Patents by Inventor Yukihiko Nose
Yukihiko Nose has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 5080796Abstract: A method for more selectively removing macromolecules from a plasma solution, whereby plasma containing the macromolecules to be removed is provided and heated to a temperature near or above normal body temperature but below the boiling point of the plasma solution. The heated plasma solution is filtered while at a temperature near or above normal body temperature but below its boiling point with a membrane filter to remove selectively macromolecules from the plasma solution. An apparatus for accomplishing the foregoing is also provided.Type: GrantFiled: February 12, 1990Date of Patent: January 14, 1992Assignee: The Cleveland Clinic FoundationInventors: Yukihiko Nose', Paul S. Malchesky, Takashi Horiuchi
-
Patent number: 4966709Abstract: A method for more selectively removing macromolecules from a plasma solution, whereby plasma containing the macromolecules to be removed is provided and heated to a temperature near or above normal body temperature but below the boiling point of the plasma solution. The heated plasma solution is filtered while at a temperature near or above normal body temperature but below its boiling point with a membrane filter to remove selectively macromolecules from the plasma solution. An apparatus for accomplishing the foregoing is also provided.Type: GrantFiled: July 18, 1988Date of Patent: October 30, 1990Assignee: The Cleveland Clinic FoundationInventors: Yukihiko Nose, Paul S. Malchesky, Takashi Horiuchi
-
Patent number: 4897162Abstract: A glucose sensing apparatus and method includes an electrocatalytic sensor having a reference electrode and a sensing electrode. A periodic signal is comprised of a ramp voltage which is intermingled a series of square wave measurement pulses. This signal is applied to the sensor. Current levels are sampled twice during each measurement pulse, and a signal indicative of glucose level is derived therefrom. After completion of a measurement, a reactivation, signal is applied to the electrode to regenerate deteriorated surfaces thereof.Type: GrantFiled: February 2, 1988Date of Patent: January 30, 1990Assignee: The Cleveland Clinic FoundationInventors: Jan Lewandowski, Paul S. Malchesky, Yukihiko Nose'
-
Patent number: 4619639Abstract: A method and apparatus for carrying out separation of plasma from whole blood, in which whole blood is passed through a filtration membrane means of a material suitable for separating plasma from whole blood and having a pore size from 0.1 to 0.6 microns at positive pressure differential across the membrane in a range up to just below 50 mm Hg. This provides an increased flow as compared to the flow obtained with higher pressures.Type: GrantFiled: September 11, 1985Date of Patent: October 28, 1986Assignee: Asahi Medical Co., Ltd.Inventors: Yukihiko Nose, Paul S. Malchesky
-
Patent number: 4402940Abstract: This invention provides a method for treating blood plasma wherein a hollow fiber membrane which comprises at least a skin layer on one surface of the membrane and also a porous layer inside the membrane is employed. The skin layer of the membrane has micropores with average pore size of 50 to 450 A, and the membrane shows a water permeability of 80 ml/m.sup.2.hr.mmHg or more, and permeabilites for human blood plasma albumin of 85% or more and for human blood plasma immunoglobulin G(IgG) of 80% or more, and a rate of inhibition against human blood plasma immunoglobulin M(IgM) of 40% or more. Use of the above mentioned hollow fiber membrane, which makes it possible to selectively remove immune complex, rheumatoid factors, etc., without decrease in levels of immunological functions, brings excellent effects on therapy of autoimmune diseases.Type: GrantFiled: September 17, 1982Date of Patent: September 6, 1983Assignee: Kuraray Co., Ltd.Inventors: Yukihiko Nose, Koji Kayashima, Akinori Sueoka, Yoshihiro Asanuma, Shigeru Shinagawa, James Smith, Andrej Werynski, Paul S. Malchesky
-
Patent number: 4381775Abstract: A method for carrying out separation of plasma from whole blood, in which whole blood is passed through a filtration membrane means of a material suitable for separating plasma from whole blood and having a pore size from 0.1 to 0.6 microns at positive pressure differential across the membrane in a range up to just below 50 mm Hg. This provides an increased flow as compared to the flow obtained with higher pressures.Type: GrantFiled: August 18, 1980Date of Patent: May 3, 1983Assignee: Takeda Chemical Industries, Ltd.Inventors: Yukihiko Nose', Paul S. Malchesky
-
Patent number: 4350156Abstract: An on-line filtration system for the removal of macromolecules greater than 70,000 mol. wt. from a physiological solution, such as blood, in the therapeutic treatment of various disease states. For blood, the plasma (which contains the macromolecules) is separated continuously from the blood using a first membrane filter with a membrane porosity of nominally 0.2 to 1.0 micron. The separated plasma is then continuously filtered in a physiological temperature state or a cooled state through a second membrane filter with a membrane porosity of nominally 0.01 to 0.2 micron, which retains the macromolecules. In the cooled state, separation of the macromolecules is effected more efficiently than could be done in the non-cooled state. The treated plasma (macromolecules removed) is then reunited with the blood flow coming from the first plasma filter and returned to the patient. The blood flow and filtration processes are generally continuous.Type: GrantFiled: May 29, 1980Date of Patent: September 21, 1982Assignee: Japan Foundation for Artificial OrgansInventors: Paul S. Malchesky, Yukihiko Nose
-
Patent number: 4311587Abstract: A filter connection for peritoneal dialysis is presented including, in a flow line from a source of fresh dialysate solution carried on the patient's body, and under pressure, through a bacteria filter of sub-micron porosity for removing microorganisms generally greater than about 0.2 microns (nominal size) together with tubular connections leading from the filter toward a catheter inserted in the patient's peritoneum including in order from the filter, a first check valve permitting flow only away from the filter, then an outflow port with check valve permitting used dialysis flow only away from the patient, and finally the connection to the catheter tube.Type: GrantFiled: December 10, 1979Date of Patent: January 19, 1982Assignee: Japan Foundation for Artificial OrgansInventors: Yukihiko Nose, Paul S. Malchesky
-
Patent number: 4128479Abstract: A unit is presented for the transfer of a gaseous component in one stream to or from a liquid component in another stream, in which a membrane assembly is wound spirally around a central rigid cylindrical core. The membrane assembly comprises a continuous length of flattened tubular membrane with a gas net passing through the intermediate portion of the membrane from end to end thereof and substantially the width of the interior of the tubular membrane. In forming the coil, a net separator is wound between the membrane layers of the coil. An inlet tube for one of the components communicates with one end of the membrane and an outlet tube for the same component communicates with the other end of the membrane. Means is provided for passing another of the components longitudinally of the coil between the membrane layers from one end of the coil to the other end. The specific embodiment of a blood oxygenator is described.Type: GrantFiled: January 20, 1978Date of Patent: December 5, 1978Assignee: Japan Foundation For Artificial OrgansInventors: Paul S. Malchesky, Yukihiko Nose
-
Patent number: 4127481Abstract: Extracorporeal and implantable blood interchange devices used in providing interchange function of predetermined components with a fluid, such as for instance the removal of undesirable components from the bloodstream of a human and, characterized by capillary tubing having a reactor or sorbent material, such as activated charcoal, disposed within the lumens thereof, with the tubing being semi-permeable and with blood, or other fluid, being perfused over the capillary tubing in close physical contact with the exterior surfaces thereof, for accomplishing interchange coaction between the sorbent in the tubing and the perfusing fluid. Such tubing is arranged in rectangular configuration, with tangential entry and exit of perfused fluid.Type: GrantFiled: January 5, 1978Date of Patent: November 28, 1978Assignee: Japan Foundation for Artificial OrgansInventors: Paul S. Malchesky, Yukihiko Nose
-
Patent number: 4031010Abstract: A combined dialyzer and adsorber unit in one disposable package. The dialyzer is integral with the adsorber which contains a chemical adsorbent to regenerate a dialysate solution. In a preferred embodiment the dialyzer is mounted in the form of a sleeve around the adsorber container as a core. Dialysate is introduced into the dialyzer, then immediately circulated through the chemical adsorbent contained in the adsorber. There the major components of the impurities dialyzed out from the dialyzer can be adsorbed, whereby the dialysate is regenerated. The sleeve can be the adsorber and the core the dialyzer. In addition, the adsorber can have included therein, either mixed in with the adsorbent material or in a separate compartment, a water soluble dialysate material which can be dissolved by circulating water through the unit prior to starting to dialyze the patient.Type: GrantFiled: September 5, 1975Date of Patent: June 21, 1977Assignee: Takeda Chemical Industries, Ltd.Inventor: Yukihiko Nose
-
Patent number: 4013564Abstract: A multipurpose metabolic assist system has an inlet passageway, an outlet passageway, a treated blood component passageway spaced from the inlet passageway and extending to the outlet passageway. The system has at least one space between at least a portion of the inlet passageway and a portion of the treated blood component passageway, and a particulate treatment agent for treating a component of the blood is packed in said space. At least a portion of the inlet passageway and the treated blood collection passageway which face the space are constituted by a porous membrane having pores of a size smaller than the size of the particles of the treatment agent and of a size for passing a component of the blood to be treated, and blocking passage of the remainder of the blood. A flow obstructor for producing an increased pressure is provided in the inlet passageway.Type: GrantFiled: March 17, 1975Date of Patent: March 22, 1977Assignee: Takeda Chemical Industries, Ltd.Inventor: Yukihiko Nose