Patents by Inventor Yuki Okumura
Yuki Okumura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8207189Abstract: A compound represented by the following formula or a salt thereof: wherein each of A1, A2, A3 and A4 independently represents a carbon or nitrogen, R1 is a radioactive halogen substituent, R2 is a group selected from the group consisting of hydrogen, a hydroxyl group, a methoxy group, a carboxyl group, an amino group, an N-methylamino group, an N,N-dimethylamino group and a cyano group, and p is an integer of 0 to 2, provided at least one of A1, A2, A3 and A4 represents a carbon, and R1 binds to a carbon represented by A1, A2, A3 or A4, is effective as an image diagnosis probe targeting amyloid. A diagnostic agent for Alzheimer's disease contains the compound.Type: GrantFiled: August 16, 2007Date of Patent: June 26, 2012Assignee: Nihon Medi-Physics Co., Ltd.Inventors: Shigeyuki Tanifuji, Daisaku Nakamura, Shinya Takasaki, Yuki Okumura
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Patent number: 8148664Abstract: A sheath heater for a glow plug comprises a sheath tube having a closed front end portion, and an open rear end portion. An insulating powder is charged into a gap between the sheath tube and a heat-generating resistor disposed within the sheath tube. A seal member includes an expanded portion extending radially outwardly from an outer circumference of the seal member, and a non-expanded portion of a smaller outside diameter than the expanded portion and formed on the outer circumference of the seal member at least at a leading end of the seal member. The seal member is fitted into the open rear end portion of the sheath tube such that the leading end enters the sheath tube first. The sheath tube is deformed radially inwardly around the seal member for sealing the heat-generating resistor and the insulating powder contained in the sheath tube.Type: GrantFiled: October 3, 2008Date of Patent: April 3, 2012Assignee: NGK Spark Plug Co., Ltd.Inventors: Yuki Okumura, Shuei Ishii
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Publication number: 20100292479Abstract: A compound effective as a probe targeting amyloid for image diagnosis and a reagent comprising the compound for detecting amyloid deposited on a biological tissue are provided. Provided are a compound represented by the following formula (1): wherein R1, R2 and R3 independently represent a group selected from the group consisting of a hydrogen, hydroxyl group, alkyl substituent with 1 to 4 carbon atoms, alkoxy substituent having alkyl chain with 1 to 4 carbon atoms and halogen substituent, excluding the case where two or more of the substituents R1, R2 and R3 are hydrogen, R4 is a group selected from the group consisting of a hydrogen, hydroxyl group, alkoxy substituent having alkyl chain with 1 to 4 carbon atoms and halogen substituent, and m is an integer of 1 to 4, provided that at least one of R1, R2, R3 and R4 represents a radioactive halogen substituent, and a reagent comprising the same.Type: ApplicationFiled: October 24, 2008Publication date: November 18, 2010Applicant: NIHON MEDI-PHYSICS CO., LTD.Inventors: Shigeyuki Tanifuji, Daisaku Nakamura, Shinya Takasaki, Yuki Okumura
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Publication number: 20100249408Abstract: The invention provides a reagent for detecting amyloid in a biological tissue which can detect amyloid in vitro and in vivo with high sensitivity using a compound which has affinity with amyloid and is suppressed in toxicity such as mutagenicity. The reagent for detecting amyloid deposited in a biological tissue comprises the compound represented by the following formula (1) or a salt thereof: wherein A1, A2, A3 and A4 independently represent a carbon or a nitrogen, and R3 is a group represented by the following formula: wherein R1 is a radioactive halogen substituent; m is an integer of 0 to 4; and n is an integer of 0 or 1, provided that at least one of A1, A2, A3 and A4 represents a carbon, and R3 binds to a carbon represented by A1, A2, A3 or A4.Type: ApplicationFiled: October 28, 2008Publication date: September 30, 2010Applicant: NIHON MEDI-PHYSICS CO., LTD.Inventors: Shigeyuki Tanifuji, Daisaku Nakamura, Shinya Takasaki, Yuki Okumura
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Publication number: 20100249419Abstract: The invention provides a reagent for detecting amyloid deposited in a biological tissue which can detect amyloid in vitro and in vivo with high sensitivity using a compound which has affinity with amyloid and is suppressed in toxicity such as mutagencity. The reagent for detecting amyloid deposited in a biological tissue comprises a compound represented by the following formula (1) or a salt thereof: wherein A1, A2, A3 and A4 independently represent a carbon or nitrogen; R1 is a radioactive halogen substituent; R2 is a group selected from the group consisting of hydrogen, hydroxyl group, methoxy group, carboxyl group, amino group, N-methylamino group, N,N-dimethylamino group and cyano group; and m is an integer of 0 to 2, provided that at least one of A1, A2, A3 and A4 represents a carbon, and R1 binds to a carbon represented by A1, A2, A3 and A4.Type: ApplicationFiled: October 28, 2008Publication date: September 30, 2010Applicant: NIHON MEDI-PHYSICS CO., LTD.Inventors: Shigeyuki Tanifuji, Daisaku Nakamura, Shinya Takasaki, Yuki Okumura
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Publication number: 20100249418Abstract: A compound effective as a probe targeting amyloid for image diagnosis and a reagent comprising the compound for detecting amyloid deposited on a biological tissue are provided. Provided are a compound represented by the following formula (1): wherein R1 is a group selected from the group consisting of a halogen substituent, alkyl substituent with 1 to 4 carbon atoms, alkoxy substituent having alkyl chain with 1 to 4 carbon atoms and hydroxyl group, R2 is a group selected from the group consisting of a cyano substituent, alkyl substituent with 1 to 4 carbon atoms and halogen substituent, R3 is a group selected from the group consisting of a hydroxyl group, halogen substituent and substituent represented by the following formula: (wherein R4 is a hydrogen, halogen substituent or hydroxyl group, and m is an integer of 1 to 4), provided that at least one of R1, R2, R3 and R4 represents a radioactive halogen, and a reagent comprising the same.Type: ApplicationFiled: October 24, 2008Publication date: September 30, 2010Applicant: NIHON MEDI-PHYSICS CO., LTD.Inventors: Shigeyuki Tanifuji, Daisaku Nakamura, Shinya Takasaki, Yuki Okumura
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Publication number: 20100216994Abstract: The invention provides a reagent which can detect amyloid in vitro and in vivo with high sensitivity using a compound which has affinity with amyloid. The reagent for detecting amyloid deposited in a biological tissue comprises the compound represented by the following formula (1) or a salt thereof: wherein A1, A2, A3 and A4 independently represent a carbon or nitrogen, R2 is a group selected from the group consisting of a hydrogen, hydroxyl group, carboxyl group, sulfuric acid group, amino group, nitro group, cyano group, non-radioactive halogen substituent, alkyl substituent with 1 to 4 carbon atoms and alkoxy substituent with 1 to 4 carbon atoms, and R2 is a radioactive halogen substituent, provided that at least one of A1, A2, A3 and A4 represents a carbon, and R1 binds to a carbon represented by A1, A2, A3 or A4.Type: ApplicationFiled: October 28, 2008Publication date: August 26, 2010Applicant: NIHON MEDI-PHYSICS CO., LTD.Inventors: Shigeyuki Tanifuji, Daisaku Nakamura, Shinya Takasaki, Yuki Okumura
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Publication number: 20100069640Abstract: A compound represented by the following formula or a salt thereof: wherein each of A1, A2, A3 and A4 independently represents a carbon or nitrogen, R1 is a radioactive halogen substituent, R2 is a group selected from the group consisting of hydrogen, a hydroxyl group, a methoxy group, a carboxyl group, an amino group, an N-methylamino group, an N,N-dimethylamino group and a cyano group, and p is an integer of 0 to 2, provided at least one of A1, A2, A3 and A4 represents a carbon, and R1 binds to a carbon represented by A1, A2, A3 or A4, is effective as an image diagnosis probe targeting amyloid and a diagnostic agent for Alzheimer's disease.Type: ApplicationFiled: October 30, 2007Publication date: March 18, 2010Applicant: NIHON MEDI-PHYSICS COL, LTD.Inventors: Shigeyuki Tanifuji, Daisaku Nakamura, Shinya Takasaki, Yuki Okumura
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Publication number: 20090314761Abstract: A first center pole (8) is prepared in which an inserting portion (8c) capable of being inserted into an insertion receiving portion (5b) of a heating coil (5) has been formed at its distal end. In a first step, the inserting portion 8c of the first center pole (8) is inserted into the insertion receiving portion (5b) of the heating coil (5) to form an overlapping portion (10a), thereby obtaining a first glow plug intermediate body (10). Then, in a second step, as a current is applied across electrodes (81) and (82) while sandwiching the overlapping portion (10a) by the electrodes (81) and (82), the inserting portion (8c) of the first center pole (8) and the insertion receiving portion (5b) of the heating coil (5) are welded together so as to form a weld portion (10b).Type: ApplicationFiled: March 12, 2007Publication date: December 24, 2009Applicant: NGK SPARK PLUG CO., LTD.Inventors: Shuei Ishii, Yuki Okumura
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Publication number: 20090252680Abstract: A compound represented by the following formula or a salt thereof: wherein each of A1, A2, A3 and A4 independently represents a carbon or nitrogen; R1 is a group selected from the group consisting of hydrogen, hydroxyl group, carboxyl group, sulfuric acid group, amino group, nitro group, cyano group, non-radioactive halogen substituents, alkyl substituents with 1-4 carbon atoms and alkoxy substituents with 1-4 carbon atoms; and R2 is a radioactive halogen substituent, provided at least one of A1, A2, A3 and A4 represents a carbon, and R1 binds to a carbon represented by A1, A2, A3 or A4, is effective as an image diagnosis probe targeting amyloid and as well as a diagnostic agent for Alzheimer's disease including the compound represented by the above formula or a salt thereof.Type: ApplicationFiled: October 30, 2007Publication date: October 8, 2009Applicant: NIHON- MEDI-PHYSICS CO., LTDInventors: Shigeyuki Tanifuji, Daisaku Nakamura, Shinya Takasaki, Yuki Okumura
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Publication number: 20090252679Abstract: The present invention provides a compound which has affinity with amyloid, shows sufficiently rapid clearance from normal tissues and is suppressed in toxicity such as mutagencity. Provided is a compound represented by the following formula (1) or a salt thereof: wherein A1, A2, A3 and A4 independently represents a carbon or nitrogen; R1 is a halogen substituent; R2 is a halogen substituent; and m is an integer of 0 to 2, provided that at least one of R1 and R2 is a radioactive halogen substituent, at least one of A1, A2, A3 and A4 represents a carbon, and R1 binds to a carbon represented by A1, A2, A3 or A4 as well as a low-toxic diagnostic agent comprising a compound represented by the preceding formula or a salt thereof.Type: ApplicationFiled: May 15, 2007Publication date: October 8, 2009Applicant: NIHON MEDI-PHYSICS CO., LTD.Inventors: Shigeyuki Tanifuji, Daisaku Nakamura, Shinya Takasaki, Yuki Okumura
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Publication number: 20090090705Abstract: A sheath heater for a glow plug comprises a sheath tube having a closed front end portion, and an open rear end portion. An insulating powder is charged into a gap between the sheath tube and a heat-generating resistor disposed within the sheath tube. A seal member includes an expanded portion extending radially outwardly from an outer circumference of the seal member, and a non-expanded portion of a smaller outside diameter than the expanded portion and formed on the outer circumference of the seal member at least at a leading end of the seal member. The seal member is fitted into the open rear end portion of the sheath tube such that the leading end enters the sheath tube first. The sheath tube is deformed radially inwardly around the seal member for sealing the heat-generating resistor and the insulating powder contained in the sheath tube.Type: ApplicationFiled: October 3, 2008Publication date: April 9, 2009Inventors: Yuki Okumura, Shuei Ishii