Abstract: An object is to provide a technique that can enhance the binding properties of a single-stranded polynucleotide comprising a palindromic structure comprising an acyclic polynucleotide structural unit to target polynucleotides, such as miRNA, while suppressing self-duplex formation of the single-stranded polynucleotide. This object is achieved by a single-stranded polynucleotide comprising a palindromic structure comprising an acyclic polynucleotide structural unit, wherein adenine in the palindromic structure is replaced by diaminopurine, and thymine at a position complementary to the adenine is replaced by a thiouracil derivative.

Abstract: The present invention provides an oil-in-water emulsified composition comprising fatty acid soap, the following ingredients (2)-(5) and (6) water. (2) Polyethylene glycol having an average molecular weight of 2000-25000 in the amount of 0.3-4.0 wt % of the composition, (3) One, two, or more of nonionic surfactants having a HLB of 10-17 in the amount of 0.1-5.0 wt %, (4) one, two, or more of nonionic surfactants having a HLB of 2-10 in the amount of 0.1-5.0 wt % of the composition, and (5) an oil ingredient comprising a solid or semisolid oil ingredient in the amount of 40-70 wt % of the composition. The object of the present invention is to provide an oil-in-water emulsified composition primarily or secondarily aiming at removing dirt that exhibits no stickiness, superior stability, and richness.

Abstract: A humic substance dispersion fluid is obtainable by at least milling at least one of a humic substance and a humic substance derivative.

Abstract: The present invention provides an external preparation for skin comprising antibacterial zeolite and a nonvolatile liquid oil component that comprises a nonionic surfactant having a HLB of 6-8 that has a polyoxyethylene chain. The object of the present invention is to provide an external preparation for skin, particularly a deodorant cosmetic, that enables more effective removal of its stain on clothing by washing.

Abstract: The present invention provides an oil-in-water emulsified composition comprising fatty acid soap, the following ingredients (2)-(5) and (6) water. (2) Polyethylene glycol having an average molecular weight of 2000-25000 in the amount of 0.3-4.0 wt % of the composition, (3) One, two, or more of nonionic surfactants having a HLB of 10-17 in the amount of 0.1-5.0 wt %, (4) one, two, or more of nonionic surfactants having a HLB of 2-10 in the amount of 0.1-5.0 wt % of the composition, and (5) an oil ingredient comprising a solid or semisolid oil ingredient in the amount of 40-70 wt % of the composition. The object of the present invention is to provide an oil-in-water emulsified composition primarily or secondarily aiming at removing dirt that exhibits no stickiness, superior stability, and richness.

Abstract: A skin treatment composition comprising anti-bacterial zeolite and trisalt ethylenediaminehydroxyethyl triacetate. A skin treatment composition comprising anti-bacterial zeolite and alum and/or dried alum. A skin treatment composition comprising anti-bacterial zeolite and polyoxyethylene polyoxypropylene 2-decyltetradecyl ether. The object is to provide a skin treatment composition containing anti-bacterial zeolite that exhibits the effect of preventing discoloration of the skin treatment compositions and/or reducing the degree of discoloration. Another object is to provide a skin treatment composition that is superior in terms of formulation stability and tactile sensation during use. Yet another object is to provide a skin treatment composition having the effect of preventing the skin treatment composition from staining clothing and/or reducing the degree of such staining.