Patents by Inventor Yuki NUMAKURA

Yuki NUMAKURA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240285547
    Abstract: In one embodiment, the object of the present invention is to provide a nephrotoxicity reducing agent for a pharmaceutical composition comprising an antisense oligomer, and a method for reducing nephrotoxicity of the pharmaceutical composition. In one embodiment, the present invention relates to a nephrotoxicity reducing agent for a pharmaceutical composition comprising an antisense oligomer, wherein the nephrotoxicity reducing agent comprises a sugar alcohol and is used in an amount such that the concentration of the sugar alcohol in the pharmaceutical composition is 1 mg/ml to 400 mg/mL.
    Type: Application
    Filed: July 8, 2022
    Publication date: August 29, 2024
    Applicants: Nippon Shinyaku Co., Ltd., National University Corporation Kobe University
    Inventors: Satoru SONOKE, Kae FUJIWARA, Youhei SATOU, Tatsushi WAKAYAMA, Hirofumi MASUDA, Ryosuke SEKI, Takuma MATSUBARA, Yuki NUMAKURA, Kentaro OKAMOTO, Tatsushi TODA, Mariko IKEDA, Kazuhiro KOBAYASHI
  • Publication number: 20240285770
    Abstract: In one embodiment, the object of the present invention is to provide a precipitation suppressing agent for an antisense oligomer in urine of a subject to whom a pharmaceutical composition comprising an antisense oligomer has been administered, and a method for suppressing precipitation of an antisense oligomer in urine, in a subject to whom the pharmaceutical composition has been administered. In one embodiment, the present invention relates to a precipitation suppressing agent for an antisense oligomer in urine of a subject to whom a pharmaceutical composition comprising an antisense oligomer has been administered, wherein the precipitation suppressing agent comprises a sugar other than glucose and is used in an amount such that the concentration of the sugar in the pharmaceutical composition is 0.5 mg/mL to 3000 mg/mL.
    Type: Application
    Filed: July 8, 2022
    Publication date: August 29, 2024
    Applicant: Nippon Shinyaku Co., Ltd.
    Inventors: Yukiko ENYA, Yuki NUMAKURA, Kentaro OKAMOTO, Kazuki AGATA