Abstract: An antibody or antigen-binding fragment thereof is disclosed. The antibody or antigen-binding fragment thereof binds to HER2 expressed on a cancer cell or a fragment of the HER2. A HER2-targeting agent containing any of the antibody or antigen-binding fragment thereof, and a pharmaceutical composition containing the HER2-targeting agent are disclosed.

Abstract: An antibody that binds to HER2 expressed on a cancer cell or a fragment of the HER2, or an antigen binding fragment thereof are disclosed. Uses of the antibody or antigen binding fragment thereof are disclosed. The antibody or antigen binding fragment thereof is useful to target a HER2 expressing cancer cells. A-pharmaceutical composition containing the antibody or antigen binding fragment thereof is also disclosed.

Abstract: A management server executes a process including: a step of acquiring operation information when an execution condition is established; a step of setting a traveling route; a step of calculating an accumulated amount of load when there is a vehicle set on the forwarding route; a step of setting the details of canceling the travel restriction according to the accumulated amount of the load of the vehicle on the forwarding route when there is a vehicle in a high accumulated state; a step of setting cancellation of travel restrictions for vehicles on the forwarding route when there is no vehicle in a high accumulation state; and a step of transmitting the travel plan information.

Abstract: A management server executes a process including: a step of acquiring operation information) when an execution condition is established; a step of setting a traveling route; a step of setting a first usage fee as a fee, when there is a vehicle set on a forwarding route, and when the vehicle on the forwarding route is in a high load state; a step of setting a second usage fee that is higher than the first usage fee as the usage fee when the vehicle on the forwarding route is in a low load state; a step of setting a usage fee for the vehicle on a normal route; and a step of transmitting fee information to the vehicle.

Abstract: When a vehicle allocation request is made, a management server executes a process including: a step of acquiring operation information; a step of acquiring a traveling route of a vehicle allocation destination, and a step of calculating an accumulated amount of load; a step of setting a vehicle with a low accumulated amount as an allocated vehicle when the traveling route of the vehicle allocation destination has a high load; a step of setting a vehicle with a high accumulated amount as an allocated vehicle when the traveling route of the vehicle allocation destination is not a high load; and a step of transmitting the travel plan information.

Abstract: When a computer of an ADK determines that a condition for performing self-diagnosis processing is met, or when performance of self-diagnosis processing is notified from a VP even if the condition for performing self-diagnosis processing is not met, the computer performs processing including: a step of performing self-diagnosis processing; a step of notifying the performance of the self-diagnosis processing to the VP; and a step of transmitting a result of diagnosis obtained through the self-diagnosis processing by the ADK to a central ECU when the self-diagnosis processing is completed.

Abstract: The present disclosure enhances security of a service of storing baggage in a locker loaded in a vehicle. An information processing apparatus of the present disclosure includes a controller configured to, for baggage stored in a locker loaded in a vehicle, make a notification that confirms unlocking of the locker to a user terminal associated with the baggage, with a locked state of the locker being maintained, when a predetermined event related to unlocking of the locker is detected before a first date and time set in advance. The controller decides whether or not to take out the baggage from the locker based on an answer to the notification from the user terminal.

Abstract: An information processing device includes a control unit configured to send first information including a first date and time, to a user terminal, at a predetermined timing before the first date and time, the first date and time being a date and time at which baggage deposited in a movable locker is planned to be taken out, the movable locker being mounted on a vehicle, the user terminal being used by a user that has deposited the baggage in the locker. The predetermined timing is a timing that is earlier than the first date and time by a first time length. The control unit sets the first time length such that the first time length is longer as the distance between a first place and the position of the user terminal is longer, the first place being a place at which the baggage is planned to be taken out.

Abstract: The present invention provides a cancer cell-specific anti-podoplanin antibody or an antigen-binding fragment thereof having an epitope in a Thr85-containing region of an amino acid sequence of human podoplanin represented by SEQ ID NO: 1, the Thr85 having a sialylated O-glycan added thereto.

Abstract: The present invention provides a cancer microenvironment-targeting anti-podocalyxin antibody or antigen binding fragment thereof.

Abstract: The present invention provides a cancer cell-specific anti-podoplanin antibody or an antigen-binding fragment thereof having an epitope in a Thr85-containing region of an amino acid sequence of human podoplanin represented by SEQ ID NO: 1, the Thr85 having a sialylated O-glycan added thereto.

Abstract: The present invention provides a method for producing an antibody against podocalyxin expressed specifically in cancer cells. The method includes a step of introducing a nucleic acid encoding all or a portion of podocalyxin into cells expressing a cancer cell-specific sugar chain structure to cause cancer cell-specific podocalyxin or a portion thereof to be expressed therein, a step of immunizing a non-human mammal with the cancer cell-specific podocalyxin or portion thereof to obtain antibodies, and a step of purifying the antibodies by primary screening using purified cancer cell-specific podocalyxin or a portion thereof.

Abstract: The present invention provides a cancer microenvironment-targeting anti-podocalyxin antibody or antigen binding fragment thereof.

Abstract: Object of the present invention is to provide various anti-podoplanin antibodies useful as a drug or reagent. The present invention provides an anti-podoplanin antibody or antigen-binding fragment thereof, each having an epitope in any of the following regions in the amino acid sequence of podoplanin represented by SEQ ID NO: 1: (i) from position 56 to position 80, (ii) from position 81 to position 103, (iii) from position 81 to position 88, and (iv) from position 25 to position 57.

Abstract: A current collector for a secondary battery (1) of the present invention includes a resin layer (2) having electrical conductivity, and an ion barrier layer (3) provided on the surface of the resin layer (2). The ion barrier layer (3) contains ion trapping particles (6) in which metal compounds (5) are provided on the surfaces of metal containing particles (4). The ion trapping particles (6) are continuously provided from an interface (7) between the resin layer (2) and the ion barrier layer (3) toward a surface (3a) of the ion barrier layer (3). Thus, the ion barrier layer (3) prevents from the entry of ions, so that the ion adsorption in the current collector (1) can be decreased.

Abstract: The present invention provides a method for producing an antibody against podocalyxin expressed specifically in cancer cells. The method includes a step of introducing a nucleic acid encoding all or a portion of podocalyxin into cells expressing a cancer cell-specific sugar chain structure to cause cancer cell-specific podocalyxin or a portion thereof to be expressed therein, a step of immunizing a non-human mammal with the cancer cell-specific podocalyxin or portion thereof to obtain antibodies, and a step of purifying the antibodies by primary screening using purified cancer cell-specific podocalyxin or a portion thereof.

Abstract: A V2X system includes an electrical power distribution system configured to draw electrical power from a grid, support the supply of the drawn electrical power to one or more primary electrical systems and support the exchange of electrical power with a battery bank including at least one rechargeable vehicle battery. A controller manages the exchange of electrical power between the electrical power distribution system and the battery bank by identifying a change rate in electrical power drawn by the electrical power distribution system from the grid, selecting an amount of electrical power for the electrical power distribution system to exchange with the battery bank based on the change rate, and signaling for the exchange of the selected amount of electrical power.

Abstract: Object of the present invention is to provide various anti-podoplanin antibodies useful as a drug or reagent. The present invention provides an anti-podoplanin antibody or antigen-binding fragment thereof, each having an epitope in any of the following regions in the amino acid sequence of podoplanin represented by SEQ ID NO: 1: (i) from position 56 to position 80, (ii) from position 81 to position 103, (iii) from position 81 to position 88, and (iv) from position 25 to position 57.

Abstract: In a device for controlling an assembled battery provided with a plurality of single batteries, the device includes a capacity adjustment section for adjusting a capacity such that voltages of the single batteries are equalized at a targeted voltage, an internal state detection section for detecting terminal voltages or SOC of the single batteries and for detecting, based on the detected terminal voltages/SOC, a voltage/SOC difference among the single batteries as voltage-difference/SOC-difference data, and a time-series data storage for storing the voltage-difference/SOC-difference data in time-series. Also provided is a prediction section for more appropriately predicting time when the assembled battery becomes an abnormal state, based on a time-dependent change in the voltage-difference/SOC-difference data detected in a voltage/SOC region different from the targeted voltage by a predetermined voltage, among the stored time-series voltage-difference/SOC-difference data.

Abstract: A V2X system includes an electrical power distribution system configured to draw electrical power from a grid, support the supply of the drawn electrical power to one or more primary electrical systems and support the exchange of electrical power with a battery bank including at least one rechargeable vehicle battery. A controller manages the exchange of electrical power between the electrical power distribution system and the battery bank by identifying a change rate in electrical power drawn by the electrical power distribution system from the grid, selecting an amount of electrical power for the electrical power distribution system to exchange with the battery bank based on the change rate, and signaling for the exchange of the selected amount of electrical power.