Patents by Inventor Yukie Suma

Yukie Suma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7902249
    Abstract: Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I): wherein R1, R2, R3 and R4 each independently represent a hydrogen atom, a methyl group, an acetyl group, or a hydroxyl group, and n represents a number from 0 to 20; and a medicinal composition comprising the same. The indole long-chain alcohol (I) exhibits an excellent nerve growth promoting effect, as well as potent antioxidative and anti-tumor effects, and is therefore useful as a prophylactic and/or therapeutic agent for cerebral diseases including dementia diseases, and malignant tumors including brain tumors.
    Type: Grant
    Filed: June 3, 2008
    Date of Patent: March 8, 2011
    Assignee: Meiji Dairies Corporation
    Inventors: Bang Luu, Djalil Coowar, Masashi Yamada, Yukie Suma, Hiroto Suzuki
  • Publication number: 20080234357
    Abstract: Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I): wherein R1, R2, R3 and R4 each independently represent a hydrogen atom, a methyl group, an acetyl group, or a hydroxyl group, and n represents a number from 0 to 20; and a medicinal composition comprising the same. The indole long-chain alcohol (I) exhibits an excellent nerve growth promoting effect, as well as potent antioxidative and anti-tumor effects, and is therefore useful as a prophylactic and/or therapeutic agent for cerebral diseases including dementia diseases, and malignant tumors including brain tumors.
    Type: Application
    Filed: June 3, 2008
    Publication date: September 25, 2008
    Applicant: MEIJI DAIRIES CORPORATION
    Inventors: Bang LUU, Djalil Coowar, Masashi Yamada, Yukie Suma, Hiroto Suzuki
  • Patent number: 7407983
    Abstract: Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I): wherein R1, R2, R3 and R4 each independently represent a hydrogen atom, a methyl group, an acetyl group, or a hydroxyl group, and n represents a number from 0 to 20; and a medicinal composition comprising the same. The indole long-chain alcohol (I) exhibits an excellent nerve growth promoting effect, as well as potent antioxidative and anti-tumor effects, and is therefore useful as a prophylactic and/or therapeutic agent for cerebral diseases including dementia diseases, and malignant tumors including brain tumors.
    Type: Grant
    Filed: February 13, 2002
    Date of Patent: August 5, 2008
    Assignee: Meiji Dairies Corporation
    Inventors: Bang Luu, Djalil Coowar, Masashi Yamada, Yukie Suma, Hiroto Suzuki
  • Patent number: 7307098
    Abstract: An indole derivative represented by the following general formula (1): wherein at least one of R1, R2, R3, and R4 represents an alkoxy group containing 1 to 20 carbon atoms, and other groups of the R1, R2, R3, and R4 represent hydrogen, an alkyl group containing 1 to 6 carbon atoms, acetyl group, or hydroxyl group; and either one of X and Y represents —(CH2)nOH wherein n is an integer of 0 to 30, and the other one of the X and Y represents hydrogen atom; or a salt thereof; and a drug and an agent for promoting differentiation of a stem cell containing such indole derivative or its salt as an effective component, wherein the indole derivative (1) has action of inducing differentiation of neural stem cell specifically into a neuron, and this indole derivative is useful as a prophylactic or therapeutic drug for brain dysfunction or neuropathy caused by loss or degeneration of the neuron.
    Type: Grant
    Filed: July 22, 2003
    Date of Patent: December 11, 2007
    Assignee: Meiji Dairies Corporation
    Inventors: Bang Luu, Djalil Coowar, Ellane Mohier, Masashi Yamada, Yukie Suma, Hiroto Suzuki
  • Patent number: 7199152
    Abstract: The present invention provides a TNF-? production inhibitor containing a kavalactone as an active ingredient, which inhibitor has high safety, exerts an excellent effect of inhibiting TNF-? production, and is useful as a drug or an animal drug for preventing, ameliorating, or treating diseases such as cachexia attributed to cancer or infectious diseases, chronic rheumatoid arthritis, inflammatory diseases, osteoarthritis, systemic lupus erythematosus (SLE), rejection during bone marrow transplantation, multiple organ failure, AIDS, meningitis, hepatitis, and type-II diabetes. The present invention also provides a preventive, ameliorating, or therapeutic agent for diseases caused by abnormal production of TNF-?, the agent containing a kavalactone as an active ingredient.
    Type: Grant
    Filed: July 1, 2002
    Date of Patent: April 3, 2007
    Assignee: Meiji Dairies Corporation
    Inventors: Yoshinori Asakawa, Sachiko Okabe, Masashi Yamada, Yukie Suma, Hiroto Suzuki, Masayuki Uchida, Natsuko Murata
  • Patent number: 7166642
    Abstract: A preventive and therapeutic drug for a neurodegenerative disease containing, as an active ingredient, a cyclohexenone long-chain alcohol compound represented by formula (1) wherein each of R1, R2, and R3 represents a hydrogen atom or a methyl group; and X represents a C10–C28 alkylene group or alkenylene group. Since the compound of the present invention exhibits excellent neurite-extension ability and an inhibition effect on disorders caused by mutation in an SOD gene, it is useful as the active ingredient of a preventive and therapeutic drug for neurodegenerative diseases, inter alia, amyotrophic lateral sclerosis, and as the active ingredient of an inhibitory drug for disorders caused by mutation in an SOD gene.
    Type: Grant
    Filed: February 10, 2000
    Date of Patent: January 23, 2007
    Assignee: Meiji Dairies Corporation
    Inventors: Bang Luu, Gaby Schmitt, Florence Keyling-Bilger, Celine Girlanda-Junges, Jean-Philippe Loeffler, Bernadette Lutz-Bucher, Jose-Luis Gonzalez de Aguilar, Masashi Yamada, Yukie Suma, Philippe Chabert
  • Publication number: 20060121132
    Abstract: The present invention provides a TNF-? production inhibitor containing a kavalactone as an active ingredient, which inhibitor has high safety, exerts an excellent effect of inhibiting TNF-? production, and is useful as a drug or an animal drug for preventing, ameliorating, or treating diseases such as cachexia attributed to cancer or infectious diseases, chronic rheumatoid arthritis, inflammatory diseases, osteoarthritis, systemic lupus erythematosus (SLE), rejection during bone marrow transplantation, multiple organ failure, AIDS, meningitis, hepatitis, and type-II diabetes. The present invention also provides a preventive, ameliorating, or therapeutic agent for diseases caused by abnormal production of TNF-?, the agent containing a kavalactone as an active ingredient.
    Type: Application
    Filed: January 20, 2006
    Publication date: June 8, 2006
    Applicant: MEIJI DAIRIES CORPORATION
    Inventors: Yoshinori Asakawa, Sachiko Okabe, Masashi Yamada, Yukie Suma, Hiroto Suzuki, Masayuki Uchida, Natsuko Murata
  • Publication number: 20050261357
    Abstract: An indole derivative represented by the following general formula (1): wherein at least one of R1, R2, R3, and R4 represents an alkoxy group containing 1 to 20 carbon atoms, and other groups of the R1, R2, R3, and R4 represent hydrogen, an alkyl group containing 1 to 6 carbon atoms, acetyl group, or hydroxyl group; and either one of X and Y represents —(CH2)n OH wherein n is an integer of 0 to 30, and the other one of the X and Y represents hydrogen atom; or a salt thereof; and a drug and an agent for promoting differentiation of a stem cell containing such indole derivative or its salt as an effective component. The indole derivative (1) of the present invention has action of inducing differentiation of neural stem cell specifically into a neuron, and this indole derivative is useful as a prophylactic or therapeutic drug for brain dysfunction or neuropathy caused by loss or degeneration of the neuron.
    Type: Application
    Filed: July 22, 2003
    Publication date: November 24, 2005
    Applicant: MEIJI DAIRIES CORPORATION
    Inventors: Bang Luu, Djalil Coowar, Ellane Mohier, Masashi Yamada, Yukie Suma, Hiroto Suzuki
  • Publication number: 20050131053
    Abstract: The invention relates to a flange coupling of two pipes, in particular the pipes of an exhaust system of a motor vehicle internal combustion engine. The coupling is characterized in that: each of the flanges is formed onto the corresponding pipe by the shaping of one of the pipe regions that form the respective flanges; a first of the two flanges is configured with a first connection pipe section, which engages radially in the interior of the second flange; a sealing ring is clamped between the flanges; the flanges are axially fixed by a clamping deice. The coupling is designed to be produced in an efficient manner, easy to mount and configured so that it functions reliably.
    Type: Application
    Filed: February 13, 2002
    Publication date: June 16, 2005
    Applicant: Meiji Dairies Corporation
    Inventors: Bang Luu, Djalil Coowar, Masashi Yamada, Yukie Suma, Hiroto Suzuki
  • Publication number: 20040152786
    Abstract: Provided is a preventive or remedy for diseases caused by a cerebrovascular disturbance, which comprises as an effective ingredient a cyclohexenone long-chain alcoholic compound represented by the following formula (1): [wherein, R1, R2 and R3 each independently represents H or CH3 and X represents a C10-28 alkylene or alkenylene group].
    Type: Application
    Filed: November 21, 2003
    Publication date: August 5, 2004
    Inventors: Bang Luu, Yoshihisa Kudo, Masashi Yamada, Masayuki Uchida, Yukie Suma, Hiroto Suzuki
  • Publication number: 20040115810
    Abstract: Provided is a stem-cell differentiation and induction promoter, which comprises as an effective ingredient a cyclohexenone long-chain alcoholic derivative represented by the formula (1):[wherein, R1, R2 and R3 each independently represents a hydrogen atom or a methyl group and X represents a linear or branched C10-28 alkylene or alkenylene group]. Since the cyclohexenone long-chain alcoholic derivative according to the present invention promotes differentiation-induction of stem cells into cells expressing a specific biological function, a medicament comprising the derivative is useful as a preventive or remedial drug for diseases such as nervous diseases, bone diseases, circulatory diseases and myopathy, caused by the degeneration of tissues or cells or cell death.
    Type: Application
    Filed: August 18, 2003
    Publication date: June 17, 2004
    Inventors: Bang Luu, Eliane Mohier, Masashi Yamada, Yukie Suma, Hiroto Suzuki
  • Patent number: 6608105
    Abstract: The present invention provides a TNF-&agr; production inhibitor containing a kavalactone as an active ingredient, which inhibitor has high safety, exerts an excellent effect of inhibiting TNF-&agr; production, and is useful as a drug or an animal drug for preventing, ameliorating, or treating diseases such as cachexia attributed to cancer or infectious diseases, chronic rheumatoid arthritis, inflammatory diseases, osteoarthritis, systemic lupus erythematosus (SLE), rejection during bone marrow transplantation, multiple organ failure, AIDS, meningitis, hepatitis, and type-II diabetes. The present invention also provides a preventive, ameliorating, or therapeutic agent for diseases caused by abnormal production of TNF-&agr;, the agent containing a kavalactone as an active ingredient.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: August 19, 2003
    Assignee: Meiji Dairies Corporation
    Inventors: Yoshinori Asakawa, Sachiko Okabe, Masashi Yamada, Yukie Suma, Hiroto Suzuki, Masayuki Uchida, Natsuko Murata
  • Publication number: 20020173540
    Abstract: The present invention provides a TNF-&agr; production inhibitor containing a kavalactone as an active ingredient, which inhibitor has high safety, exerts an excellent effect of inhibiting TNF-&agr; production, and is useful as a drug or an animal drug for preventing, ameliorating, or treating diseases such as cachexia attributed to cancer or infectious diseases, chronic rheumatoid arthritis, inflammatory diseases, osteoarthritis, systemic lupus erythematosus (SLE), rejection during bone marrow transplantation, multiple organ failure, AIDS, meningitis, hepatitis, and type-II diabetes. The present invention also provides a preventive, ameliorating, or therapeutic agent for diseases caused by abnormal production of TNF-&agr;, the agent containing a kavalactone as an active ingredient.
    Type: Application
    Filed: July 1, 2002
    Publication date: November 21, 2002
    Applicant: MEIJI DAIRIES CORPORATION
    Inventors: Yoshinori Asakawa, Sachiko Okabe, Masashi Yamada, Yukie Suma, Hiroto Suzuki, Masayuki Uchida, Natsuko Murata
  • Publication number: 20020077351
    Abstract: The present invention provides a TNF-&agr; production inhibitor containing a kavalactone as an active ingredient, which inhibitor has high safety, exerts an excellent effect of inhibiting TNF-&agr; production, and is useful as a drug or an animal drug for preventing, ameliorating, or treating diseases such as cachexia attributed to cancer or infectious diseases, chronic rheumatoid arthritis, inflammatory diseases, osteoarthritis, systemic lupus erythematosus (SLE), rejection during bone marrow transplantation, multiple organ failure, AIDS, meningitis, hepatitis, and type-II diabetes. The present invention also provides a preventive, ameliorating, or therapeutic agent for diseases caused by abnormal production of TNF-&agr;, the agent containing a kavalactone as an active ingredient.
    Type: Application
    Filed: August 30, 2001
    Publication date: June 20, 2002
    Applicant: MEIJI DAIRIES CORPORATION
    Inventors: Yoshinori Asakawa, Sachiko Okabe, Masashi Yamada, Yukie Suma, Hiroto Suzuki, Masayuki Uchida, Natsuko Murata
  • Patent number: 6228893
    Abstract: Described is a cyclohexenone long-chain alcohol represented by the formula (1): wherein R1, R2 and R3 each independently represents a hydrogen atom or a methyl group and X represents a C10-18 alkylene or alkenylene group. The cyclohexanone long-chain alcohol according to the present invention has excellent neurite growth stimulating effects and is therefore useful as a preventive and/or therapeutic agent for Alzheimer's disease.
    Type: Grant
    Filed: February 14, 2000
    Date of Patent: May 8, 2001
    Assignee: Meiji Milk Products Co., Ltd.
    Inventors: Bang Luu, Gaby Schmitt, Florence Keyling, Celine Junges-Girlanda, Masashi Yamada, Yukie Suma