Abstract: A technique for enhancing functions such as proliferation ability and imparting an activity of capturing cytokines which may cause side effects in immune cells for use in the adoptive immunotherapy is disclosed. A chimeric cytokine receptor having a ligand-binding region with a cytokine-binding region of a cytokine receptor at the N-terminal side and a T-cell activating region having the transmembrane domain and the intracellular domain of an IL-7 receptor ? chain at the C-terminal side is provided. Amino acid sequence SEQ ID NO: 1 of the transmembrane domain has an insertion of one of: (a) amino acid sequence SEQ ID NO: 2 between positions 243 and 244, (b) amino acid sequence SEQ ID NO: 3 between positions 241 and 242, (c) amino acid sequence SEQ ID NO: 4 between positions 244 and 245, (d) amino acid sequence of SEQ ID NO: 5 between positions 244 and position 245, or (e) amino acid sequence of SEQ ID NO: 6 between positions 246 and 247.

Abstract: Disclosed herein are chimeric antigen receptors (CARs) comprising an intracellular segment comprising an interleukin receptor chain, a JAK-binding motif, a Signal Transducer and Activator of Transcription (STAT) 5 association motif and/or a CD3? intracellular signaling domain comprising an exogenous STAT3 association motif, as well as cells and 5 compositions comprising said CARs and uses thereof.

Abstract: Disclosed herein are chimeric antigen receptors (CARs) comprising an intracellular segment comprising an interleukin receptor chain, a JAK-binding motif, a Signal Transducer and Activator of Transcription (STAT) 5 association motif and/or a CD3? intracellular signaling domain comprising an exogenous STAT3 association motif, as well as cells and 5 compositions comprising said CARs and uses thereof.

Abstract: Disclosed herein are chimeric antigen receptors (CARs) comprising an intracellular segment comprising an interleukin receptor chain, a JAK-binding motif, a Signal Transducer and Activator of Transcription (STAT) 5 association motif and/or a CD3? intracellular signaling domain comprising an exogenous STAT3 association motif, as well as cells and 5 compositions comprising said CARs and uses thereof.

Abstract: Disclosed herein are chimeric antigen receptors (CARs) comprising an intracellular segment comprising an interleukin receptor chain, a JAK-binding motif, a Signal Transducer and Activator of Transcription (STAT) 5 association motif and/or a CD3? intracellular signaling domain comprising an exogenous STAT3 association motif, as well as cells and 5 compositions comprising said CARs and uses thereof.