Abstract: Provided is a biological sound measurement device capable of smoothly performing tasks from measurement initiation to result confirmation, that includes a sound measurement unit including a contact surface configured to be brought into contact with the body surface of a subject, a gripping portion supporting the sound measurement unit and configured to be gripped by a measurer, and a display unit provided to the gripping portion and configured to display an analysis result of a biological sound measured by the sound measurement unit. The gripping portion is configured to be gripped by the measurer in a state in which an index finger of the measurer is placed on a back surface of the sound measurement unit, and the display unit is provided on a surface of the gripping portion on the body surface side in a state in which the contact surface is in contact with the body surface.

Abstract: Provided is a biological sound measurement device capable of retaining contact with the body surface in a favorable state and improving a measurement accuracy of a biological sound. A biological sound measurement device (1) includes a sound measurement unit (3) including a sound detector (33) configured to detect a biological sound, and a contact surface (30) configured to be brought into contact with the body surface (S) of a subject, a gripping portion (10) configured to be gripped by a measurer, and a coupling member (40) having a cylindrical tubular shape and elasticity and coupling the gripping portion (10) and the sound measurement unit (3). A wiring (SG) is inserted through a hollow portion of the coupling member (40).

Abstract: Provided is a biological sound measurement device capable of smoothly performing tasks from measurement initiation to result confirmation, that includes a sound measurement unit including a contact surface configured to be brought into contact with the body surface of a subject, a gripping portion supporting the sound measurement unit and configured to be gripped by a measurer, and a display unit provided to the gripping portion and configured to display an analysis result of a biological sound measured by the sound measurement unit. The gripping portion is configured to be gripped by the measurer in a state in which an index finger of the measurer is placed on a back surface of the sound measurement unit, and the display unit is provided on a surface of the gripping portion on the body surface side in a state in which the contact surface is in contact with the body surface.

Abstract: Provided is a biological sound measurement device to improve a measurement accuracy, that includes a sound measurement unit having a contact surface configured to be brought into contact with a body surface, and a gripping portion supporting the sound measurement unit and configured to be gripped by a measurer. The gripping portion is configured to be gripped in a state in which an index finger is placed in a recessed portion, the sound measurement unit includes a sound detector, a housing forming an accommodation space accommodating the sound detector and includes an opening, and a cover closing the opening from outside the accommodation space and forming a pressure-receiving region configured to receive pressure from the body surface. The contact surface is formed by a front surface of the cover, and the opening positioned on a straight line extending in a direction of a force applied from the index finger.

Abstract: A process for efficiently producing a nucleic acid derivative by condensing a specific nitrogen-containing heterocyclic compound such as a dinitrogen 6-membered heterocyclic compound or a trinitrogen 5-membered heterocyclic compound with a pentose using a less expensive and safe reagent. Namely, a process for producing a nucleic acid derivative by condensing a dinitrogen 6-membered heterocyclic compound or a trinitrogen 5-membered heterocyclic compound with a pentose in the presence of an iron halide.

Abstract: A process for producing a compound represented by the following formula (IV): 1

Abstract: A process for efficiently producing a nucleic acid derivative by condensing a specific nitrogen-containing heterocyclic compound such as a dinitrogen 6-membered heterocyclic compound or a trinitrogen 5-membered heterocyclic compound with a pentose using a less expensive and safe reagent. Namely, a process for producing a nucleic acid derivative by condensing a dinitrogen 6-membered heterocyclic compound or a trinitrogen 5-membered heterocyclic compound with a pentose in the presence of an iron halide.

Abstract: 2-Cyanopiperazine represented by the following formula (1): ##STR1## or a salt thereof. The 2-cyanopiperazine can be produced by reacting a 2-halogenoacrylonitrile with ethylenediamine or by reacting a 2,3-dihalogenopropionitrile with ethylenediamine.The 2-cyanopiperazine is useful as an intermediate for medicaments, agricultural chemicals, etc., and optically active N-tert-butyl-2-piperazine carboxamide, which is useful as an intermediate in preparation of the HIV protease inhibitor indinavir, can be easily produced using the 2-cyanopiperazine.

Abstract: An agent for capturing metal ions, which consists essentially of a cyclic inulooligosaccharide having from 6 to 8 molecules of fructose bonded by .beta.-2,1 bonds to form a cyclic structure, wherein hydroxyl groups may all or partially be alkylated.

Abstract: A method for producing a 2,4-dihydroxyquinoline derivative of the formula: ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 is a hydrogen atom, a lower alkyl group, a lower alkoxy group or a halogen atom, and its tautomer, which comprises cyclizing an aryl malonic acid amide ester derivative of the formula: ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined above, and R.sup.5 is a lower alkyl group, by means of polyphosphoric acid.

Abstract: There is provided a novel benzylamine derivative of the formula I: ##STR1## wherein R.sup.1 represents a hydrogen atom or a methyl group, X represents a hydrogen atom, a methyl group or a tosyl group, and Y represents a hydrogen atom, a methyl group or ##STR2## in which R.sup.2 and R.sup.3 being identical or different from each other represent independently a lower alkyl group.

Abstract: A tetrahydroisoquinoline derivative represented by formula: ##STR1## wherein R.sup.1 represents hydrogen or methyl and X.sup.1, X.sup.2, Y.sup.1 and Y.sup.2 are defined as follows:(1) X.sup.1 represents --OH, ##STR2## or OR.sup.2 wherein R.sup.2 represents lower alkyl when X.sup.2, Y.sup.1 and Y.sup.2 represent hydrogen(2) X.sup.1 and X.sup.2 together form oxo (.dbd.O), when Y.sup.1 and Y.sup.2 represent hydrogen or(3) Y.sup.1 and Y.sup.2 together form oxo (.dbd.O), when X.sup.1 and X.sup.2 represent hydrogen which is useful as an intermediate in preparation of Cotarnine.

Abstract: There is provided a novel anisole derivative represented by the following formula (I): ##STR1## wherein A to D are defined as follows: (1) A, B and C are each a hydrogen atom, and D represents --OH, a halogen atom, --CO.sub.2 R.sup.1 of which R.sup.1 represents a lower alkyl group, --SO.sub.2 R.sup.2 of which R.sup.2 represents a lower alkyl group, or ##STR2## or (2) A and C are each a hydrogen atom, B is --OH, and D represents --CO.sub.2 R.sup.3 of which R.sup.3 represents a lower alkyl group; or(3) A is a hydrogen atom, B and C form an oxo group .dbd.O together, and D represents --CO.sub.2 R.sup.4 of which R.sup.4 represents a lower alkyl group; or(4) B and C are each a hydrogen atom, D is a halogen atom, and A represents --CHO.