparent elements. Irradiation regions of the light from the element lenses are superimposed on the irradiation plane. When each pair of adjacent target element lenses out of three target element lenses arrayed sequentially is regarded as a target element lens pair, the optical path lengths of three transparent elements corresponding to the three target element lenses are determined such that a peak position of light intensity on the irradiation plane resulting from the interference between the light fluxes through one target element lens pair is different from that corresponding to the other pair. This suppresses variations in light intensity caused by interference between the light fluxes on the irradiation plane.

Abstract: Laser light from a light source part is guided to an irradiation plane by an irradiation optical system. In the irradiation optical system, element lenses are arrayed, and light fluxes that have passed through the element lenses respectively enter transparent elements. Irradiation regions of the light from the element lenses are superimposed on the irradiation plane. When each pair of adjacent target element lenses out of three target element lenses arrayed sequentially is regarded as a target element lens pair, the optical path lengths of three transparent elements corresponding to the three target element lenses are determined such that a peak position of light intensity on the irradiation plane resulting from the interference between the light fluxes through one target element lens pair is different from that corresponding to the other pair. This suppresses variations in light intensity caused by interference between the light fluxes on the irradiation plane.