Patents by Inventor Yukihisa Ono

Yukihisa Ono has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for inhibiting cytokine secretion
    Patent number: 6034100
    Abstract: A method for the prophylaxis and treatment of diseases induced by acceleration of secretion of cytokines (e.g. TNF-.alpha., IL-1, IL-6, IL-8, and IFN-.gamma.) which comprises administering a benzoheterocyclic compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are lower alkyl and X.sup.1 is halogen, R.sup.3 is lower alkyl, R.sup.4 is hydroxy, and X.sup.2 is halogen, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 5, 1995
    Date of Patent: March 7, 2000
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Masakazu Adachi, Hisashi Tamaoka, Yukihisa Ono, Kazunori Omori
  • TNF-.alpha.inhibitor
    Patent number: 5886010
    Abstract: A method for the prophylaxis and treatment of diseases induced by accelerated INF-.alpha. secretion, such as rheumatoid arthritis, endotoxin shock, adult respiratory distress syndrome, thermal burn, asthma, myocardial infarction, acute phase of viral myocardiosis, etc. which comprises administering a carbostyril compound of the formula: ##STR1## wherein R.sup.1 is H or lower alkyl, and R.sup.2 is phenyl(lower)alkyl having optionally 1 to 3 lower alkoxy substituents on the phenyl ring, or a pharmaceutically acceptable salt thereof to a subject.
    Type: Grant
    Filed: July 3, 1997
    Date of Patent: March 23, 1999
    Assignee: Otsuka Pharmaceutical Company, Limited
    Inventors: Toyoki Mori, Michiaki Tominaga, Yukihisa Ono
  • Method of treating a nitric oxide-associated disease with phenanthrene derivatives
    Patent number: 5654343
    Abstract: This invention provides a nitric oxide synthesis inhibitor composition comprising, as an active ingredient, at least one member of the group consisting of various phenanthrene derivatives, typically represented by the following general formula (1), and salts thereof. ##STR1## The nitric oxide synthesis inhibitor composition of this invention is useful for the prophylaxis and therapy of nitric oxide-associated diseases such as endotoxin shock.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: August 5, 1997
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Hideki Moritoki, Yoshihisa Takaishi, Masakazu Adachi, Yukihisa Ono
  • Phenanthrene derivatives
    Patent number: 5192817
    Abstract: Novel phenanthrene derivatives represented by the general formula (1), ##STR1## wherein the group of the formula ##STR2## is a group of the formula ##STR3## (wherein R.sup.1 is a hydrogen atom or a lower alkyl group), a group of the formula ##STR4## (wherein R.sup.2 is a hydrogen atom or a lower alkanoyl group) or a group of the formula ##STR5## (wherein R.sup.2 is the same as defined above), and salts thereof, and other compounds derived therefrom and salts thereof; processes for preparing the same; and interleukin-1 (IL-1) inhibitors containing the abovementioned novel phenanthrene derivatives as to the active ingredient(s).
    Type: Grant
    Filed: November 5, 1991
    Date of Patent: March 9, 1993
    Assignees: Otsuka Pharmaceutical Co., Ltd., Otsuka Pharmaceutical Factory, Inc.
    Inventors: Yoshihisa Takaishi, Kiyoto Goto, Takuji Uesako, Toshiko Kuwahara, Masaaki Takai, Yukihisa Ono, Yoshihiro Taniguchi, Sachiko Manabe, Takahiro Asakuni