Patents by Inventor Yukihiro Akao

Yukihiro Akao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF MICRO-RNA TO IMPROVE AND TREAT CHRONIC PHASE CARDIAC FUNCTION
    Publication number: 20230288431
    Abstract: A method for assessing a chronic phase cardiac function in acute myocardial infarction, includes monitoring blood concentration of miR-143 and/or miR-145 in an acute phase of the acute myocardial infarction in an individual who has occurred the acute myocardial infarction or presents a possibility of occurrence of the acute myocardial infarction.
    Type: Application
    Filed: March 17, 2021
    Publication date: September 14, 2023
    Applicant: NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM
    Inventors: Shinya MINATOGUCHI, Yukihiro AKAO
  • INHIBITOR OF ASPARTIC ACID SYNTHESIS IN TUMOR CELLS, INHIBITOR OF SPHEROID FORMATION OF TUMOR CELLS, INHIBITOR OF TUMOR CELL METASTASIS, ACTIVITY ENHANCER OF GLYCOLYTIC INHIBITOR, AND PHARMACEUTICAL COMPOSITION FOR SUPPRESSING AND/OR PREVENTING TUMOR METASTASIS
    Publication number: 20230144898
    Abstract: Provided is a highly safe metastasis inhibitor of tumor cells that can be substituted for a conventionally known metastasis inhibitor of tumor cells. A compound represented by Chemical Formula 1A or Chemical Formula 1B described in the description is used as an aspartic acid synthesis inhibitor in tumor cells, a spheroid formation inhibitor of tumor cells, or an action enhancer of glycolysis inhibitors. These inhibitors have a function as a highly potent metastasis inhibitor of tumor cells.
    Type: Application
    Filed: February 15, 2021
    Publication date: May 11, 2023
    Inventors: Yukihiro AKAO, Kazuki HEISHIMA, Ryo ITO, Kenji HONDA
  • MicroRNA-143 derivative
    Patent number: 11041152
    Abstract: The purpose of the present invention is to provide novel miR-143 derivatives described herein that can be used as oligonucleotide therapeutics.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: June 22, 2021
    Assignees: E-NA BIOTEC INC.
    Inventors: Yukihiro Akao, Yukio Kitade, Mitsuaki Sekiguchi, Yasunori Mitsuoka, Akira Kugimiya, Yasuo Sasaki
  • Double-stranded nucleic acid molecule and use thereof
    Patent number: 10874688
    Abstract: A double-stranded nucleic acid molecule includes a first polynucleotide chain including a base sequence represented by Chemical Formula (1) (SEQ ID NO:1) and a second polynucleotide chain including a base sequence complementary to the first polynucleotide chain. A method for preventing and/or treating a tumor includes a step in which the double-stranded nucleic acid molecule is administered to a test subject.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: December 29, 2020
    Assignee: GIFU UNIVERSITY
    Inventor: Yukihiro Akao
  • DOUBLE-STRANDED NUCLEIC ACID MOLECULE AND USE THEREOF
    Publication number: 20190262378
    Abstract: A double-stranded nucleic acid molecule includes a first polynucleotide chain including a base sequence represented by Chemical Formula (1) (SEQ ID NO:1) and a second polynucleotide chain including a base sequence complementary to the first polynucleotide chain. A method for preventing and/or treating a tumor includes a step in which the double-stranded nucleic acid molecule is administered to a test subject.
    Type: Application
    Filed: October 31, 2017
    Publication date: August 29, 2019
    Inventor: Yukihiro AKAO
  • microRNA-143 DERIVATIVE
    Publication number: 20190119677
    Abstract: The purpose of the present invention is to provide novel miR-143 derivatives described herein that can be used as oligonucleotide therapeutics.
    Type: Application
    Filed: April 13, 2017
    Publication date: April 25, 2019
    Applicant: Shionogi & Co., Ltd.
    Inventors: Yukihiro AKAO, Yukio KITADE, Mitsuaki SEKIGUCHI, Yasunori MITSUOKA, Akira KUGIMIYA, Yasuo SASAKI
  • MEDICINAL COMPOSITION FOR TREATING INFARCTION
    Publication number: 20150064237
    Abstract: The present invention provides a pharmaceutical composition for treating infarction, such as myocardial infarction or cerebral infarction, with a method that is different from conventional therapeutic methods that use a thrombolytic agent or balloon therapy. An autophagy enhancer such as hsa-miR-145 is used as the active ingredient of the pharmaceutical composition for treating infarction. In particular, an autophagy enhancer such as hsa-miR-145 is used in a liposomal state as an active ingredient of the pharmaceutical composition for treating infarction.
    Type: Application
    Filed: April 12, 2013
    Publication date: March 5, 2015
    Applicants: OTSUKA PHARMACEUTICAL CO., LTD., GIFU UNIVERSITY
    Inventors: Shinya Minatoguchi, Yukihiro Akao