Patents by Inventor Yukitaka Ito

Yukitaka Ito has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210239682
    Abstract: The present invention provides a method for screening for platelet production promoters, the method including a step for selecting a candidate substance that significantly increases expression of TUBB1 as a platelet production promoter.
    Type: Application
    Filed: March 30, 2021
    Publication date: August 5, 2021
    Inventors: Koji Eto, Hideya Seo, Akira Ota, Yukitaka Ito, Yasuko Hazama
  • Patent number: 11016083
    Abstract: The present invention provides a method for screening for platelet production promoters, the method including a step for selecting a candidate substance that significantly increases expression of TUBB1 as a platelet production promoter.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: May 25, 2021
    Assignees: Kyoto University, Megakaryon Corporation
    Inventors: Koji Eto, Hideya Seo, Akira Ota, Yukitaka Ito, Yasuko Hazama
  • Publication number: 20210130781
    Abstract: Methods of production and apparatuses for production for stably producing healthy and functional platelets, and methods for determining operating conditions of an apparatus for producing platelets are provided. The present invention relates to methods of production comprising a step of culturing megakaryocytes in a platelet production medium C, wherein the step of culturing comprises a step of stirring a medium C in containers 1, 4 using stirring mechanisms 2, 5. In one method of production, the step of stirring comprises reciprocating stirring blades 21, 24 in the stirring mechanisms 2, 24 such that any of predetermined turbulent energy, shearing stresses, or Kolmogorov scale is produced, in the medium C. In another method of production, the step of stirring comprises pivoting a stirring blade 51 in the stirring mechanism 5 wherein a plurality of stationary members 53 is placed therearound in a bottom region 4e of the container 4 such that the step of stirring produces turbulence in the medium C.
    Type: Application
    Filed: July 5, 2018
    Publication date: May 6, 2021
    Inventors: Koji ETO, Sou NAKAMURA, Yukitaka ITO, Tomohiro SHIGEMORI, Yoshikazu KATO
  • Patent number: 10947504
    Abstract: The present invention provides a highly functional platelet production promoting agent which comprises one or a plurality of aryl hydrocarbon receptor (AhR) antagonists and one or a plurality of Rho-associated coiled-coil forming kinase (ROCK) inhibitors.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: March 16, 2021
    Assignees: Kyoto University, Megakaryon Corporation
    Inventors: Koji Eto, Sou Nakamura, Yukitaka Ito, Tomohiro Shigemori, Takeaki Dohda
  • Patent number: 10941382
    Abstract: The present invention provides: a platelet production promoter that contains one or more substances selected from the group consisting of Wnt inhibitors and FMS-like tyrosine kinase (FLT) inhibitors; and a platelet production method that uses this platelet production promoter.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: March 9, 2021
    Assignees: Kyoto University, Megakaryon Corporation
    Inventors: Koji Eto, Hideya Seo, Akira Ota, Yukitaka Ito, Yasuko Hazama
  • Publication number: 20200216807
    Abstract: Healthy functional platelets are mass produced. A method for producing platelets, comprising: (1) a culture step of culturing megakaryocytes in a platelet producing medium in the presence of mechanical stress and platelet production promoting factors including MIF, NRDc, IGFBP2, TSP-1, PAI-1, and CCL5, and (2) a harvest step of harvesting the platelets obtained by the culture step; wherein the culture step comprises: (a) a step of promoting a release of the platelet production promoting factors from megakaryocytes by mechanical stress; and/or (b) a step of externally adding platelet production promoting factors including MIF, NRDc, and IGFBP2.
    Type: Application
    Filed: March 5, 2018
    Publication date: July 9, 2020
    Inventors: KOJI ETO, SOU NAKAMURA, YUKITAKA ITO
  • Publication number: 20190071636
    Abstract: Provided is a method for inducing mesoderm, comprising a step of bringing pluripotent stem cells into contact with bone morphogenetic protein 4 (BMP4) or CHIR for at least 3 days.
    Type: Application
    Filed: March 22, 2017
    Publication date: March 7, 2019
    Inventors: Koji ETO, Hiroshi ENDO, Yukitaka ITO, Junichi FUKUNAGA
  • Publication number: 20190048317
    Abstract: The present invention provides a highly functional platelet production promoting agent which comprises one or a plurality of aryl hydrocarbon receptor (AhR) antagonists and one or a plurality of Rho-associated coiled-coil forming kinase (ROCK) inhibitors.
    Type: Application
    Filed: June 16, 2016
    Publication date: February 14, 2019
    Inventors: Koji Eto, Sou Nakamura, Yukitaka Ito, Tomohiro Shigemori, Takeaki Dohda
  • Publication number: 20190032015
    Abstract: The present invention provides: a platelet production promoter that contains one or more substances selected from the group consisting of Wnt inhibitors and FMS-like tyrosine kinase (FLT) inhibitors; and a platelet production method that uses this platelet production promoter.
    Type: Application
    Filed: January 30, 2017
    Publication date: January 31, 2019
    Applicants: Kyoto University, MEGAKARYON CORPORATION
    Inventors: Koji Eto, Hideya Seo, Akira Ota, Yukitaka Ito, Yasuko Hazama
  • Publication number: 20190033296
    Abstract: The present invention provides a method for screening for platelet production promoters, the method including a step for selecting a candidate substance that significantly increases expression of TUBB1 as a platelet production promoter.
    Type: Application
    Filed: January 30, 2017
    Publication date: January 31, 2019
    Applicants: Kyoto University, Megakaryon Corporation
    Inventors: Koji Eto, Hideya Seo, Akira Ota, Yukitaka Ito, Yasuko Hazama