Abstract: Wound bed preparation in a skin wound area can be carried out by using a hydrogel sheet, wherein the hydrogel sheet is prepared by spreading a hydrogel containing a water-soluble polymer, glycerin, and water on a two-layered laminated film consisting of a polyurethane film and a hydrophobic fiber and the moisture permeability of the hydrogel sheet is 200-2000 (g/m2/24 h).

Abstract: External preparations for treatment of painful skin wound having an analgesic activity which comprises acetylsalicylic acid or its pharmacologically acceptable salt as an active ingredient.

Abstract: Wound bed preparation in a skin wound area can be carried out by using a hydrogel sheet, wherein the hydrogel sheet is prepared by spreading a hydrogel containing a water-soluble polymer, glycerin, and water on a two-layered laminated film consisting of a polyurethane film and a hydrophobic fiber and the moisture permeability of the hydrogel sheet is 200-2000 (g/m2/24 h).

Abstract: An apparatus and a method for simulatively measuring an environment in a microspace between human skin and a wound dressing. The simulative environment-measuring apparatus includes a constant temperature-and-humidity chamber (14); a heat exchanger (12) disposed in the chamber; a constant temperature water bath (10) and a pump (11) for supplying warm water to the heat exchanger; and a container (1) set on the heat exchanger. The container holds a water retentive member (2) therein, and is covered with a water vapor diffusion-controlling member (4). A microspace (6) formed between the water vapor diffusion-controlling member and a wound dressing (5) is a simulatively reproduced space between human skin and the wound dressing. A thin temperature-and-humidity sensor (7) is set in the microspace to measure temperature and humidity. When plural containers are used, the environments of plural wound dressings can be measured at once.

Abstract: Disclosed is a water-based adhesive skin patch which has excellent storage stability, can achieve excellent accumulation of butenafine hydrochloride contained therein on a patched area such as the skin and a nail, and has a high therapeutic effect. Specifically disclosed is a water-based adhesive skin patch containing butenafine hydrochloride, which is characterized by containing butenafine hydrochloride, glycol salicylate and propylene glycol in a water-containing gel ointment. Specifically, butenafine hydrochloride is dissolved in a mixed solution of glycol salicylate and propylene glycol, and the resulting solution is dispersed in a water-containing gel. Particularly, the mixing ratio of glycol salicylate to propylene glycol is 1:2 to 1:30.

Abstract: An external preparation containing acetylsalicylic acid or its pharmaceutically acceptable salt as an active ingredient for treating anal diseases having therapeutic activity on hemorrhoids (internal hemorrhoid, external hemorrhoid), hemorrhoidal disease owing to anal fissure and other anal diseases together with activity on pain and pruritus.

Abstract: Disclosed is a water-based adhesive skin patch which has excellent storage stability, can achieve excellent accumulation of butenafine hydrochloride contained therein on a patched area such as the skin and a nail, and has a high therapeutic effect. Specifically disclosed is a water-based adhesive skin patch containing butenafine hydrochloride, which is characterized by containing butenafine hydrochloride, glycol salicylate and propylene glycol in a water-containing gel ointment. Specifically, butenafine hydrochloride is dissolved in a mixed solution of glycol salicylate and propylene glycol, and the resulting solution is dispersed in a water-containing gel. Particularly, the mixing ratio of glycol salicylate to propylene glycol is 1:2 to 1:30.

Abstract: There are provided an apparatus and a method for simulatively measuring an environment in a microspace between a human skin and a wound dressing. The simulative environment-measuring apparatus comprises a constant temperature-and-humidity chamber 14 for controlling an external environment; a heat exchanger 12 disposed in the chamber 14; a constant temperature water bath 10 and a pump 11 for supplying warm water to the heat exchanger; and a container 1 which is set on the heat exchanger 12 and is easily detachable therefrom. The container 1 holds a water retentive member 2 therein, and is covered at its upper opening with a water vapor diffusion-controlling member 4. A microspace 6 formed between the water vapor diffusion-controlling member 4 and a wound dressing 5 placed on the member 4 is a simulatively reproduced space between a human skin and the wound dressing 5. A thin temperature-and-humidity sensor 7 is set in this microspace 6 to measure temperature and humidity with time.

Abstract: External preparations for treatment of painful skin wound having an analgesic activity which comprises acetylsalicylic acid or its pharmacologically acceptable salt as an active ingredient.

Abstract: An external preparation containing acetylsalicylic acid or a pharmacologically acceptable salt thereof as an active ingredient, which is used for treatment of vesicle, sore or ulcer of skin or mucosa caused by a viral infection.

Abstract: A neo-vascularization promoter containing acetylsalicylic acid or its pharmaceutically acceptable salt as an active ingredient.

Abstract: An external preparation containing acetylsalicylic acid or its pharmaceutically acceptable salt as an active ingredient for treating anal diseases having therapeutic activity on hemorrhoids (internal hemorrhoid, external hemorrhoid), hemorrhoidal disease owing to anal fissure and other anal diseases together with activity on pain and pruritus.

Abstract: An external preparation which contains acetylsalicylic acid or its salt as an active ingredient and has an effect of inhibiting keloid and/or hypertrophic scar formation as well as an analgesic and antipruritic effect.

Abstract: External preparations for treating pruritus containing Aspirin as an active ingredient, which exert an excellent therapeutic effects on pruritus with less side effects.

Abstract: External preparations for allergic dermatitis containing Aspirin alone as the active ingredient, which exert an excellent therapeutic effects on allergic dermatitis with lower side effects; and a method for treating allergic dermatitis by using these agents for external use.

Abstract: The present invention relates to an improved intravaginal preparation containing a physiologically active peptide, which comprises a physiologically active peptide, a sucrose fatty acid ester and an organic acid with a pharmaceutically acceptable carrier or diluent, by which the physiologically active peptide can be absorbed safely and efficiently.

Abstract: A pharmaceutical composition comprising a physiologically active polypeptide, an absorption promoting agent consisting of a combination of an organic acid and a fatty acid sucrose ester in admixture with a pharmaceutically acceptable carrier or diluent, which is suitable for oral administration and for application to the oral cavity, by which the polypeptide can sufficiently be absorbed through the intestinal tract or the mucous membrane in the oral cavity and exhibit the physiological activities without being suffered from enzymolysis.

Abstract: The present invention relates to an improved intravaginal preparation containing a physiologically active peptide, which comprises a physiologically active peptide, a sucrose fatty acid ester and an organic acid with a pharmaceutically acceptable carrier or diluent, by which the physiologically active peptide can be absorbed safely and efficiently.

Abstract: An oral pharmaceutical preparation of a type released at infragastrointestinal tract was successfully prepared, wherein a solid organic acid dissolvable, in the form of a solution, of chitosan and a solid pharmaceutical preparation including a principal agent are filled in a hard capsule composed of the base principally comprising chitosan and an enteric coating is formed on the surface of the hard capsule, characterized in that a desirable releasing time can be arranged, with no pH dependency, via water permeability derived from the porosity of chitosan of the capsule preparation.