Patents by Inventor Yukio Nagasaki

Yukio Nagasaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240424011
    Abstract: A prodrug of an anticancer drug is used in combination therapy with radiotherapy. In the chemical formula (1), a moiety in which R1 and R2 bond to an N atom is a part of an anticancer drug having an amino group or an imino group with the amino group or the imino group removed, and the anticancer drug is selected from the group consisting of gemcitabine, niraparib, crizotinib, tabrafenib, vemurafenib, entinostat, cobimetinib, and palbociclib, ribociclib. Thereby, the side effects of the treatment, including radiotherapy, for malignant tumors are reduced or the treatment effect is enhanced.
    Type: Application
    Filed: December 14, 2022
    Publication date: December 26, 2024
    Applicant: UNIVERSITY OF TSUKUBA
    Inventors: Yutaka IKEDA, Yukio NAGASAKI
  • Publication number: 20240277642
    Abstract: Provided is a valproic acid derivative for improving disadvantages or defects accompanying when valproic acid itself or the like is used as a medicine. Provided is a block copolymer which is a polymerized product of valproic acid and comprises a poly(ethylene glycol) segment and a poly(vinyl valproate) segment.
    Type: Application
    Filed: May 23, 2022
    Publication date: August 22, 2024
    Applicant: UNIVERSITY OF TSUKUBA
    Inventors: Yukio NAGASAKI, Yutaka IKEDA, Yuya TAJIKA
  • Patent number: 12049543
    Abstract: A copolymer which includes hydrophilic and hydrophobic blocks, which can form nanoparticles in which a physiologically active substance can be efficiently packaged therein and which are stable under acidic conditions. The hydrophilic segment of the copolymer is composed of polyethylene glycol (PEG) and the hydrophobic segment is composed of polystyrene. The hydrophobic segment has a side chain, and the side chain has ends to which a cyclic nitroxide radical having a radical scavenging function and a trialkoxysilane are covalently bonded.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: July 30, 2024
    Assignee: CrestecBio Inc.
    Inventors: Yukio Nagasaki, Takuya Inagaki, Binh Long Vong
  • Publication number: 20240000829
    Abstract: An objective of the present invention is to provide a self-assembled polymer micelle-type ornithine donor, which has high bioavailability, low toxicity, and high therapeutic effectiveness, even when provided by oral administration. Another objective of the present invention is to provide a self-assembled polymer micelle-type ornithine donor which is effective in preventing or treating hepatic disorders. In order to achieve the above objectives, an acyl group is introduced into the primary amino group in the side chain of an ornithine unit in the poly(ornithine) segment of poly(ethylene glycol)-b-poly(ornithine), which spontaneously forms polymer micelles without polyion complex formation.
    Type: Application
    Filed: November 9, 2021
    Publication date: January 4, 2024
    Applicant: University of Tsukuba
    Inventors: Yukio NAGASAKI, Yaroslav LEE, Long Binh VONG, Yuta KODA, Yuanyuan DING
  • Publication number: 20220332876
    Abstract: [Object] To provide a derivative of a short chain fatty acid that can exhibit physiological functions inherent in the short chain fatty acid. [Solution] Provided is a block or graft copolymer including a hydrophobic segment of a repeat unit containing a short chain fatty acid ester that is hydrolyzable by esterase in vivo and a hydrophilic segment including a poly(ethylene glycol) chain. These copolymers are effective in the treatment or therapeutic treatment of various diseases or disorders, including cancer.
    Type: Application
    Filed: July 30, 2020
    Publication date: October 20, 2022
    Applicant: UNIVERSITY OF TSUKUBA
    Inventors: Yukio NAGASAKI, Babita SHASHNI, Binh Long VONG, Ryusaku OKADA, Yuya TAJIKA, Yaroslav LEE
  • Publication number: 20220125752
    Abstract: Incorporation of L-DOPA into a carrier in a form of a block copolymer (PEG-b-poly(3,4-hydroxy-protected L-DOPA)) significantly improves the retention of the agent in the blood, thus mitigating a shortcoming associated with L-DOPA in treating Parkinson's disease.
    Type: Application
    Filed: February 6, 2020
    Publication date: April 28, 2022
    Applicant: UNIVERSITY OF TSUKUBA
    Inventors: Yukio NAGASAKI, Yuna SATO, Long Binh VONG, Pennapa CHONPATHOMPIKUNLERT, Pilaiwanwadee HUTAMEKALIN, Reita TAKAHASHI
  • Publication number: 20190345293
    Abstract: A copolymer which includes hydrophilic and hydrophobic blocks, which can form nanoparticles in which a physiologically active substance can be efficiently packaged therein and which are stable under acidic conditions. The hydrophilic segment of the copolymer is composed of polyethylene glycol (PEG) and the hydrophobic segment is composed of polystyrene. The hydrophobic segment has a side chain, and the side chain has ends to which a cyclic nitroxide radical having a radical scavenging function and a trialkoxysilane are covalently bonded.
    Type: Application
    Filed: January 18, 2018
    Publication date: November 14, 2019
    Applicant: UNIVERSITY OF TSUKUBA
    Inventors: Yukio NAGASAKI, Takuya INAGAKI, Binh Long VONG
  • Patent number: 10398803
    Abstract: Provided is a coating agent which can be stably immobilized on metal surface, and which can give blood compatibility. Provided is a copolymer which is usable as the above-mentioned coating agent that comprises PEG segment and a segment which has a phosphoric acid residue (PO(—OH)2) and a cyclic nitroxideradical randomly as a side chain or a pendant group.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: September 3, 2019
    Assignee: UNIVERSITY OF TSUKUBA
    Inventors: Yukio Nagasaki, Yutaka Ikeda, Kouya Akasaka
  • Patent number: 10208152
    Abstract: A method for efficiently producing a poly(ethylene glycol)-b-poly(halomethylstyrene), a novel poly(ethylene glycol)-b-poly(halomethylstyrene) produced using the method, and a derivative thereof. The target novel copolymer can be provided by introducing a functional group, which enables reversible addition-fragmentation chain transfer (RAFT) polymerization, to the ? terminal of poly(ethylene glycol) and copolymerizing the resulting poly(ethylene glycol) with a halomethylstyrene.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: February 19, 2019
    Assignee: UNIVERSITY OF TSUKUBA
    Inventor: Yukio Nagasaki
  • Patent number: 10155009
    Abstract: An object of the present invention is to provide a composition that serves as an efficient arginine substrate for inducible NO synthase (iNOS) in tumor. The present invention provides a polyion complex (PIC) of PEG-b-poly(L-Arg) or poly(L-Arg)-b-PEG-b-poly(L-Arg) and a polyanionic polymer, and use thereof.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: December 18, 2018
    Assignee: GENERAL INCORPORATED ASSOCIATION TSUKUBA GLOBAL INNOVATION PROMOTION AGENCY
    Inventors: Yukio Nagasaki, Shinpei Kudo, Yuji Hiramatsu, Hiroaki Sakamoto, Quoc Thang Bui, Binh Long Vong
  • Publication number: 20180256782
    Abstract: Provided is a coating agent which can be stably immobilized on metal surface, and which can give blood compatibility. Provided is a copolymer which is usable as the above-mentioned coating agent that comprises PEG segment and a segment which has a phosphoric acid residue (PO(—OH)2) and a cyclic nitroxideradical randomly as a side chain or a pendant group.
    Type: Application
    Filed: November 29, 2016
    Publication date: September 13, 2018
    Applicant: UNIVERSITY OF TSUKUBA
    Inventors: Yukio NAGASAKI, Yutaka IKEDA, Kouya AKASAKA
  • Patent number: 9962469
    Abstract: [Problem] To provide a composition capable of effectively preventing adhesion. [Solution] An adhesion-preventing preparation comprising, as an active ingredient, a composition comprising an A-B-A triblock copolymer, in which A denotes a cationically chargeable polymer block and B denotes a water-soluble block that comprises a poly(ethylene glycol) (or poly(oxyethylene)) chain, and a polyanionic polymer.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: May 8, 2018
    Assignee: UNIVERSITY OF TSUKUBA
    Inventors: Yukio Nagasaki, Hiroyuki Nakagawa
  • Publication number: 20180085395
    Abstract: An object of the present invention is to provide a composition that serves as an efficient arginine substrate for inducible NO synthase (iNOS) in tumor. The present invention provides a polyion complex (PIC) of PEG-b-poly(L-Arg) or poly(L-Arg)-b-PEG-b-poly(L-Arg) and a polyanionic polymer, and use thereof.
    Type: Application
    Filed: April 15, 2016
    Publication date: March 29, 2018
    Applicant: GENERAL INCORPORATED ASSOCIATION TSUKUBA GLOBAL INNOVATION PROMOTION AGENCY
    Inventors: Yukio NAGASAKI, Shinpei KUDO, Yuji HIRAMATSU, Hiroaki SAKAMOTO, Quoc Thang BUI, Binh Long VONG
  • Patent number: 9918935
    Abstract: [Problem] To provide a physiologically active peptide-loaded stable composition for injection into living bodies. [Solution] A composition containing a triblock copolymer represented by formula (I), a polyanionic polymer and a physiologically active peptide: CNR-PEG-CNR??(I) in the formula, CNR moieties are each independently a polymer segment containing a repeating unit that contains, as a part of a pendant group, a cyclic nitroxide radical bonded to a main polymer chain via a linking group that contains at least one amino group, and PEG is a segment that contains poly(ethylene glycol).
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: March 20, 2018
    Assignee: UNIVERSITY OF TSUKUBA, A JAPANESE NATIONAL UNIVERSITY
    Inventors: Yukio Nagasaki, Junya Kaneko, Toru Yoshitomi, Shiro Ishii
  • Patent number: 9862992
    Abstract: A substrate surface on which either a substance to detect analyte or an analyte per se is immobilized, which surface is formed by a treatment of substrate surface with a liquid which contains uncrosslinked polymer based on polyethylene glycol chain segment, said treatment conducted either simultaneously with the immobilization of said substance or analyte or after said substance or analyte has been immobilized on said surface. The non-specific adsorption of impurity protein or the like which is co-existent in sample for assay is significantly restrained.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: January 9, 2018
    Assignee: JSR CORPORATION
    Inventors: Yukio Nagasaki, Tadahito Takahashi, Kazunori Kataoka, Fumiko Aboshi, Miki Kato, Tomoko Jomura, Hiroshi Kobayashi, Yoshinori Katsuyama, Masami Nakamae
  • Patent number: 9849186
    Abstract: Provided is a triblock copolymer represented by General Formula (I): CNR-PEG-CNR??(1) or a polycation thereof, wherein each CNR is independently a polymer segment having a repeating unit containing as part of a pendant group a cyclic nitroxide radical that binds to the polymer main chain via a linking group having at least one imino group or ether bond, and PEG is a segment containing poly(ethylene glycol).
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: December 26, 2017
    Assignee: UNIVERSITY OF TSUKUBA
    Inventors: Yukio Nagasaki, Min Ley Pua, Pennapa Chonpathompikunlert, Toru Yoshitomi
  • Publication number: 20170247491
    Abstract: [Problem] To provide a method for efficiently producing a poly(ethylene glycol)-b-poly(halomethylstyrene), a novel poly(ethylene glycol)-b-poly(halomethylstyrene) produced using the method, and a derivative thereof. [Solution] The target novel copolymer can be provided by introducing a functional group, which enables reversible addition-fragmentation chain transfer (RAFT) polymerization, to the ? terminal of poly(ethylene glycol) and copolymerizing the resulting poly(ethylene glycol) with a halomethylstyrene.
    Type: Application
    Filed: September 29, 2015
    Publication date: August 31, 2017
    Applicant: UNIVERSITY OF TSUKUBA
    Inventor: Yukio NAGASAKI
  • Patent number: 9655975
    Abstract: Provided is a prodrug of 2-nitro-1-imidazolepropionic acid and a therapeutically active organic compound having on the molecule an amino group, a cyclic amino group or a hydroxyl group, particularly a prodrug in which the therapeutically active organic compound is selected from among antitumor agents. The prodrug cleaves specifically under hypoxic conditions in vivo to exhibit the inherent therapeutic activity.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: May 23, 2017
    Assignee: UNIVERSITY OF TSUKUBA
    Inventors: Yukio Nagasaki, Yutaka Ikeda, Hikaru Hisano
  • Publication number: 20160346438
    Abstract: [Problem] To provide a composition capable of effectively preventing adhesion. [Solution] An adhesion-preventing preparation comprising, as an active ingredient, a composition comprising an A-B-A triblock copolymer, in which A denotes a cationically chargeable polymer block and B denotes a water-soluble block that comprises a poly(ethylene glycol) (or poly(oxyethylene)) chain, and a polyanionic polymer.
    Type: Application
    Filed: January 27, 2015
    Publication date: December 1, 2016
    Applicant: UNIVERSITY OF TSUKUBA
    Inventors: Yukio NAGASAKI, Hiroyuki NAKAGAWA
  • Publication number: 20160175247
    Abstract: [Problem] To provide a physiologically active peptide-loaded stable composition for injection into living bodies. [Solution] A composition containing a triblock copolymer represented by formula (I), a polyanionic polymer and a physiologically active peptide: CNR-PEG-CNR??(I) in the formula, CNR moieties are each independently a polymer segment containing a repeating unit that contains, as a part of a pendant group, a cyclic nitroxide radical bonded to a main polymer chain via a linking group that contains at least one amino group, and PEG is a segment that contains poly(ethylene glycol).
    Type: Application
    Filed: June 10, 2014
    Publication date: June 23, 2016
    Applicant: UNIVERSITY OF TSUKUBA
    Inventors: Yukio NAGASAKI, Junya KANEKO, Toru YOSHITOMI, Shiro ISHII