Patents by Inventor Yukio Sugimura
Yukio Sugimura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5650430Abstract: Radicicol derivatives in which one or both hydroxy groups are acylated have valuable anti-tumor activity or may be used as chemical intermediates.Type: GrantFiled: June 7, 1995Date of Patent: July 22, 1997Assignee: Sankyo Company, LimitedInventors: Yukio Sugimura, Kimio Iino, Yoshio Tsujita, Yoko Shimada, Tomowo Kobayashi, Takeshi Kagasaki
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Patent number: 5643908Abstract: Compounds having inhibitory activity against inhibitory activity against type IV collagenase and are useful as angiogenesis, cancer infiltration or cancer metastasis inhibitors. The compounds have the formula: ##STR1## in which R.sup.1 represents a group of formula: --OR.sup.3 (wherein R.sup.3 represents a hydrogen atom or an alkyl group),--NR.sup.4 R.sup.5 (wherein R.sup.4 and R.sup.5 each represents a hydrogen atom, an alkyl or alkoxy group),--NHCH(R.sup.6 COR.sup.7 (wherein R.sup.6 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, and R.sup.7 represents an alkyl group),--NHCH(R.sup.6)COOR.sup.8 (wherein R.sup.8 represents an alkyl group) or--NHCH(R.sup.6)CONR.sup.9 R.sup.10 (wherein R.sup.9 and R.sup.10 each represents a hydrogen atom or an alkyl group, or NR.sup.9 R.sup.10 together represent a heterocyclic ring group); andR.sup.2 represents a hydrogen atom, an alkyl or aralkyl group.Type: GrantFiled: June 27, 1994Date of Patent: July 1, 1997Assignee: Sankyo Company, LimitedInventors: Yukio Sugimura, Kazuhiko Tamaki, Tomowo Kobayashi, Kazuhiko Tanzawa
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Patent number: 5633243Abstract: Compounds of formula (I): ##STR1## in which: A and B are separately monoamines or together diamines; and Z is a group of formula (II) or (III): ##STR2## (in which R.sup.1, R.sup.2 and R.sup.7 are various organic groups, n is 0, 1 or 2 and X is a direct carbon-carbon bond or lower alkylene) show valuable anti-tumor activity and may be prepared by reacting an amine-platinum complex with a compound providing the group represented by Z.Type: GrantFiled: June 7, 1995Date of Patent: May 27, 1997Assignee: Sankyo Company, LimitedInventors: Yukio Sugimura, Tomoyuki Shibata, Yukiko Kameyama, Kimio Iino, Shigeki Muramatsu, Tomowo Kobayashi, Toshihiko Hashimoto
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Patent number: 5597846Abstract: A compound of the formula ##STR1## in which: R.sup.1 and R.sup.2 are independently selected from the group consisting of hydrogen atoms and groups of formula R.sup.3 --CO--, wherein R.sup.3 represents a group selected from the group consisting of unsubstituted alkyl groups having from 9 to 20 carbon atoms; substituted alkyl groups having from 10 to 20 carbon atoms; unsubstituted alkenyl groups having from 9 to 20 carbon atoms; substituted alkenyl group having from 10 to 20 carbon atoms; unsubstituted alkynyl groups having from 8 to 10 carbon atoms; and substituted alkynyl groups having from 8 to 10 carbon atoms wherein R.sup.1 and R.sup.2 are not both hydrogen atoms or acetyl groups. The compounds have antitumor activity.Type: GrantFiled: September 23, 1994Date of Patent: January 28, 1997Assignee: Sankyo Company, LimitedInventors: Yukio Sugimura, Kimio Iino, Yoshio Tsujita, Yoko Shimada, Tomowo Kobayashi, Takeshi Kagasaki
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Patent number: 5527905Abstract: Compounds of formula (I): ##STR1## in which: A and B are separately monoamines or together diamines; and Z is a group of formula (II) or (III): ##STR2## (in which R.sup.1, R.sup.2 and R.sup.7 are various organic groups, n is 0, 1 or 2 and X is a direct carbon-carbon bond or lower alkylene) show valuable anti-tumor activity and may be prepared by reacting an amine-platinum complex with a compound providing the group represented by Z.Type: GrantFiled: November 18, 1994Date of Patent: June 18, 1996Assignee: Sankyo Company, LimitedInventors: Yukio Sugimura, Tomoyuki Shibata, Yukiko Kameyama, Kimio Iino, Shigeki Muramatsu, Tomowo Kobayashi, Toshihiko Hashimoto
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Patent number: 5409912Abstract: A new compound, which we have named Leustroducsin H, has formula (I): ##STR1## and pharmaceutically acceptable salts thereof. This compound may be prepared by hydrolysis of naturally occurring Leustroducsins and the compound may be used for the treatment or prophylaxis of thrombocytopenia.Type: GrantFiled: April 8, 1994Date of Patent: April 25, 1995Assignee: Sankyo Company, LimitedInventors: Yukio Sugimura, Tomoyuki Shibata, Kazuhiko Tamaki, Shinwa Kurihara, Takafumi Kohama, Akio Shiraishi, Tomowo Kobayashi, Kazuhiko Sasagawa, Naomi Shimazaki
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Patent number: 5229290Abstract: A method is provided for the regeneration of an individual coconut plantlet. It comprises culturing a tissue explant of an undifferentiated male flower of a coconut tree in a culture medium, which contains 10-50 ppm of an auxin, 0.1-3% of a polysaccharide produced by a bacterium of Pseudomonas and 0.05-1% of activated carbon, in a dark place until a shoot-like structure appears; and then culturing under exposure to light of 3,000-20,000 luxes while repeating its subculture in a fresh culture medium.Type: GrantFiled: April 16, 1992Date of Patent: July 20, 1993Assignee: Kao CorporationInventors: Shinta Ueda, Yukio Sugimura, Kazuya Otsuji, Wakayoshi Higashi, Kikuhiko Okamoto
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Patent number: 5130858Abstract: A video signal reproducing apparatus, such as a video disc player, equipped with a field memory for special reproduction such as still-picture reproduction. The video signal writing-reading period for the field memory is set to a value which is the color subcarrier period multiplied by an integer, is also the horizontal synchronizing period multiplied by an integer and is further approximate to one field period to the greatest possible extent, to thereby eliminate the discontinuity of video signals due to the track jumping action of the pickup.Type: GrantFiled: November 16, 1990Date of Patent: July 14, 1992Assignee: Sanyo Electric Co., Ltd.Inventors: Masami Ebara, Yasuo Onishi, Yukio Sugimura, Shinya Okuno
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Patent number: 5102997Abstract: Compounds of formula (I): ##STR1## wherein: one or both of R.sup.1 and R.sup.2 are selected from a variety of organic groups;R.sup.3 is an optionally substituted heterocycle; andR.sup.4 is hydrogen or optionally substituted alkyl or alkoxy.and salts and esters thereof have valuable antibiotic activity.Type: GrantFiled: January 5, 1990Date of Patent: April 7, 1992Assignee: Sankyo Company LimitedInventors: Yukio Sugimura, Toshihiko Hashimoto, Teruo Tanaka, Kimio Iino, Tomoyuki Shibata, Masayuki Iwata
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Patent number: 5032311Abstract: A novel acidic heteropolysaccharide which comprises as its structural units arabinose, mannose, galactose, glucuronic acid, and xylose, at a specific ratio. The polysaccharide can be prepared by culturing a callus induced from a plant belonging to the genus Polianthes L. in a culture medium containing plant hormones. The polysaccharide can be used as a component of agents for external application and detergents, and provides good moisturizing effects and a smooth, satisfying feeling upon use. When formulated in detergents, they produce remarkable improvement in a clean, rich feeling upon use.Type: GrantFiled: February 27, 1990Date of Patent: July 16, 1991Assignee: KAO CorporationInventors: Kazuya Otsuji, Yasuki Honda, Kikuhiko Okamoto, Hakaru Inaoka, Satoshi Takano, Yukio Sugimura, Noriko Okamura, Kazumi Saito, Yoshinori Takema, Toshiyuki Suzuki
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Patent number: 4923809Abstract: A novel acidic heteropolysaccharide which comprises as its structural units arabinose, mannose, galactose, glucuronic acid, and xylose, at a specific ratio. The polysaccharide can be prepared by culturing a callus induced from a plant belonging to the genus Polianthes L. in a culture medium containing plant hormones. The polysaccharide can be used as a component of agents for external application and detergents, and provides good moisturizing effects and a smooth, satisfying feeling upon use. When formulated in detergents, they produce remarkable improvement in a clean, rich feeling upon use.Type: GrantFiled: March 9, 1988Date of Patent: May 8, 1990Assignee: KAO CorporationInventors: Kazuya Otsuji, Yasuki Honda, Kikuhiko Okamoto, Hakaru Inaoka, Satoshi Takano, Yukio Sugimura, Noriko Okamura, Kazumi Saito, Yoshinori Takema, Toshiyuki Suzuki
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Patent number: 4740507Abstract: Compounds of formula (I): ##STR1## (wherein R.sup.1 is carboxy, --CONR.sup.4 R.sup.5, cyano or hydroxymethyl, and R.sup.2 and R.sup.3 are hydrogen, alkyl or substituted alkyl, R.sup.4 and R.sup.5 being hydrogen or a variety of groups) have good antibiotic activity and reduced renal toxicity.Type: GrantFiled: December 23, 1985Date of Patent: April 26, 1988Assignee: Sankyo Company LimitedInventors: Yukio Sugimura, Toshihiko Hashimoto, Teruo Tanaka, Kimio Iino, Tomoyuki Shibata, Tetsuo Miyadera, Shinichi Sugawara
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Patent number: 4639441Abstract: Compounds of formula (I): ##STR1## in which: R.sup.1 represents a hydrogen atom, an alkyl group, an alkoxy group or various substituted alkyl groups;R.sup.2 represents a hydrogen atom, a group of formula ##STR2## (in which R.sup.5 and R.sup.6 each represents an alkyl group, an aralkyl group or an aryl group, or R.sup.5 and R.sup.6 together represent a nitrogen-containing heterocyclic group) or a group of formula ##STR3## (in which R.sup.7 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted amino group, a cyclic amino group, a hydroxy group, an alkoxy group, an aryloxy group, an aralkyloxy group, a substituted or unsubstituted hydrazino group or a guanidino group, and A' represents a bivalent saturated aliphatic hydrocarbon group); andR.sup.Type: GrantFiled: February 24, 1984Date of Patent: January 27, 1987Assignee: Sankyo Company LimitedInventors: Tetsuo Miyadera, Yukio Sugimura, Teruo Tanaka, Toshihiko Hashimoto, Kimio Iino, Shinichi Sugawara
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Patent number: 4613595Abstract: Compounds of formula (I): ##STR1## (wherein R.sup.1 represents a C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.3 alpha-hydroxyalkyl group;R.sup.2 represents a hydrogen atom, a substituted or unsubstituted alkyl group or a cycloalkyl group;R.sup.3 represents a hydrogen atom or an alkyl group; and n is 1 or 2) and their salts and esters have valuable antibiotic activity and can be used for the treatment of diseases caused by a wide range of pathogenic microorganisms.Type: GrantFiled: May 13, 1983Date of Patent: September 23, 1986Assignee: Sankyo Company LimitedInventors: Tetsuo Miyadera, Yukio Sugimura, Toshihiko Hashimoto, Teruo Tanaka, Kimio Iino, Tomoyuki Shibata, Shinichi Sugawara
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Patent number: 4552873Abstract: Compounds of formula (I): ##STR1## [wherein: R.sup.1 represents a hydrogen atom, an alkyl group, an alkoxy group or various substituted alkyl groups;R.sup.2 represents a group of formula ##STR2## in which ##STR3## represents an alicyclic amine group having from 4 to 8 ring atoms, optionally having a single double bond, optionally containing an additional hetero-atom and optionally having an oxo group on the ring;X represents a hydrogen atom, an alkyl group, an alkoxy group, an alkylthio group, an alkylsulphinyl group, an alkylsulphonyl group, a hydroxy group, a halogen atom or various substituted alkyl groups;Y represents a hydrogen atom, an alkyl group, an aliphatic acyl group or an acylimidoyl group; andR.sup.3 represents a carboxy group or a protected carboxy group]and pharmaceutically acceptable salts thereof have valuable antibacterial activity, especially in vivo.Type: GrantFiled: August 13, 1982Date of Patent: November 12, 1985Assignee: Sankyo Company LimitedInventors: Tetsuo Miyadera, Yukio Sugimura, Toshihiko Hashimoto, Teruo Tanaka, Kimio Iino, Tomoyuki Shibata, Shinichi Sugawara
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Patent number: 4123254Abstract: A germicidal herbicide for agriculture and horticulture, which comprises at least one compound, as an active ingredient having the formula (I);r--x--ch.dbd.ch--cooy (i)wherein R represents an alkyl or alkenyl group having 1 to 20 carbon atoms, X represents S, SO or SO.sub.2, and Y represents a hydrogen atom, an alkali metal, an alkaline earth metal, NH.sub.4, an alkyl or alkenyl group having 1 to 20 carbon atoms, a polyalcohol residue which may have therein ether bonds formed by intramolecular or intermolecular dehydration, an acetal glycerol residue, or an oxyethylene (1 to 20 units) or oxypropylene group (1 to 20 units) terminated by an alkyl group having 1 to 20 carbon atoms.Type: GrantFiled: June 22, 1977Date of Patent: October 31, 1978Assignee: Kao Soap Co., Ltd.Inventors: Tetsuji Iwasaki, Norioki Miyamoto, Yukio Sugimura, Kyozaburo Tachibana, Tsuneyuki Takeno
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Patent number: 4115103Abstract: A germicidal herbicide for agricultural and horticultural purposes, which comprises at least one compound as an active ingredient, of the formula (I): ##STR1## wherein R.sub.1 represents an alkyl or alkenyl group having 1 to 20 carbon atoms, X represents S, SO or SO.sub.2, and R.sub.2 and R.sub.3 which may be the same or different representing hydrogen, an alkyl group having 1 to 20 carbon atoms, an oxyalkylene group having 1 to 20 units of ethylene oxide or propylene oxide, 2-sulfoethyl or a salt thereof, or 2-carboxyethyl group.Type: GrantFiled: June 16, 1977Date of Patent: September 19, 1978Assignee: Kao Soap Co., Ltd.Inventors: Yukio Sugimura, Norioki Miyamoto, Tetsuji Iwasaki, Kyozaburo Tachibana, Tsuneyuki Takeno
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Patent number: 4017488Abstract: A 7.beta.-acylamino-7.alpha.-alkoxycephalosporin is prepared by reacting a 7-acylaminocephalosporin with a halogenating agent to give an iminohalide, reacting the latter compound with a base to give a keteneimine, reacting the latter compound with a halogen to give an .alpha.-halogeno iminohalide, reacting the latter compound with an alkali metal alkoxide and consecutively either subjecting the resulting compound to hydrolysis, or reacting the resulting compound with an acid or a halogenosilyl compound followed by treating the resulting compound with water.The 7.beta.-acylamino-7.alpha.-alkoxycephalosporin is useful as an antibacterial agent.Type: GrantFiled: July 29, 1975Date of Patent: April 12, 1977Assignee: Sankyo Company LimitedInventors: Tetsuo Hiraoka, Yukio Sugimura
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Patent number: 3960845Abstract: A process for preparing a 7.beta.-acylamino-7.alpha.alkoxycephalosporin or 6.beta.-acylamino-6.alpha.-alkoxypenicillin which comprises either (a) reacting a 7.beta.-(.alpha.'-halogeno or .alpha.'-hydroxyacylamino)cephalosporin or 6.beta.-(.alpha.'halogeno or .alpha.'-hydroxyacylamino)penicillin with a halogenating agent to give a .alpha.-halogeno-iminohalide, reacting the latter compound with an equimolar amount of an alkali metal alkoxide in the presence of one equivalent amount of a base to give a 7.alpha.-alkoxyketeneimine and subjecting the latter compound to hydration; or (b) reacting the 7.beta.-(.alpha.'-halogeno or .alpha.'hydroxyacylamino)cephalosporin or 6.beta.-(.alpha.'-halogeno or .alpha.'-hydroxyacylamino) penicillin with the halogenating agent to give the .alpha.Type: GrantFiled: March 4, 1975Date of Patent: June 1, 1976Assignee: Sankyo Company LimitedInventors: Tetsuo Hiraoka, Yukio Sugimura
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Patent number: RE34960Abstract: Compounds of formula (I): ##STR1## .[.[.]. wherein: R.sup.1 .[.represents a hydrogen atom, an alkyl group, an alkoxy group or various substituted alkyl groups.]. .Iadd.is hydroxyethyl; .Iaddend.R.sup.2 represents a group of formula ##STR2## in which ##STR3## .[.represents an alicyclic amine group having from 4 to 8 ring atoms, optionally having a single double bond, optionally containing an additional hetero-atom and optionally having an oxo group on the ring;.]. .Iadd.is a 3-pyrrolidinyl group; .Iaddend.X represents a hydrogen atom.[.; an alkyl group, an alkoxy group, an alkylthio group, an alkylsulphinyl group, an alkylsulphonyl group, a hydroxy group, a halogen atom or various substituted alkyl groups.].;Y represents .[.a hydrogen atom, an alkyl group, an aliphatic acyl group or an acylimidoyl.]. .Iadd.an acetylimidoyl .Iaddend.group; andR.sup.3 represents a carboxy group or a protected carboxy group.[.].].Type: GrantFiled: May 20, 1987Date of Patent: May 30, 1995Assignee: Sankyo Company, LimitedInventors: Tetsuo Miyadera, Yukio Sugimura, Toshihiko Hashimoto, Teruo Tanaka, Kimio Iino, Tomoyuki Shibata, Shinichi Sugawara