Abstract: The present invention is to provide a novel medicine, drink, food or feed having an action of strengthening bone. More specifically, the present invention is to provide a medicine, drink, food or feed combined with collagen, fraction containing collagen or degradation product thereof. Fraction containing collagen was prepared by mincing skin corium layer into pieces, defatting it and lyophylization or by pulverizing bone, decalcifying it and lyophylization. Oral administration of these can stimulate proliferation of osteoblast, inhibit bone resorption and strengthen bone. They can be useful for improvement of osteoporosis, bone fracture, bone pain, etc.

Abstract: The present invention provides a basic protein and a basic peptide composition which can be administered orally and has the ability to stimulate osteoblast proliferation, strengthen bone and inhibit bone resorption. Said basic protein has the following properties: (1) a molecular weight distribution of is 2,000-24,000; (2) an isoelectric point distribution of is 7.5-11; and (3) it is comprised of more than 10% of basic amino acids. Said composition can be obtained by the following steps: After milk, or raw material derived from milk, is loaded onto a cation exchange resin column, a fraction is obtained by eluting with an eluent of 0.1-1.0M salt concentration, precipitate removed by (i) heating to over 75.degree. C., (ii) by adding alcohol so that the final concentration thereof is 10-50% or (iii) by adding salts so that the final concentration thereof will be more than 0.2M; and the supernatant thereof containing the basic protein fraction recovered.

Abstract: A bone reinforcing agent comprising a basic protein fraction or a basic peptide fraction derived from milk as an effective component is described. The basic protein fraction is obtained by passing milk or a raw material derived from milk over a cation exchange resin and eluting the adhered fraction. The basic peptide fraction is obtained by hydrolyzing the basic protein fraction with a protease. The basic protein fraction and basic peptide fraction of the present invention promote the growth of osteoclasts and suppress the resorption of osteoclasts, and thereby strengthening bone when administered orally. The invention is useful for treating or preventing bone diseases such as osteoporosis.

Abstract: The present invention will provide an agent promoting bone formation and inhibiting bone resorption comprising kininogen and degradation product of kininogen as an effective ingredient. Fragment 1.multidot.2 is a preferable degradation product of kininogen.Further, the present invention will provide a drink, food, medicine and feed combined with kininogen and degradation product of kininogen.

Abstract: A method for promoting osteoblast proliferation or inhibiting bone resorption comprising administering to a subject in need thereof, a composition comprising High Mobility Group Protein (HMG-1) is disclosed.

Abstract: A hydraulic cylinder with which it is possible to promote cost reduction and weight reduction by reducing the number of parts, ensure that a sealing function is fully performed and also make possible a reduction in size comprises a cylinder tube 4, a piston 1 slidably installed inside this cylinder tube 4, a rod 6 connected to the piston, a bearing 9 supporting the rod 6, a tubular cylinder head 10 mounted in the front end of the cylinder tube and seals 12 and 13 mounted in contact with the rod 6 on an inner circumferential surface of the cylinder head 10; a cylindrical recess 19 is formed in the front end of the cylinder tube 4, the radius R of this cylindrical recess 19 is made larger by a predetermined dimension than the radius r of a piston sliding surface formed on the cylinder tube 4, a screw thread 19a is formed in this cylindrical recess 19, the cylinder head 10 is screwed into this cylindrical recess 19 and the bearing 9 supporting the rod 6 is mounted on an inner circumferential surface of this cyli

Abstract: The invention relates to an osteoblast growth and bone enhancing factor or factors having a molecular weight of about 5,000 to 28,000 daltons and an isoelectric point of 4 to 9, which is isolated from whey or whey protein. The invention includes various methods for obtaining the factor or factors from whey and whey protein. The factor or factors from whey and whey protein may be incorporated in foods, medicines and feeds for preventing or treating osteoporosis and other maladies in joints of bones.

Abstract: A product name stamping device of the label printers in which an ink-soaked member is provided to the stamp holder and a light and small ink-soaking member which contacts the ink-soaked member of the holder is fitted to the stamp. This construction make the stamp small and compact. The compactness of the stamp makes easy the handling and storage of a large number of stamps and also spares material bringing about a reduction in cost. The device is so constructed that setting the stamp into the holder automatically supplies ink to the stamp.