Patents by Inventor Yukiko Sekiguchi

Yukiko Sekiguchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic agent for glycogen storage disease type IA
    Patent number: 11958878
    Abstract: The present invention establishes a molecular therapy for glycogen storage disease type Ia. The present invention provides an oligonucleotide of 15-30 bases comprising a nucleotide sequence complementary to die cDNA of G6PC gene with c.648G>T mutation, wherein the oligonucleotide comprises a sequence complementary to a region comprising any site between the 82nd to the 92nd nucleotide from the 5? end of exon 5 of the G6PC gene with c.648C>T mutation, a pharmacologically acceptable salt or solvate thereof. Also provided is a pharmaceutical drug comprising the oligonucleotide, a pharmacologically acceptable salt or solvate thereof (e.g., therapeutic drug for glycogen storage disease type Ia).
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: April 16, 2024
    Assignees: Daiichi Sankyo Company, Limited, Kobe Gakuin Educational Foundation
    Inventors: Makoto Koizumi, Yoshiyuki Onishi, Takeshi Masuda, Mitsuhiro Iwamoto, Yukiko Sekiguchi, Kentaro Ito, Shinnosuke Tsuji, Masafumi Matsuo
  • CONJUGATE OF GalNAc-OLIGONUCLEOTIDE FOR DELIVERY TO LIVER AND MANUFACTURING METHOD THEREOF
    Publication number: 20220378920
    Abstract: The present invention provides a conjugate of an oligonucleotide having a nucleic acid sequence expected to have a pharmacological effect in hepatic parenchymal cells with a biantennary GalNAc unit, or a pharmaceutically acceptable salt thereof, and a medicament or the like containing the same as an active component.
    Type: Application
    Filed: September 9, 2020
    Publication date: December 1, 2022
    Applicant: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Makoto Koizumi, Mitsuhiro Iwamoto, Yukiko Sekiguchi, Kentaro Ito
  • HANP-Fc-containing molecular conjugate
    Patent number: 11008392
    Abstract: The present invention provides a conjugate comprising a hANP peptide bonded via a polyethylene glycol linker to a glycan attached to Asn297 of a Fc-containing molecule (N297 glycan), or a pharmaceutically acceptable salt thereof, a medicament comprising the same as an active ingredient, a method for producing the same, etc.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: May 18, 2021
    Assignee: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Mitsuhiro Iwamoto, Shohei Oishi, Yukiko Sekiguchi, Hiroyuki Chaya, Ryuki Miyauchi, Takeshi Honda
  • Endos mutant enzyme
    Patent number: 11001819
    Abstract: The present invention provides an EndoS mutant enzyme having an amino acid sequence of EndoS D233Q and further having a particular additional mutation and exhibiting a reduced hydrolysis activity, in comparison with the activity of EndoS D233Q, to an N-linked sugar chain (N297-linked sugar chain) linked to Asn at position 297 in IgG and a gene encoding the same.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: May 11, 2021
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Yoshirou Kawaguchi, Kensuke Nakamura, Yukiko Sekiguchi, Mitsuhiro Iwamoto
  • THERAPEUTIC AGENT FOR GLYCOGEN STORAGE DISEASE TYPE IA
    Publication number: 20200407394
    Abstract: The present invention establishes a molecular therapy for glycogen storage disease type Ia. The present invention provides an oligonucleotide of 15-30 bases comprising a nucleotide sequence complementary to the cDNA of G6PC gene with c.648G>T mutation, wherein the oligonucleotide comprises a sequence complementary to a region comprising any site between the 82nd to the 92nd nucleotide from the 5? end of exon 5 of the G6PC gene with c.648G>T mutation, a pharmacologically acceptable salt or solvate thereof. Also provided is a pharmaceutical drug comprising the oligonucleotide, a pharmacologically acceptable salt or solvate thereof (e.g., therapeutic drug for glycogen storage disease type Ia).
    Type: Application
    Filed: March 5, 2019
    Publication date: December 31, 2020
    Applicants: DAIICHI SANKYO COMPANY, LIMITED, KOBE GAKUIN EDUCATIONAL FOUNDATION
    Inventors: Makoto KOIZUMI, Yoshiyuki ONISHI, Takeshi MASUDA, Mitsuhiro IWAMOTO, Yukiko SEKIGUCHI, Kentaro ITO, Shinnosuke TSUJI, Masafumi MATSUO
  • HANP-FC-CONTAINING MOLECULAR CONJUGATE
    Publication number: 20190169293
    Abstract: The present invention provides a conjugate comprising a hANP peptide bonded via a polyethylene glycol linker to a glycan attached to Asn297 of a Fc-containing molecule (N297 glycan), or a pharmaceutically acceptable salt thereof, a medicament comprising the same as an active ingredient, a method for producing the same, etc.
    Type: Application
    Filed: June 30, 2017
    Publication date: June 6, 2019
    Applicant: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Mitsuhiro IWAMOTO, Shohei OISHI, Yukiko SEKIGUCHI, Hiroyuki CHAYA, Ryuki MIYAUCHI, Takeshi HONDA
  • NOVEL ENDOS MUTANT ENZYME
    Publication number: 20180208915
    Abstract: The present invention provides an EndoS mutant enzyme having an amino acid sequence of EndoS D233Q and further having a particular additional mutation and exhibiting a reduced hydrolysis activity, in comparison with the activity of EndoS D233Q, to an N-linked sugar chain (N297-linked sugar chain) linked to Asn at position 297 in IgG and a gene encoding the same.
    Type: Application
    Filed: July 15, 2016
    Publication date: July 26, 2018
    Applicant: Daiichi Sankyo Company, Limited
    Inventors: Yoshirou Kawaguchi, Kensuke Nakamura, Yukiko Sekiguchi, Mitsuhiro Iwamoto
  • Heterocyclic compound
    Patent number: 7687491
    Abstract: A compound having immunosuppressive activity with low toxicity or a pharmacological salt thereof.
    Type: Grant
    Filed: October 19, 2007
    Date of Patent: March 30, 2010
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Takahide Nishi, Tsuyoshi Nakamura, Yukiko Sekiguchi, Yumiko Mizuno, Takaichi Shimozato, Futoshi Nara
  • Heterocyclic compound
    Publication number: 20080113961
    Abstract: A compound having immunosuppressive activity with low toxicity or a pharmacological salt thereof.
    Type: Application
    Filed: October 19, 2007
    Publication date: May 15, 2008
    Applicant: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Takahide Nishi, Tsuyoshi Nakamura, Yukiko Sekiguchi, Yumiko Mizuno, Takaichi Shimozato, Futoshi Nara