Patents by Inventor Yukihiko KUDO

Yukihiko KUDO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220101956
    Abstract: A processing apparatus for processing information relating an analysis, includes a display controller that causes a display device to display first information, which is information about each substance in regard to the analysis of a sample, and second information which is information about each substance group including a plurality of the different substances in regard to the analysis, wherein the display controller displays the first information and the second information to be switchable to each other or displays the first information such that a display and a non-display of the second information are switchable.
    Type: Application
    Filed: September 10, 2021
    Publication date: March 31, 2022
    Applicant: SHIMADZU CORPORATION
    Inventor: Yukihiko KUDO
  • Publication number: 20220074902
    Abstract: A detection method includes acquiring at least one first relative response factor obtained by measurement of a sample having a same component as at least one component included in a subject sample at a known concentration and a sample having at least one compound at a known concentration, or at least one first threshold value based on each of the at least one first relative response factor, measuring the subject sample and a sample including the at least one compound, and calculating at least one second relative response factor in regard to at least one component of the subject sample and the at least one compound, and producing first information in regard to a change in concentration of the subject sample based on the at least one first relative response factor or the at least one first threshold value, and the corresponding at least one second relative response factor.
    Type: Application
    Filed: January 23, 2019
    Publication date: March 10, 2022
    Applicant: SHIMADZU CORPORATION
    Inventor: Yukihiko KUDO
  • Publication number: 20220074832
    Abstract: An analysis method is a method of analyzing a second substance in a sample including the second substance produced by decomposition of a first substance, and includes analyzing a sample and a compound having a known concentration and detecting the first substance, the second substance and the above-mentioned compound, calculating an intensity or a concentration of the first substance obtained from the above-mentioned data based on data obtained by the detection and a relative response factor in regard to the first substance and the above-mentioned compound, and producing information about an amount or a concentration of the second substance excluding the second substance produced from the first substance in the analysis, based on an intensity or a concentration of the first substance.
    Type: Application
    Filed: February 7, 2019
    Publication date: March 10, 2022
    Applicant: SHIMADZU CORPORATION
    Inventor: Yukihiko KUDO
  • Publication number: 20220051885
    Abstract: A method for evaluating a mass spectrometry device includes: by a mass spectrometry device, performing mass spectrometry of an ester of phthalic acid and detecting a plurality of types of ions produced by dissociation of the ester of phthalic acid; and obtaining information concerning whether the mass spectrometry device is in a state suitable for analysis, based on a ratio of intensities of the plurality of types of ions detected.
    Type: Application
    Filed: September 28, 2018
    Publication date: February 17, 2022
    Applicant: SHIMADZU CORPORATION
    Inventors: Yukihiko KUDO, Kenichi OBAYASHI, Katsuhiro NAKAGAWA
  • Publication number: 20220050080
    Abstract: A method of evaluating an analysis device that is capable of detecting each of a plurality of compounds included in a sample includes introducing the sample including a first compound into the analysis device for measurement and detecting the first compound and at least one reaction product derived from the first compound, and acquiring information representing whether the analysis device is in a suitable state for an analysis based on an intensity of the detected first compound and an intensity of each of the detected at least one reaction product, and a relative response factor in regard to each of the first compound and the at least one reaction product.
    Type: Application
    Filed: December 17, 2018
    Publication date: February 17, 2022
    Applicant: SHIMADZU CORPORATION
    Inventor: Yukihiko KUDO
  • Publication number: 20220013344
    Abstract: An analysis method includes analyzing a reference sample that contains a predetermined amount of a predetermined component by an analysis device using a chromatograph and obtaining a reference detection value which is a detection value of the predetermined amount of the predetermined component detected by the analysis device, calculating a judgment reference value which is a criterion for judging whether a concentration of a detection subject component in a measurement subject sample is equal to or larger than a reference concentration or equal to or smaller than the reference concentration based on the reference detection value, and analyzing the measurement subject sample by the analysis device and judging that the detection subject component has been detected in a case where a detection value exceeding the judgment reference value is detected in a peak detection time zone corresponding to the detection subject component.
    Type: Application
    Filed: November 20, 2019
    Publication date: January 13, 2022
    Applicant: SHIMADZU CORPORATION
    Inventors: Yukihiko KUDO, Shinji SUGIMOTO
  • Publication number: 20210132013
    Abstract: A mass spectrum generation section (22) generates an original mass spectrum at a peak of a target compound based on data acquired through analysis on a sample. A background spectrum generation section (23) generates a background spectrum in accordance with each of a plurality of predetermined background acquisition conditions. A difference mass spectrum calculation section (25) obtains a difference mass spectrum by subtracting the each background spectrum from the original mass spectrum, and a spectrum similarity calculation section (27) calculates a similarity between each difference mass spectrum and a standard mass spectrum of a candidate compound selected from a spectrum library (28). A compound identification section (29) identifies the candidate compound as the target compound if the highest similarity exceeds a predetermined threshold.
    Type: Application
    Filed: January 30, 2017
    Publication date: May 6, 2021
    Applicant: SHIMADZU CORPORATION
    Inventors: Kazuhiro KAWAMURA, Yukihiko KUDO
  • Publication number: 20210116429
    Abstract: A response factor that is a signal strength ratio with respect to a reference compound for various compounds is previously stored in a response factor storage (22). When an operator instructs to estimate an analysis limit value, a measurement unit (1) performs GC-MS analysis on a sample containing the reference compound a plurality of times under control of an analysis controller (3). A signal strength calculator (23) obtains a signal strength value of the reference compound based on an analysis result of the measurement unit (1), a relative strength calculator (24) calculates a relative standard deviation from the plurality of measured signal strength values, and calculates the relative standard deviation of a target compound from the response factor of the target compound read from the response factor storage (22).
    Type: Application
    Filed: April 25, 2017
    Publication date: April 22, 2021
    Applicant: SHIMADZU CORPORATION
    Inventor: Yukihiko KUDO
  • Patent number: 10928363
    Abstract: At least one stable isotope reagent is added to each biological sample and standard sample to prepare biological samples for analysis and standard sample for analysis. The quality of the biological samples is evaluated using data of one set of biological samples for analysis composed of a plurality of biological samples for analysis. Besides, the quality of a pretreatment and/or analysis of each set of samples for analysis is evaluated using data obtained by analyzing the standard sample for analysis before and after an analysis of one set of samples for analysis. An abnormality in a chromatograph or mass analyzer used for the analysis of one set of samples is evaluated by the data obtained by analyzing a sample for device evaluation before and after the analysis of one set of samples for analysis. Thus, the quality of data obtained by chromatographic mass spectrometry on biological samples is comprehensively evaluated.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: February 23, 2021
    Assignees: SHIMADZU CORPORATION, NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY
    Inventors: Noriyuki Ojima, Shuichi Kawana, Yumi Unno, Takero Sakai, Kenichi Obayashi, Yukihiko Kudo, Katsuyuki Taneda, Masaru Yoshida, Shin Nishiumi, Takashi Kobayashi, Takeshi Azuma
  • Patent number: 10845344
    Abstract: Respective peaks detected on chromatograms created based on data obtained by conducting GC-MS analysis on a target sample are identified based on information stored in a compound database (S1, S2). A retention time list indicating relationships between compounds and measured peak retention times is created based on results of identification of the peak. Then a plurality of compounds in which the measured retention times are identical to each other or are within an allowable range are extracted and are combined into one group (S3, S4). A determination is made whether overlapping identifications exist by determining whether a single group includes a plurality of compounds (S5, S6). Retention times, mass spectrums, and confirmation ion ratio reference values stored in the compound database are used for the respective groups in which overlapping identifications are likely to exist so that a most likely compound candidate is selected (S7).
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: November 24, 2020
    Assignee: SHIMADZU CORPORATION
    Inventor: Yukihiko Kudo
  • Publication number: 20200309748
    Abstract: Respective peaks detected on chromatograms created based on data obtained by conducting GC-MS analysis on a target sample are identified based on information stored in a compound database (S1, S2). A retention time list indicating relationships between compounds and measured peak retention times is created based on results of identification of the peak. Then a plurality of compounds in which the measured retention times are identical to each other or are within an allowable range are extracted and are combined into one group (S3, S4). A determination is made whether overlapping identifications exist by determining whether a single group includes a plurality of compounds (S5, S6). Retention times, mass spectrums, and confirmation ion ratio reference values stored in the compound database are used for the respective groups in which overlapping identifications are likely to exist so that a most likely compound candidate is selected (S7).
    Type: Application
    Filed: July 8, 2016
    Publication date: October 1, 2020
    Applicant: SHIMADZU CORPORATION
    Inventor: Yukihiko KUDO
  • Patent number: 10288589
    Abstract: In a mass spectrometry method for performing a qualitative and/or quantitative determination of an analyte compound contained in a sample, using a mass chromatogram acquired for one or a plurality of ions selected as a reference ion from the ions produced from the analyte compound, the present method includes the steps of: setting one or a plurality of reference-ion candidates for each of the one or a plurality of reference ions; acquiring a mass chromatogram of the sample for each of the set reference-ion candidates; calculating a shape similarity between a peak appearing at a predetermined position on the mass chromatogram and a preset model peak; and designating, as the reference ion, a reference-ion candidate corresponding to a peak having the shape similarity equal to or higher than a predetermined value.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: May 14, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Yukihiko Kudo, Kenichi Obayashi, Syuichi Kawana
  • Publication number: 20180299448
    Abstract: Provided is a colorectal cancer inspection method by which the presence of early colorectal cancer at any one of stages from 0 to 2 can be accurately determined. The colorectal cancer inspection method includes: measuring the amounts of at least lactic acid, pyruvic acid, and glycolic acid among a plurality of kinds of in vivo metabolites contained in a biological sample collected from a test subject, based on data obtained by performing a chromatograph-MS/MS analysis on the biological sample; and determining the presence of colorectal cancer at any one of stages from 0 to 2, based on a measurement value of at least one of the lactic acid, the pyruvic acid, and the glycolic acid.
    Type: Application
    Filed: February 2, 2018
    Publication date: October 18, 2018
    Applicants: SHIMADZU CORPORATION, NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY, NATIONAL CANCER CENTER
    Inventors: Noriyuki OJIMA, Shuichi KAWANA, Yumi UNNO, Takero SAKAI, Kenichi OBAYASHI, Yukihiko KUDO, Masaru YOSHIDA, Shin NISHIUMI, Takashi KOBAYASHI, Takeshi AZUMA, Koji OKAMOTO, Yasuhide YAMADA, Natsuko OKITA, Kazuki SUDO
  • Publication number: 20180284075
    Abstract: At least one stable isotope reagent is added to each biological sample and standard sample to prepare biological samples for analysis and standard sample for analysis. The quality of the biological samples is evaluated using data of one set of biological samples for analysis composed of a plurality of biological samples for analysis. Besides, the quality of a pretreatment and/or analysis of each set of samples for analysis is evaluated using data obtained by analyzing the standard sample for analysis before and after an analysis of one set of samples for analysis. An abnormality in a chromatograph or mass analyzer used for the analysis of one set of samples is evaluated by the data obtained by analyzing a sample for device evaluation before and after the analysis of one set of samples for analysis. Thus, the quality of data obtained by chromatographic mass spectrometry on biological samples is comprehensively evaluated.
    Type: Application
    Filed: February 1, 2018
    Publication date: October 4, 2018
    Applicants: SHIMADZU CORPORATION, NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY
    Inventors: Noriyuki OJIMA, Shuichi KAWANA, Yumi UNNO, Takero SAKAI, Kenichi OBAYASHI, Yukihiko KUDO, Katsuyuki TANEDA, Masaru YOSHIDA, Shin NISHIUMI, Takashi KOBAYASHI, Takeshi AZUMA
  • Publication number: 20170067864
    Abstract: In a mass spectrometry method for performing a qualitative and/or quantitative determination of an analyte compound contained in a sample, using a mass chromatogram acquired for one or a plurality of ions selected as a reference ion from the ions produced from the analyte compound, the present method includes the steps of: setting one or a plurality of reference-ion candidates for each of the one or a plurality of reference ions; acquiring a mass chromatogram of the sample for each of the set reference-ion candidates; calculating a shape similarity between a peak appearing at a predetermined position on the mass chromatogram and a preset model peak; and designating, as the reference ion, a reference-ion candidate corresponding to a peak having the shape similarity equal to or higher than a predetermined value.
    Type: Application
    Filed: March 5, 2014
    Publication date: March 9, 2017
    Applicant: SHIMADZU CORPORATION
    Inventors: Yukihiko KUDO, Kenichi OBAYASHI, Syuichi KAWANA