Abstract: The present invention relates to an inhibitor against the stem cells of chronic myeloid leukemia (CML), a pharmaceutical composition for the treatment of CML having preventive effect on CML recurrence, a method of preventing CML recurrence, and a method of assessing the efficacy of treatment with a drug in a patient with CML, including a step of determining the expression level of latexin.

Abstract: The present invention provides: a method for identifying a blood cancer patient who may benefit from a monotherapy using a drug comprising a DNA methyl transferase inhibitor and a combination therapy using the aforesaid drug together with another epigenetic controller; a pharmaceutical composition to be used in treating a patient who has been identified or selected by the method; and a kit for identifying such a patient. More particularly, the aforesaid method comprises a step for measuring the expression amount of DUSP5 in a sample obtained from a blood cancer patient. When the expression amount measured in this step is lower than a reference expression amount of DUSP5, then the patient is identified or selected as a blood cancer patient who may benefit from a treatment using the drug comprising a DNA methyl transferase inhibitor.

Abstract: An image detection device includes: a liquid resonant lens system whose focal point is cyclically changed; an image detector configured to detect an image of an object through the lens system; a pulsed illuminator configured to provide pulsed illumination to the object in synchronization with the focal point; and an illumination controller configured to control the pulsed illuminator, in which the pulsed illuminator includes a main illumination section and a supplementary illumination section, and the illumination controller is configured to provide pulsed illumination to the object with the main illumination section and supplement illuminance on the object with the supplementary illumination section when the illuminance on the object by the main illumination section is equal to or less than a predetermined threshold.

Abstract: A variable focal length lens device includes: a variable focal length lens whose focal length cyclically changes in accordance with an inputted drive signal; an image detector configured to detect an image of a measurement target through the variable focal length lens; a pulsed light illuminator configured to emit a pulsed light to illuminate the measurement target; and an illumination controller configured to control the pulsed light illuminator so that the pulsed light is emitted twice in one cycle of the drive signal based on two detection phases corresponding to a designated focal distance of the variable focal length lens.

Abstract: An image detection device includes a liquid resonant lens system whose focal point is cyclically changeable; an image detector configured to detect a detection image in a to-be-imaged region through the lens system; a pulsed illuminator configured to emit pulsed light on the to-be-imaged region in synchronization with the focal point; and an illumination controller configured to increase or decrease an illumination duration of the pulsed illuminator depending on a required light volume of the to-be-imaged region at the focal point where the pulsed illuminator emits pulsed light.

Abstract: [Problems] The object is to provide a compound as a therapeutic or prophylactic agent for TKI-resistant CML to replace the injection “Dacogen®” which has been clinically used as a therapeutic agent for high-risk myelodysplastic syndrome and acute myeloid leukemia. The said compound has remarkable stability against cytidine deaminase, a hydrolytic enzyme, and is absorbed in vivo even by oral administration, incorporated into the biosynthesis route of nucleic acid, and exhibits the effect of inhibiting DNA methyltransferase (DNMT).

Abstract: A variable focal length lens device includes: a lens system of a liquid resonant type whose refractive index is changed in response to a drive signal to be inputted; a temperature sensor configured to acquire temperature information of the lens system; and a drive controller configured to control the lens system. The drive controller includes: a resonant frequency estimation unit configured to calculate an estimated value of a resonant frequency of the lens system on a basis of the temperature information; and a starting frequency setting unit configured to set a starting frequency of the lens system on a basis of the estimated value of the resonant frequency.

Abstract: A variable focal length lens apparatus includes a liquid lens apparatus in which the refractive index changes in accordance with an input drive signal, and a refractive power controller that controls refractive power of the lens system. The refractive power controller adjusts the voltage of the drive signal in accordance with effective power that is supplied to the liquid lens apparatus.

Abstract: An image measurement apparatus, which functions as a non-contact profile-measuring device, includes: an image sensor as an image pick-up device; a variable focal length lens (liquid lens unit) disposed on an optical axis extending from a workpiece to the image sensor; and a controller (image-pickup lens controller and image measurement processor) configured to control the variable focal length lens and process a detected image by the image sensor. The image measurement apparatus, which also functions as a non-contact displacement-detecting device, includes: an image sensor; a variable focal length lens (liquid lens unit) disposed on an optical axis extending from the workpiece to the image sensor; and a controller (displacement-detection lens controller and profile measurement processor) configured to control the variable focal length lens and a detected image by the image sensor.

Abstract: A variable focal length lens device includes: a lens system of a liquid resonant type whose refractive index is changed in response to a drive signal to be inputted; a temperature sensor configured to acquire temperature information of the lens system; and a drive controller configured to control the lens system. The drive controller includes: a resonant frequency estimation unit configured to calculate an estimated value of a resonant frequency of the lens system on a basis of the temperature information; and a starting frequency setting unit configured to set a starting frequency of the lens system on a basis of the estimated value of the resonant frequency.

Abstract: A variable focal length lens device includes: a variable focal length lens whose focal length cyclically changes in accordance with an inputted drive signal; an image detector configured to detect an image of a measurement target through the variable focal length lens; a pulsed light illuminator configured to emit a pulsed light to illuminate the measurement target; and an illumination controller configured to control the pulsed light illuminator so that the pulsed light is emitted twice in one cycle of the drive signal based on two detection phases corresponding to a designated focal distance of the variable focal length lens.

Abstract: An image detection device includes: a liquid resonant lens system whose focal point is cyclically changed; an image detector configured to detect an image of an object through the lens system; a pulsed illuminator configured to provide pulsed illumination to the object in synchronization with the focal point; and an illumination controller configured to control the pulsed illuminator, in which the pulsed illuminator includes a main illumination section and a supplementary illumination section, and the illumination controller is configured to provide pulsed illumination to the object with the main illumination section and supplement illuminance on the object with the supplementary illumination section when the illuminance on the object by the main illumination section is equal to or less than a predetermined threshold.

Abstract: An image detection device includes a liquid resonant lens system whose focal point is cyclically changeable; an image detector configured to detect a detection image in a to-be-imaged region through the lens system; a pulsed illuminator configured to emit pulsed light on the to-be-imaged region in synchronization with the focal point; and an illumination controller configured to increase or decrease an illumination duration of the pulsed illuminator depending on a required light volume of the to-be-imaged region at the focal point where the pulsed illuminator emits pulsed light.

Abstract: A variable focal length lens device includes: a lens system whose refractive index changes in accordance with an inputted drive signal; and a resonance-lock controller that locks the drive signal to a resonance frequency of the lens system. The resonance-lock controller tunes a frequency of the drive signal to a peak position of a voltage-current phase difference between a voltage of the drive signal and a drive current of the lens system, and raises or lowers the frequency of the drive signal in accordance with the drive current when the voltage-current phase difference changes.

Abstract: An image measurement apparatus, which functions as a non-contact profile-measuring device, includes: an image sensor as an image pick-up device; a variable focal length lens (liquid lens unit) disposed on an optical axis extending from a workpiece to the image sensor; and a controller (image-pickup lens controller and image measurement processor) configured to control the variable focal length lens and process a detected image by the image sensor. The image measurement apparatus, which also functions as a non-contact displacement-detecting device, includes: an image sensor; a variable focal length lens (liquid lens unit) disposed on an optical axis extending from the workpiece to the image sensor; and a controller (displacement-detection lens controller and profile measurement processor) configured to control the variable focal length lens and a detected image by the image sensor.

Abstract: A variable focal length lens apparatus includes a lens system where a refractive index changes in response to an input drive signal; a field lens arranged on the same optical axis as the lens system; an image detector detecting an image of a measured object through the lens system and the field lens; a pulse illuminator providing pulse illumination of the measured object based on an input light emission signal; a temperature sensor detecting temperature information for an interior of the lens system; and a controller outputting the drive signal and the light emission signal in addition to correcting the timing of the light emission signal based on the temperature information.

Abstract: A variable focal length lens apparatus includes a liquid lens apparatus in which the refractive index changes in accordance with an input drive signal, and a refractive power controller that controls refractive power of the lens system. The refractive power controller adjusts the voltage of the drive signal in accordance with effective power that is supplied to the liquid lens apparatus.

Abstract: A jig includes three columnar members, a stylus head receiving member, and a jig fixation portion. The second columnar member extends in a Z direction. The first columnar member extends in an X direction and is configured as a cantilever beam protruding in the X direction by having a first end of the first columnar member joined to a first end of the second columnar member. The third columnar member extends in the X direction and is configured as a cantilever beam protruding in the same direction as the first columnar member by having a first end of the third columnar member joined to a second end of the second columnar member. The stylus head receiving member is joined to the third columnar member such that a surface where a stylus head at a forefront end of a spindle of a gauge makes contact faces the first columnar member. The jig fixation portion is provided to the first columnar member so as to be attachable to a measurement spindle of the gauge inspection machine.

Abstract: A variable focal length lens device includes: a lens system whose refractive index changes in accordance with an inputted drive signal; and a resonance-lock controller that locks the drive signal to a resonance frequency of the lens system. The resonance-lock controller tunes a frequency of the drive signal to a peak position of a voltage-current phase difference between a voltage of the drive signal and a drive current of the lens system, and raises or lowers the frequency of the drive signal in accordance with the drive current when the voltage-current phase difference changes.

Abstract: A variable focal length lens apparatus includes a lens system where a refractive index changes in response to an input drive signal; a field lens arranged on the same optical axis as the lens system; an image detector detecting an image of a measured object through the lens system and the field lens; a pulse illuminator providing pulse illumination of the measured object based on an input light emission signal; a temperature sensor detecting temperature information for an interior of the lens system; and a controller outputting the drive signal and the light emission signal in addition to correcting the timing of the light emission signal based on the temperature information.