Patents by Inventor Yukiko Koyama

Yukiko Koyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant mammal cells, method of producing thereof, and method of producing proteins of interest
    Patent number: 8071332
    Abstract: The present invention relates to a method of expressing an objective protein at a high level and stably as well as for a long period even in the absence of a selection drug with a recombinant mammal cell. More particularly, the present invention relates to a method of producing an objective protein by providing a recombinant mammal cell having multiple copies of the exogenous objective protein gene expression unit integrated into a hypoxanthine-phosphoribosyl transferase enzyme (hprt) gene locus and culturing said cell.
    Type: Grant
    Filed: August 8, 2008
    Date of Patent: December 6, 2011
    Assignee: Toto Ltd.
    Inventors: Toshiaki Banzai, Yukiko Koyama, Shuji Sonezaki
  • Recombinant mammal cells, method of producing thereof, and method of producing proteins of interest
    Publication number: 20090117615
    Abstract: The present invention relates to a method of expressing an objective protein at a high level and stably as well as for a long period even in the absence of a selection drug with a recombinant mammal cell. More particularly, the present invention relates to a method of producing an objective protein by providing a recombinant mammal cell having multiple copies of the exogenous objective protein gene expression unit integrated into a hypoxanthine-phosphoribosyl transferase enzyme (hprt) gene locus and culturing said cell.
    Type: Application
    Filed: August 8, 2008
    Publication date: May 7, 2009
    Inventors: Toshiaki Banzai, Yukiko Koyama, Shuji Sonezaki