Abstract: The invention provides an orally disintegrating tablet that has both adequate tablet hardness and rapid disintegrability in the oral cavity, and that undergoes minor hardness reduction and maintains good oral disintegrability even when preserved under moist conditions. In particular, the invention relates to an orally disintegrating tablet containing (a) crystalline cellulose, (b) a calcium hydrogen phosphate compound, (c) a natural starch and (d) a lubricant, wherein the blending ratio to 100 wt % of the disintegrating tablet is (a) 9 to 60 wt %, (b) 16 to 60 wt %, (c) 3 to 40 wt % and (d) 0.01 to 1.8 wt %.

Abstract: The present invention provides a granular preparation that resists caking during preservation, namely, a granular preparation characteristically with suppressed caking, which comprises an active ingredient other than biguanide, a sugar or a sugar alcohol, an organic acid and a particular water-soluble polysaccharide; and a method of suppressing caking of a granular preparation, which includes adding a particular water-soluble polysaccharide to the active ingredient, sugar or sugar alcohol and organic acid.

Abstract: A pharmaceutical composition for transdermal administration comprising perospirone of the formula (1): or a pharmaceutically acceptable acid addition salt thereof, which can inhibit the generation of metabolites and continuously maintain the blood level of perospirone.

Abstract: A process for preparing crosslinked polyvinyl alcohol contact lenses through hydrolysis of a copolymer of a vinyl ester with triallyl isocyanurate, which includes preparing a mixture of 100 parts by weight of the vinyl ester with 0.05 to 5 parts by weight of the triallyl isocyanurate, filling a mold composed of a male mold and a female mold with the mixture, applying ultraviolet ray to form a lens-shaped polymer, and hydrolyzing the resultant polymer. Since this process has a lens-shaped polymer formed without machinery processings, the lens surface is not roughened and the shape stability of the completed lens in a swollen state is so good that the handleability thereof is good and the lens can be mass-prepared with equalized quality.