Patents by Inventor Yukie Suma
Yukie Suma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7902249Abstract: Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I): wherein R1, R2, R3 and R4 each independently represent a hydrogen atom, a methyl group, an acetyl group, or a hydroxyl group, and n represents a number from 0 to 20; and a medicinal composition comprising the same. The indole long-chain alcohol (I) exhibits an excellent nerve growth promoting effect, as well as potent antioxidative and anti-tumor effects, and is therefore useful as a prophylactic and/or therapeutic agent for cerebral diseases including dementia diseases, and malignant tumors including brain tumors.Type: GrantFiled: June 3, 2008Date of Patent: March 8, 2011Assignee: Meiji Dairies CorporationInventors: Bang Luu, Djalil Coowar, Masashi Yamada, Yukie Suma, Hiroto Suzuki
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Publication number: 20080234357Abstract: Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I): wherein R1, R2, R3 and R4 each independently represent a hydrogen atom, a methyl group, an acetyl group, or a hydroxyl group, and n represents a number from 0 to 20; and a medicinal composition comprising the same. The indole long-chain alcohol (I) exhibits an excellent nerve growth promoting effect, as well as potent antioxidative and anti-tumor effects, and is therefore useful as a prophylactic and/or therapeutic agent for cerebral diseases including dementia diseases, and malignant tumors including brain tumors.Type: ApplicationFiled: June 3, 2008Publication date: September 25, 2008Applicant: MEIJI DAIRIES CORPORATIONInventors: Bang LUU, Djalil Coowar, Masashi Yamada, Yukie Suma, Hiroto Suzuki
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Patent number: 7407983Abstract: Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I): wherein R1, R2, R3 and R4 each independently represent a hydrogen atom, a methyl group, an acetyl group, or a hydroxyl group, and n represents a number from 0 to 20; and a medicinal composition comprising the same. The indole long-chain alcohol (I) exhibits an excellent nerve growth promoting effect, as well as potent antioxidative and anti-tumor effects, and is therefore useful as a prophylactic and/or therapeutic agent for cerebral diseases including dementia diseases, and malignant tumors including brain tumors.Type: GrantFiled: February 13, 2002Date of Patent: August 5, 2008Assignee: Meiji Dairies CorporationInventors: Bang Luu, Djalil Coowar, Masashi Yamada, Yukie Suma, Hiroto Suzuki
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Patent number: 7307098Abstract: An indole derivative represented by the following general formula (1): wherein at least one of R1, R2, R3, and R4 represents an alkoxy group containing 1 to 20 carbon atoms, and other groups of the R1, R2, R3, and R4 represent hydrogen, an alkyl group containing 1 to 6 carbon atoms, acetyl group, or hydroxyl group; and either one of X and Y represents —(CH2)nOH wherein n is an integer of 0 to 30, and the other one of the X and Y represents hydrogen atom; or a salt thereof; and a drug and an agent for promoting differentiation of a stem cell containing such indole derivative or its salt as an effective component, wherein the indole derivative (1) has action of inducing differentiation of neural stem cell specifically into a neuron, and this indole derivative is useful as a prophylactic or therapeutic drug for brain dysfunction or neuropathy caused by loss or degeneration of the neuron.Type: GrantFiled: July 22, 2003Date of Patent: December 11, 2007Assignee: Meiji Dairies CorporationInventors: Bang Luu, Djalil Coowar, Ellane Mohier, Masashi Yamada, Yukie Suma, Hiroto Suzuki
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Patent number: 7199152Abstract: The present invention provides a TNF-? production inhibitor containing a kavalactone as an active ingredient, which inhibitor has high safety, exerts an excellent effect of inhibiting TNF-? production, and is useful as a drug or an animal drug for preventing, ameliorating, or treating diseases such as cachexia attributed to cancer or infectious diseases, chronic rheumatoid arthritis, inflammatory diseases, osteoarthritis, systemic lupus erythematosus (SLE), rejection during bone marrow transplantation, multiple organ failure, AIDS, meningitis, hepatitis, and type-II diabetes. The present invention also provides a preventive, ameliorating, or therapeutic agent for diseases caused by abnormal production of TNF-?, the agent containing a kavalactone as an active ingredient.Type: GrantFiled: July 1, 2002Date of Patent: April 3, 2007Assignee: Meiji Dairies CorporationInventors: Yoshinori Asakawa, Sachiko Okabe, Masashi Yamada, Yukie Suma, Hiroto Suzuki, Masayuki Uchida, Natsuko Murata
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Patent number: 7166642Abstract: A preventive and therapeutic drug for a neurodegenerative disease containing, as an active ingredient, a cyclohexenone long-chain alcohol compound represented by formula (1) wherein each of R1, R2, and R3 represents a hydrogen atom or a methyl group; and X represents a C10–C28 alkylene group or alkenylene group. Since the compound of the present invention exhibits excellent neurite-extension ability and an inhibition effect on disorders caused by mutation in an SOD gene, it is useful as the active ingredient of a preventive and therapeutic drug for neurodegenerative diseases, inter alia, amyotrophic lateral sclerosis, and as the active ingredient of an inhibitory drug for disorders caused by mutation in an SOD gene.Type: GrantFiled: February 10, 2000Date of Patent: January 23, 2007Assignee: Meiji Dairies CorporationInventors: Bang Luu, Gaby Schmitt, Florence Keyling-Bilger, Celine Girlanda-Junges, Jean-Philippe Loeffler, Bernadette Lutz-Bucher, Jose-Luis Gonzalez de Aguilar, Masashi Yamada, Yukie Suma, Philippe Chabert
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Publication number: 20060121132Abstract: The present invention provides a TNF-? production inhibitor containing a kavalactone as an active ingredient, which inhibitor has high safety, exerts an excellent effect of inhibiting TNF-? production, and is useful as a drug or an animal drug for preventing, ameliorating, or treating diseases such as cachexia attributed to cancer or infectious diseases, chronic rheumatoid arthritis, inflammatory diseases, osteoarthritis, systemic lupus erythematosus (SLE), rejection during bone marrow transplantation, multiple organ failure, AIDS, meningitis, hepatitis, and type-II diabetes. The present invention also provides a preventive, ameliorating, or therapeutic agent for diseases caused by abnormal production of TNF-?, the agent containing a kavalactone as an active ingredient.Type: ApplicationFiled: January 20, 2006Publication date: June 8, 2006Applicant: MEIJI DAIRIES CORPORATIONInventors: Yoshinori Asakawa, Sachiko Okabe, Masashi Yamada, Yukie Suma, Hiroto Suzuki, Masayuki Uchida, Natsuko Murata
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Publication number: 20050261357Abstract: An indole derivative represented by the following general formula (1): wherein at least one of R1, R2, R3, and R4 represents an alkoxy group containing 1 to 20 carbon atoms, and other groups of the R1, R2, R3, and R4 represent hydrogen, an alkyl group containing 1 to 6 carbon atoms, acetyl group, or hydroxyl group; and either one of X and Y represents —(CH2)n OH wherein n is an integer of 0 to 30, and the other one of the X and Y represents hydrogen atom; or a salt thereof; and a drug and an agent for promoting differentiation of a stem cell containing such indole derivative or its salt as an effective component. The indole derivative (1) of the present invention has action of inducing differentiation of neural stem cell specifically into a neuron, and this indole derivative is useful as a prophylactic or therapeutic drug for brain dysfunction or neuropathy caused by loss or degeneration of the neuron.Type: ApplicationFiled: July 22, 2003Publication date: November 24, 2005Applicant: MEIJI DAIRIES CORPORATIONInventors: Bang Luu, Djalil Coowar, Ellane Mohier, Masashi Yamada, Yukie Suma, Hiroto Suzuki
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Publication number: 20050131053Abstract: The invention relates to a flange coupling of two pipes, in particular the pipes of an exhaust system of a motor vehicle internal combustion engine. The coupling is characterized in that: each of the flanges is formed onto the corresponding pipe by the shaping of one of the pipe regions that form the respective flanges; a first of the two flanges is configured with a first connection pipe section, which engages radially in the interior of the second flange; a sealing ring is clamped between the flanges; the flanges are axially fixed by a clamping deice. The coupling is designed to be produced in an efficient manner, easy to mount and configured so that it functions reliably.Type: ApplicationFiled: February 13, 2002Publication date: June 16, 2005Applicant: Meiji Dairies CorporationInventors: Bang Luu, Djalil Coowar, Masashi Yamada, Yukie Suma, Hiroto Suzuki
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Publication number: 20040152786Abstract: Provided is a preventive or remedy for diseases caused by a cerebrovascular disturbance, which comprises as an effective ingredient a cyclohexenone long-chain alcoholic compound represented by the following formula (1): [wherein, R1, R2 and R3 each independently represents H or CH3 and X represents a C10-28 alkylene or alkenylene group].Type: ApplicationFiled: November 21, 2003Publication date: August 5, 2004Inventors: Bang Luu, Yoshihisa Kudo, Masashi Yamada, Masayuki Uchida, Yukie Suma, Hiroto Suzuki
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Publication number: 20040115810Abstract: Provided is a stem-cell differentiation and induction promoter, which comprises as an effective ingredient a cyclohexenone long-chain alcoholic derivative represented by the formula (1):[wherein, R1, R2 and R3 each independently represents a hydrogen atom or a methyl group and X represents a linear or branched C10-28 alkylene or alkenylene group]. Since the cyclohexenone long-chain alcoholic derivative according to the present invention promotes differentiation-induction of stem cells into cells expressing a specific biological function, a medicament comprising the derivative is useful as a preventive or remedial drug for diseases such as nervous diseases, bone diseases, circulatory diseases and myopathy, caused by the degeneration of tissues or cells or cell death.Type: ApplicationFiled: August 18, 2003Publication date: June 17, 2004Inventors: Bang Luu, Eliane Mohier, Masashi Yamada, Yukie Suma, Hiroto Suzuki
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Patent number: 6608105Abstract: The present invention provides a TNF-&agr; production inhibitor containing a kavalactone as an active ingredient, which inhibitor has high safety, exerts an excellent effect of inhibiting TNF-&agr; production, and is useful as a drug or an animal drug for preventing, ameliorating, or treating diseases such as cachexia attributed to cancer or infectious diseases, chronic rheumatoid arthritis, inflammatory diseases, osteoarthritis, systemic lupus erythematosus (SLE), rejection during bone marrow transplantation, multiple organ failure, AIDS, meningitis, hepatitis, and type-II diabetes. The present invention also provides a preventive, ameliorating, or therapeutic agent for diseases caused by abnormal production of TNF-&agr;, the agent containing a kavalactone as an active ingredient.Type: GrantFiled: August 30, 2001Date of Patent: August 19, 2003Assignee: Meiji Dairies CorporationInventors: Yoshinori Asakawa, Sachiko Okabe, Masashi Yamada, Yukie Suma, Hiroto Suzuki, Masayuki Uchida, Natsuko Murata
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Publication number: 20020173540Abstract: The present invention provides a TNF-&agr; production inhibitor containing a kavalactone as an active ingredient, which inhibitor has high safety, exerts an excellent effect of inhibiting TNF-&agr; production, and is useful as a drug or an animal drug for preventing, ameliorating, or treating diseases such as cachexia attributed to cancer or infectious diseases, chronic rheumatoid arthritis, inflammatory diseases, osteoarthritis, systemic lupus erythematosus (SLE), rejection during bone marrow transplantation, multiple organ failure, AIDS, meningitis, hepatitis, and type-II diabetes. The present invention also provides a preventive, ameliorating, or therapeutic agent for diseases caused by abnormal production of TNF-&agr;, the agent containing a kavalactone as an active ingredient.Type: ApplicationFiled: July 1, 2002Publication date: November 21, 2002Applicant: MEIJI DAIRIES CORPORATIONInventors: Yoshinori Asakawa, Sachiko Okabe, Masashi Yamada, Yukie Suma, Hiroto Suzuki, Masayuki Uchida, Natsuko Murata
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Publication number: 20020077351Abstract: The present invention provides a TNF-&agr; production inhibitor containing a kavalactone as an active ingredient, which inhibitor has high safety, exerts an excellent effect of inhibiting TNF-&agr; production, and is useful as a drug or an animal drug for preventing, ameliorating, or treating diseases such as cachexia attributed to cancer or infectious diseases, chronic rheumatoid arthritis, inflammatory diseases, osteoarthritis, systemic lupus erythematosus (SLE), rejection during bone marrow transplantation, multiple organ failure, AIDS, meningitis, hepatitis, and type-II diabetes. The present invention also provides a preventive, ameliorating, or therapeutic agent for diseases caused by abnormal production of TNF-&agr;, the agent containing a kavalactone as an active ingredient.Type: ApplicationFiled: August 30, 2001Publication date: June 20, 2002Applicant: MEIJI DAIRIES CORPORATIONInventors: Yoshinori Asakawa, Sachiko Okabe, Masashi Yamada, Yukie Suma, Hiroto Suzuki, Masayuki Uchida, Natsuko Murata
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Patent number: 6228893Abstract: Described is a cyclohexenone long-chain alcohol represented by the formula (1): wherein R1, R2 and R3 each independently represents a hydrogen atom or a methyl group and X represents a C10-18 alkylene or alkenylene group. The cyclohexanone long-chain alcohol according to the present invention has excellent neurite growth stimulating effects and is therefore useful as a preventive and/or therapeutic agent for Alzheimer's disease.Type: GrantFiled: February 14, 2000Date of Patent: May 8, 2001Assignee: Meiji Milk Products Co., Ltd.Inventors: Bang Luu, Gaby Schmitt, Florence Keyling, Celine Junges-Girlanda, Masashi Yamada, Yukie Suma