Patents by Inventor Yuki Iwaki

Yuki Iwaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Liquid fuel injector
    Patent number: 11873761
    Abstract: A liquid fuel injector includes a cylindrical primary fuel injecting body having a central axis; an annular shroud concentrically placed radially outside; and an annular secondary fuel injecting body placed concentrically with the primary fuel injecting body and the shroud between the primary fuel injecting body and the shroud. A plurality of inner swirlers placed at equal intervals in a circumferential direction are provided in an annular inner air passage formed between the primary fuel injecting body and the secondary fuel injecting body, and a plurality of outer swirlers placed at equal intervals in the circumferential direction are provided in an annular outer air passage formed between the secondary fuel injecting body and the shroud. The primary fuel injecting body is formed as a pressure spray-type injector, and the secondary fuel injecting body and the inner and outer air passages cooperatively constitute an airblast-type injector.
    Type: Grant
    Filed: December 29, 2021
    Date of Patent: January 16, 2024
    Assignee: IHI CORPORATION
    Inventors: Takehiko Watase, Kouta Kanai, Nagayoshi Hiromitsu, Junya Kowa, Shinichiro Ishizaki, Katsuyoshi Takahashi, Tomohiro Ide, Shonosuke Kita, Mitsunori Itoh, Yuki Iwaki, Narumi Ando, Hitoshi Hattori, Kazuo Yonekura
  • LIQUID FUEL INJECTOR
    Publication number: 20220120222
    Abstract: A liquid fuel injector includes a cylindrical primary fuel injecting body having a central axis; an annular shroud concentrically placed radially outside; and an annular secondary fuel injecting body placed concentrically with the primary fuel injecting body and the shroud between the primary fuel injecting body and the shroud. A plurality of inner swirlers placed at equal intervals in a circumferential direction are provided in an annular inner air passage formed between the primary fuel injecting body and the secondary fuel injecting body, and a plurality of outer swirlers placed at equal intervals in the circumferential direction are provided in an annular outer air passage formed between the secondary fuel injecting body and the shroud. The primary fuel injecting body is formed as a pressure spray-type injector, and the secondary fuel injecting body and the inner and outer air passages cooperatively constitute an airblast-type injector.
    Type: Application
    Filed: December 29, 2021
    Publication date: April 21, 2022
    Applicant: IHI CORPORATION
    Inventors: Takehiko WATASE, Kouta KANAI, Nagayoshi HIROMITSU, Junya KOWA, Shinichiro ISHIZAKI, Katsuyoshi TAKAHASHI, Tomohiro IDE, Shonosuke KITA, Mitsunori ITOH, Yuki IWAKI, Narumi ANDO, Hitoshi HATTORI, Kazuo YONEKURA
  • Substituted aminobutyric derivatives as neprilysin inhibitors
    Patent number: 9603819
    Abstract: The present invention provides a compound of formula I?; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Grant
    Filed: March 2, 2015
    Date of Patent: March 28, 2017
    Assignee: NOVARTIS AG
    Inventors: Gary Mark Coppola, Yuki Iwaki, Rajeshri Karki, Toshio Kawanami, Gary Michael Ksander, Muneto Mogi, Robert Sun
  • SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS
    Publication number: 20150174089
    Abstract: The present invention provides a compound of formula I?; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Application
    Filed: March 2, 2015
    Publication date: June 25, 2015
    Applicant: NOVARTIS AG
    Inventors: Gary Mark COPPOLA, Yuki IWAKI, Rajeshri KARKI, Toshio KAWANAMI, Gary Michael KSANDER, Muneto MOGI, Robert SUN
  • Substituted aminobutyric derivatives as neprilysin inhibitors
    Patent number: 9006249
    Abstract: The present invention provides a compound of formula I?; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: April 14, 2015
    Assignee: Novartis AG
    Inventors: Gary Mark Coppola, Yuki Iwaki, Rajeshri Ganesh Karki, Toshio Kawanami, Gary Michael Ksander, Muneto Mogi, Robert Sun
  • Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
    Patent number: 8877786
    Abstract: The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R6, A1, A2, X1, s and m are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Grant
    Filed: December 2, 2013
    Date of Patent: November 4, 2014
    Assignee: Novartis AG
    Inventors: Yuki Iwaki, Toshio Kawanami, Gary Michael Ksander, Muneto Moji
  • SUBSTITUTED AMINOPROPIONIC DERIVATIVES AS NEPRILYSIN INHIBITORS
    Publication number: 20140296240
    Abstract: The present invention provides a compound of formula I?; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, B1, X and n are defined herein. The invention also relates a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Application
    Filed: June 17, 2014
    Publication date: October 2, 2014
    Inventors: Gary Mark COPPOLA, Yuki IWAKI, Rajeshri Ganesh KARKI, Toshio KAWANAMI, Gary Michael KSANDER, Muneto MOGI, Robert SUN
  • Substituted aminopropionic derivatives as neprilysin inhibitors
    Patent number: 8822534
    Abstract: The present invention provides a compound of formula I?; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, B1, X and n are defined herein. The invention also relates a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: September 2, 2014
    Assignee: Novartis AG
    Inventors: Yuki Iwaki, Rajeshri Ganesh Karki, Gary Michael Ksander
  • Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
    Publication number: 20140088165
    Abstract: The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R6, A1, A2, X1, s and m are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Application
    Filed: December 2, 2013
    Publication date: March 27, 2014
    Applicant: NOVARTIS AG
    Inventors: Yuki Iwaki, Toshio KAWANAMI, Gary Michael Ksander, Muneto Moji
  • Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
    Patent number: 8642635
    Abstract: The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R6, A1, A2, X1, s and m are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Grant
    Filed: December 5, 2012
    Date of Patent: February 4, 2014
    Assignee: Novartis AG
    Inventors: Yuki Iwaki, Toshio Kawanami, Gary Michael Ksander, Muneto Mogi
  • 4-benzylamino-1-carboxylacyl-piperidine derivatives as CETP inhibitors
    Patent number: 8440682
    Abstract: The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R5, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: May 14, 2013
    Assignee: Novartis AG
    Inventors: Muneto Mogi, Ken Yamada, Kayo Yasoshima, Toshio Kawanami, Ichiro Umemura, Yuki Iwaki, Hongbo Qin, Hidetomo Imase
  • Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
    Publication number: 20130096168
    Abstract: The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R6, A1, A2, X1, s and m are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Application
    Filed: December 5, 2012
    Publication date: April 18, 2013
    Applicant: NOVARTIS AG
    Inventors: Yuki IWAKI, Toshio KAWANAMI, Gary Michael KSANDER, Muneto MOGI
  • Method of inhibiting CETP activity with 4-benzylamino-1-carboxylacyl-piperidine derivatives
    Patent number: 8420641
    Abstract: The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R5, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: April 16, 2013
    Assignee: Novartis AG
    Inventors: Muneto Mogi, Ken Yamada, Kayo Yasoshima, Toshio Kawanami, Ichiro Umemura, Yuki Iwaki, Hongbo Qin, Hidetomo Imase
  • Bicyclic derivatives as CETP inhibitors
    Patent number: 8410275
    Abstract: The present invention relates to novel compounds of formula (I) or a pharmaceutical composition thereof, with all the variables being defined in the text. The present invention further relates to the use of the compounds herein for treatment of or delay progression to overt to diseases in which CETP is involved.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: April 2, 2013
    Assignee: Novartis AG
    Inventors: Masashi Kishida, Naoko Matsuura, Hidetomo Imase, Yuki Iwaki, Ichiro Umemura, Osamu Ohmori, Eiji Kawahara
  • Substituted aminopropionic derivatives as neprilysin inhibitors
    Patent number: 8394853
    Abstract: The present invention provides a compound of formula I?; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, B1, X and n are defined herein. The invention also relates a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: March 12, 2013
    Assignee: Novartis AG
    Inventors: Gary Mark Coppola, Yuki Iwaki, Rajeshri Ganesh Karki, Toshio Kawanami, Gary Michael Ksander, Muneto Mogi, Robert Sun
  • Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
    Patent number: 8377978
    Abstract: The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R6, A1, A2, X1, s and m are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: February 19, 2013
    Assignee: Novartis AG
    Inventors: Yuki Iwaki, Toshio Kawanami, Gary Michael Ksander, Muneto Mogi
  • ORGANIC COMPOUNDS
    Publication number: 20120264773
    Abstract: The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R5, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.
    Type: Application
    Filed: June 7, 2012
    Publication date: October 18, 2012
    Applicant: NOVARTIS AG
    Inventors: Muneto MOGI, Ken YAMADA, Kayo YASOSHIMA, Toshio KAWANAMI, Ichiro UMEMURA, Yuki IWAKI, Hongbo QIN, Hidetomo IMASE
  • Substituted Aminobutyric Derivatives as Neprilysin Inhibitors
    Publication number: 20120252830
    Abstract: The present invention provides a compound of formula I?; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Application
    Filed: June 7, 2012
    Publication date: October 4, 2012
    Applicant: NOVARTIS AG
    Inventors: Gary Mark Coppola, Yuki Iwaki, Rajeshri Ganesh Karki, Toshio Kawanami, Gary Michael Ksander, Muneto Mogi, Robert Sun
  • Substituted aminobutyric derivatives as neprilysin inhibitors
    Patent number: 8263629
    Abstract: The present invention provides a compound of formula I?; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: September 11, 2012
    Assignee: Novartis AG
    Inventors: Gary Mark Coppola, Yuki Iwaki, Rajeshri Ganesh Karki, Toshio Kawanami, Gary Michael Ksander, Muneto Mogi, Robert Sun
  • BICYCLIC DERIVATIVES AS CETP INHIBITORS
    Publication number: 20120225874
    Abstract: The present invention relates to novel compounds of formula (I) or a pharmaceutical composition thereof, with all the variables being defined in the text. The present invention further relates to the use of the compounds herein for treatment of or delay progression to overt to diseases in which CETP is involved.
    Type: Application
    Filed: May 17, 2012
    Publication date: September 6, 2012
    Applicant: NOVARTIS AG
    Inventors: Masashi KISHIDA, Naoko MATSUURA, Hidetomo IMASE, Yuki IWAKI, Ichiro UMEMURA, Osamu OHMORI, Eiji KAWAHARA