Abstract: An air conditioner selection system is a system for selecting an air conditioner including an indoor unit. The air conditioner selection system is provided with a floor area acquisition section, an allowable refrigerant amount acquisition section, and an air conditioner selection section. The floor area acquisition section acquires a floor area of a room where the indoor unit is to be installed. The allowable refrigerant amount acquisition section acquires an allowable refrigerant amount of a refrigerant allowed to remain in the room at least based on the floor area acquired by the floor area acquisition section. The air conditioner selection section selects the air conditioner including the indoor unit installable in the room at least based on the allowable refrigerant amount acquired by the allowable refrigerant amount acquisition section.

Abstract: An air conditioning management system includes an air conditioner, a communication control device configured to acquire and transmit operation data of the air conditioner, and an information management device configured to receive the operation data transmitted from the communication control device via a network, in which the communication control device has a communication module configured to transmit the operation data by specified low power wireless communication, and a transmission control unit configured to select only a predetermined item from the operation data of a plurality of items acquired from the air conditioner and cause the communication module to transmit the predetermined item.

Abstract: The purpose of the present invention is to provide novel miR-143 derivatives described herein that can be used as oligonucleotide therapeutics.

Abstract: An air conditioner management system according to the present invention enables timely maintenance on an air conditioner installed in a region requiring predetermined maintenance. An air conditioner management system (100) includes a maintenance region information database (23a), an installation region information acquisition unit (12a), and a maintenance necessity determination unit (22c). The maintenance region information database (23a) stores maintenance region information about a region requiring predetermined maintenance on an air conditioner (50). The installation region information acquisition unit (12a) acquires air conditioner installation region information about a region where the air conditioner (50) is installed.

Abstract: An air conditioner selection system according to the present invention is capable of efficiently selecting an air conditioner that satisfies a safety standard requirement in a case where a refrigerant leaks. An air conditioner selection system (100) is a system for selecting an air conditioner (50) including an indoor unit (52). The air conditioner selection system (100) is provided with a floor area acquisition section (12a), an allowable refrigerant amount acquisition section (12b), and an air conditioner selection section (12c). The floor area acquisition section (12a) acquires a floor area of a room (3) where the indoor unit (52) is to be installed. The allowable refrigerant amount acquisition section (12b) acquires an allowable refrigerant amount of a refrigerant allowed to remain in the room (3) at least based on the floor area acquired by the floor area acquisition section (12a).

Abstract: The oligonucleotide derivative of the present invention is represented by Formula (1). This derivative is considered to be introduced into cells by binding of its amino sugar chain moiety to a ligand on cell surfaces, and have selective drug delivery function. The oligonucleotide derivative can be easily synthesized and introduced into cells without using a lipofection reagent. wherein A and B are independently modified or unmodified oligonucleotides whose total chain length is 3 or more, and A and B do not contain hydroxyl groups at 3? and 5? ends of the oligonucleotide; S represents a sugar substituent, a peptide chain, or a tocopherol-binding group; and an alkyl group may be bound instead of hydrogen bound to a benzene ring.

Abstract: The purpose of the present invention is to provide novel miR-143 derivatives described herein that can be used as oligonucleotide therapeutics.

Abstract: Provided is an RNA interference agent, with which a suppression effect on the off-target effect can be obtained with a simple system. The disclosures relate to an RNA interference agent provided with a single-stranded oligonucleotide passenger strand having one or two or more PAZ domain low-affinity units at the 3?-end.

Abstract: The oligonucleotide derivative of the present invention is represented by Formula (1). This derivative is considered to be introduced into cells by binding of its amino sugar chain moiety to a ligand on cell surfaces, and have selective drug delivery function. The oligonucleotide derivative can be easily synthesized and introduced into cells without using a lipofection reagent. wherein—A and B are independently modified or unmodified oligonucleotides whose total chain length is 3 or more, and A and B do not contain hydroxyl groups at 3? and 5? ends of the oligonucleotide; S represents a sugar substituent, a peptide chain, or a tocopherol-binding group; and an alkyl group may be bound instead of hydrogen bound to a benzene ring.

Abstract: Provided is an RNA interference agent, with which a suppression effect on the off-target effect can be obtained with a simple system. The disclosures relate to an RNA interference agent provided with a single-stranded oligonucleotide passenger strand having one or two or more PAZ domain low-affinity units at the 3?-end.

Abstract: The present invention provides an oligonucleotide derivative that enables to easily synthesize an oligonucleotide derivative chemically modified at the 3?-end with two moieties each having a benzene or pyridine structure with a few steps, an aromatic compound serving as a precursor for preparing the modification carrier for synthesizing oligonucleotide derivative, and the oligonucleotide derivative and the oligonucleotide construct using the same, that is chemically modified at the 3?-end with two moieties each having a benzene or pyridine structure, and has good permeability through a cell membrane and excellent nuclease resistance. The modification carrier for synthesizing oligonucleotide derivative, comprising a unit and a carrier carrying the unit directly or via a linker, wherein the unit is represented by the formula (a): wherein, R1 to R6 each independently represent hydrogen or a substituent other than hydrogen; Z1 and Z2 each independently represent CH or nitrogen; and X represents oxygen or sulfur.

Abstract: Provided is a nucleoside derivative which has a high affinity for RNA. Use is made of a nucleoside derivative represented by either formula (1) or formula (2). (In formulae (1) and (2), Z represents a carbon atom or a nitrogen atom; R1 represents a hydrogen atom or a hydroxyl-protecting group; and R2 represents a hydrogen atom or a phosphodiester group).

Abstract: A labeling agent comprising a plurality of nucleotide derivative units represented by Formula (1) below: (where, Z represents a nitrogen atom or CH, Y represents an uncondensed aromatic hydrocarbon group or condensed polycyclic hydrocarbon group, X1 represents O, S or Se, and X2 represents SH (or S?), Se?, a C1-4 alkyl or a morpholino group).

Abstract: The present invention provides an oligonucleotide derivative that enables to easily synthesize an oligonucleotide derivative chemically modified at the 3?-end with two moieties each having a benzene or pyridine structure with a few steps, an aromatic compound serving as a precursor for preparing the modification carrier for synthesizing oligonucleotide derivative, and the oligonucleotide derivative and the oligonucleotide construct using the same, that is chemically modified at the 3?-end with two moieties each having a benzene or pyridine structure, and has good permeability through a cell membrane and excellent nuclease resistance. The modification carrier for synthesizing oligonucleotide derivative, comprising a unit and a carrier carrying the unit directly or via a linker, wherein the unit is represented by the formula (a): wherein, R1 to R6 each independently represent hydrogen or a substituent other than hydrogen; Z1 and Z2 each independently represent CH or nitrogen; and X represents oxygen or sulfur.

Abstract: The disclosures of the Specification provide an oligonucleotide derivative suited to practical use, as well as a fluorescent dye cluster and use therefor. The disclosures of the Specification use a labeling agent comprising a plurality of nucleotide derivative units represented by Formula (1) below: (where, Z represents a nitrogen atom or CH, Y represents an uncondensed aromatic hydrocarbon group or condensed polycyclic hydrocarbon group, X1 represents O, S or Se, and X2 represents SH (or S?), S or Se?, a CI-4 alkyl or a morpholino group.

Abstract: An air conditioner monitoring system includes: a plurality of air conditioners (10) each including a refrigerant circuit (11) for performing a vapor compression refrigeration cycle; a local controller (60) provided for each of sets of several ones of the air conditioners (10) for receiving data output by the each of sets of several ones of the air conditioners (10), and transmitting predetermined operation data; and a host controller (70) for receiving the operation data of the plurality of air conditioners (10) transmitted by the local controllers (60) through communication lines (53). The host controller (70) calculates air conditioning capability and power consumption of each of the air conditioners (10) in the each of sets of several ones of the air conditioners (10), and calculates energy utilization efficiency of each of the air conditioners (10).

Abstract: Provided is a nucleoside derivative which has a high affinity for RNA. Use is made of a nucleoside derivative represented by either formula (1) or formula (2). (In formulae (1) and (2), Z represents a carbon atom or a nitrogen atom; R1 represents a hydrogen atom or a hydroxyl-protecting group; and R2 represents a hydrogen atom or a phosphodiester group).

Abstract: The invention provides a 5?-amino-2?-fluoro-2?,5?-dideoxynucleoside compound represented by the formula [1]: wherein R1 represents a nucleic acid base which may have a protecting group; R2 represents a hydrogen atom or an amino protecting group; and R3 represents a hydrogen atom or a hydroxyl protecting group. The invention also provides a dideoxynucleoside-insoluble carrier bound substance and an oligonucleotide analogue involving the dideoxynucleoside compound.

Abstract: The present invention discloses a 5?-amino-2?-fluoro-2?,5?-dideoxynucleoside derivative represented by the following formula [1]: (wherein R1 represents a nucleic acid base which may have a protecting group; R2 represents a hydrogen atom or a protecting group of an amino group; R3 represents a hydrogen atom or a protecting group of a hydroxyl group); a dideoxynucleoside-insoluble carrier bound substance prepared by binding said dideoxynucleoside derivative to an insoluble carrier, and an oligonucleotide analogue into which said dideoxynucleoside derivative is introduced. The oligonucleotide analogue being introduced with a dideoxynucleoside derivative of the present invention has excellent thermal stability and also high binding affinity when duplex is formed. Also, it is anticipated that it has high resistance to nucleases.

Abstract: It is an object to provide a nucleoside analog that can produce an oligonucleotide analog in which the two properties of chemical and biological stability, and the ability to form double strands, are excellent, and an oligonucleotide analog that includes that nucleoside analog. This is achieved by a nucleoside analog or salt thereof represented by Formula (I) below, in which, in Formula (I), R1 is any group selected from the group consisting of the group of Formula (1), the group of Formula (2), the group of Formula (3), the group of Formula (4), the group of Formula (5), the group of Formula (6), the group of Formula (7), the group of Formula (8), and any of these groups whose functional group has been protected by a protecting group, and k, l, m, and n are each independently an integer from 1 to 10.