Patents by Inventor Yukikazu Natori

Yukikazu Natori has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230295624
    Abstract: RNA molecules for RNA interference to target a mutant allele with a point mutation, wherein the molecule has a nucleotide sequence complementary to a nucleotide sequence of a coding region of the mutant allele; and when counted from the base at the 5?-end in the nucleotide sequence complementary to the sequence of the mutant allele: a base at position 5 or 6 is mismatched with a base in the mutant allele; a base at position 10 or 11 is at the position of the point mutation and is identical to the base at the position of the point mutation in the mutant allele; the group at the 2?-position of the pentose in the ribonucleotide at position 8 is modified with OCH3, halogen, or LNA; and the group at the 2?-position of the pentose in the ribonucleotide at position 7 is not modified with any of OCH3, halogen, and LNA.
    Type: Application
    Filed: January 17, 2022
    Publication date: September 21, 2023
    Applicant: THE UNIVERSITY OF TOKYO
    Inventors: Kumiko UI-TEI, Yoshiaki KOBAYASHI, Kaoru SAIGO, Yukikazu NATORI
  • Publication number: 20220411800
    Abstract: The present invention is directed to provide novel RNA molecules, chimeric NA molecules, double-stranded RNA molecules, and double-stranded chimeric NA molecules. Specifically, an embodiment of the present invention is an RNA molecule for RNA interference to target a mutant allele with a point mutation, in which (1) the molecule has a nucleotide sequence complementary to a nucleotide sequence of a coding region of the mutant allele; and (2) when counted from the base at the 5?-end in a nucleotide sequence complementary to a nucleotide sequence of the mutant allele, (2-1) a base at position 5 or 6 is mismatched to a base in the mutant allele; (2-2) a position 10 or 11 corresponds to the position of the point mutation; and (2-3) a group at the 2?-position of a pentose at positions 6-8 or positions 7 and 8 is modified with, e.g., OCH3. In this RNA molecule, one or more ribonucleotides may be replaced by, e.g., a deoxyribonucleotide. The molecule may form a double-stranded RNA with a complementary strand.
    Type: Application
    Filed: July 16, 2020
    Publication date: December 29, 2022
    Applicants: The University of Tokyo, The University of Tokyo
    Inventors: Kumiko UI-TEI, Yoshiaki KOBAYASHI, Kaoru SAIGO, Yukikazu NATORI, Atsushi SATO, Yoshimasa ASANO
  • Publication number: 20110054005
    Abstract: The present invention provides a polynucleotide that not only has a high RNA interference effect on its target gene, but also has a very small risk of causing RNA interference against a gene unrelated to the target gene. A sequence segment conforming to the following rules (a) to (d) is searched from the base sequences of a target gene for RNA interference and, based on the search results, a polynucleotide capable of causing RNAi is designed, synthesized, etc.: (a) The 3? end base is adenine, thymine, or uracil, (b) The 5? end base is guanine or cytosine, (c) A 7-base sequence from the 3? end is rich in one or more types of bases selected from the group consisting of adenine, thymine, and uracil, and (d) The number of bases is within a range that allows RNA interference to occur without causing cytotoxicity.
    Type: Application
    Filed: May 11, 2010
    Publication date: March 3, 2011
    Inventors: Yuki Naito, Masato Fujino, Shinobu Oguchi, Yukikazu Natori
  • Publication number: 20080113351
    Abstract: The present invention provides a polynucleotide that not only has a high RNA interference effect on its target gene, but also has a very small risk of causing RNA interference against a gene unrelated to the target gene. A sequence segment conforming to the following rules (a) to (d) is searched from the base sequences of a target gene for RNA interference and, based on the search results, a polynucleotide capable of causing RNAi is designed, synthesized, etc.: (a) The 3? end base is adenine, thymine, or uracil, (b) The 5? end base is guanine or cytosine, (c) A 7-base sequence from the 3? end is rich in one or more types of bases selected from the group consisting of adenine, thymine, and uracil, and (d) The number of bases is within a range that allows RNA interference to occur without causing cytotoxicity.
    Type: Application
    Filed: November 13, 2006
    Publication date: May 15, 2008
    Applicant: alphaGEN Co., Ltd.
    Inventors: Yuki Naito, Masato Fujino, Shinobu Oguchi, Yukikazu Natori
  • Patent number: 6111152
    Abstract: A method for separating vinyl chloride, which comprises cooling a cracked gas obtained by cracking 1,2-dichloroethane by a thermal cracking furnace, firstly in a heat exchanger, then further cooling it in a quenching tower and then distilling it, wherein the cracked gas is cooled in the heat exchanger to at least 350.degree. C., the quenching tower is controlled so that from 80 to 98 wt % of the cracked gas introduced is withdrawn as an overhead product and the rest of from 20 to 2 wt % of the cracked gas is withdrawn as a bottom effluent, and they are respectively sent to the subsequent steps, and formed coke is discharged together with the bottom effluent.
    Type: Grant
    Filed: May 17, 1999
    Date of Patent: August 29, 2000
    Assignee: Mitsubishi Chemical Corporation
    Inventors: Yukikazu Natori, Shinji Yamamoto, Kazutoshi Itoyama, Tetsuhiro Yamauchi