Patents by Inventor Yukitsuka Kudo
Yukitsuka Kudo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210230139Abstract: The present invention provides a compound represented by formula (I) that can image monoamine oxidase-B with high specificity and selectivity for monoamine oxidase-B and with good sensitivity, or a pharmaceutically acceptable salt or solvate thereof.Type: ApplicationFiled: August 6, 2019Publication date: July 29, 2021Applicant: TOHOKU UNIVERSITYInventors: Ryuichi HARADA, Shozo FURUMOTO, Yukitsuka KUDO, Nobuyuki OKAMURA
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Patent number: 9701637Abstract: An object of the present invention is to provide a probe for imaging a ?-sheet structure protein which can be used for the diagnosis of conformational diseases, particularly disease (tauopathy) having a cardinal symptom such as intracerebral accumulation of tau protein, for example, Alzheimer's disease. Another object of the present invention is to provide a compound which is highly specific to tau and can image tau with satisfactory sensitivity, and also has high brain transition, low or non-recognized bone-seeking properties and low or non-recognized toxicity. According to the present invention, the above problems are solved by providing a compound of a formula I (wherein A, R1, R2, R3, R4, R5, R6, Ra and Rb are as defined in the present description) or a pharmaceutically acceptable salt or solvate thereof.Type: GrantFiled: May 31, 2016Date of Patent: July 11, 2017Assignee: GE Healthcare LimitedInventors: Yukitsuka Kudo, Shozo Furumoto, Nobuyuki Okamura
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Patent number: 9452985Abstract: An object of the present invention is to provide a probe for imaging a ?-sheet structure protein which can be used for the diagnosis of conformational diseases, particularly disease (tauopathy) having a cardinal symptom such as intracerebral accumulation of tau protein, for example, Alzheimer's disease. Another object of the present invention is to provide a compound which is highly specific to tau and can image tau with satisfactory sensitivity, and also has high brain transition, low or non-recognized bone-seeking properties and low or non-recognized toxicity. According to the present invention, the above problems are solved by providing a compound of a formula I (wherein A, R1, R2, R3, R4, R5, R6, Ra and Rb are as defined in the present description) or a pharmaceutically acceptable salt or solvate thereof.Type: GrantFiled: September 22, 2015Date of Patent: September 27, 2016Assignee: GE Healthcare LimitedInventors: Yukitsuka Kudo, Shozo Furumoto, Nobuyuki Okamura
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Publication number: 20160271278Abstract: An object of the present invention is to provide a probe for imaging a ?-sheet structure protein which can be used for the diagnosis of conformational diseases, particularly disease (tauopathy) having a cardinal symptom such as intracerebral accumulation of tau protein, for example, Alzheimer's disease. Another object of the present invention is to provide a compound which is highly specific to tau and can image tau with satisfactory sensitivity, and also has high brain transition, low or non-recognized bone-seeking properties and low or non-recognized toxicity. According to the present invention, the above problems are solved by providing a compound of a formula I (wherein A, R1, R2, R3, R4, R5, R6, Ra and Rb are as defined in the present description) or a pharmaceutically acceptable salt or solvate thereof.Type: ApplicationFiled: May 31, 2016Publication date: September 22, 2016Inventors: Yukitsuka KUDO, Shozo FURUMOTO, Nobuyuki OKAMURA
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Publication number: 20160244411Abstract: An object of the present invention is to provide a compound represented by formula (I) which is highly specific to tau and can image tau with satisfactory sensitivity, and also has high brain transition, low or non-recognized bone-seeking properties and low or undetected toxicity.Type: ApplicationFiled: October 22, 2014Publication date: August 25, 2016Applicant: CLINO LTD.Inventors: Yukitsuka KUDO, Nobuyuki OKAMURA, Shozo FURUMOTO
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Patent number: 9249101Abstract: An object of the present invention is to provide a probe for imaging a ?-sheet structure protein which can be used for the diagnosis of conformational diseases, particularly disease (tauopathy) having a cardinal symptom such as intracerebral accumulation of tau protein, for example, Alzheimer's disease. Another object of the present invention is to provide a compound which is highly specific to tau and can image tau with satisfactory sensitivity, and also has high brain transition, low or non-recognized bone-seeking properties and low or non-recognized toxicity. According to the present invention, the above problems are solved by providing a compound of a formula I (wherein A, R1, R2, R3, R4, R5, R6, Ra and Rb are as defined in the present description) or a pharmaceutically acceptable salt or solvate thereof.Type: GrantFiled: October 28, 2011Date of Patent: February 2, 2016Assignee: CLINO LTD.Inventors: Yukitsuka Kudo, Shozo Furumoto, Nobuyuki Okamura
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Publication number: 20160008494Abstract: An object of the present invention is to provide a probe for imaging a ?-sheet structure protein which can be used for the diagnosis of conformational diseases, particularly disease (tauopathy) having a cardinal symptom such as intracerebral accumulation of tau protein, for example, Alzheimer's disease. Another object of the present invention is to provide a compound which is highly specific to tau and can image tau with satisfactory sensitivity, and also has high brain transition, low or non-recognized bone-seeking properties and low or non-recognized toxicity. According to the present invention, the above problems are solved by providing a compound of a formula I (wherein A, R1, R2, R3, R4, R5, R6, Ra and Rb are as defined in the present description) or a pharmaceutically acceptable salt or solvate thereof.Type: ApplicationFiled: September 22, 2015Publication date: January 14, 2016Inventors: Yukitsuka KUDO, Shozo FURUMOTO, Nobuyuki OKAMURA
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Publication number: 20130324523Abstract: An object of the present invention is to provide a probe for imaging a ?-sheet structure protein which can be used for the diagnosis of conformational diseases, particularly disease (tauopathy) having a cardinal symptom such as intracerebral accumulation of tau protein, for example, Alzheimer's disease. Another object of the present invention is to provide a compound which is highly specific to tau and can image tau with satisfactory sensitivity, and also has high brain transition, low or non-recognized bone-seeking properties and low or non-recognized toxicity. According to the present invention, the above problems are solved by providing a compound of a formula I (wherein A, R1, R2, R3, R4, R5, R6, Ra and Rb are as defined in the present description) or a pharmaceutically acceptable salt or solvate thereof.Type: ApplicationFiled: October 28, 2011Publication date: December 5, 2013Applicant: CLINO LTD.Inventors: Yukitsuka Kudo, Shozo Furumoto, Nobuyuki Okamura
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Publication number: 20110190492Abstract: The invention provides a probe compound useful for early diagnosis of conformation disease, a composition and a kit comprising it for diagnosis for conformation disease, and a medical composition for treatment and/or prevention of conformation disease.Type: ApplicationFiled: April 14, 2011Publication date: August 4, 2011Applicant: TOHOKU UNIVERSITYInventors: Yukitsuka KUDO, Hiroyuki ARAI, Nobuyuki OKAMURA, Masahiro MARUYAMA, Syozo FURUMOTO, Katsumi DOH-URA
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Patent number: 7910579Abstract: It is intended to provide a benzoxazole derivative or a pharmaceutically acceptable salt or solvate thereof which is useful in the early diagnosis of a conformation disease; a composition or a kit containing the same for diagnosing a conformation disease; a medical composition for treating and/or preventing a conformation disease; and so on.Type: GrantFiled: July 4, 2007Date of Patent: March 22, 2011Assignee: Tohoku UniversityInventors: Yukitsuka Kudo, Syozo Furumoto, Nobuyuki Okamura
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Publication number: 20100272642Abstract: Disclosed are: a PET probe compound having an alkoxy group substituted by a fluorine and a hydroxy group, which is useful for the early diagnosis of a conformational disease; a pharmaceutical composition for the treatment and/or prevention of a conformational disease, which comprises the compound; and others.Type: ApplicationFiled: June 17, 2008Publication date: October 28, 2010Applicant: TOHOKU UNIVERSITYInventors: Yukitsuka Kudo, Syozo Furumoto, Nobuyuki Okamura
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Publication number: 20100021385Abstract: It is intended to provide a benzoxazole derivative or a pharmaceutically acceptable salt or solvate thereof which is useful in the early diagnosis of a conformation disease; a composition or a kit containing the same for diagnosing a conformation disease; a medical composition for treating and/or preventing a conformation disease; and so on.Type: ApplicationFiled: July 4, 2007Publication date: January 28, 2010Applicant: TOHOKU UNIVERSITYInventors: Yukitsuka Kudo, Syozo Furumoto, Nobuyuki Okamura
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Publication number: 20090185975Abstract: The invention provides a probe compound useful for early diagnosis of conformation disease, a composition and a kit comprising it for diagnosis for conformation disease, and a medical composition for treatment and/or prevention of conformation disease.Type: ApplicationFiled: December 25, 2006Publication date: July 23, 2009Applicant: TOHOKU UNIVERSITYInventors: Yukitsuka Kudo, Hiroyuki Arai, Nobuyuki Okamura, Masahiro Maruyama, Syozo Furumoto, Katsumi Doh-Ura
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Patent number: 7118730Abstract: The present invention provides compounds, or salts or solvates thereof, which can be used as probes for the imaging diagnosis of diseases in which tau protein accumulates, and compositions and kits comprising such compounds, or salts or solvates thereof. The present invention also provides a method for staining neurofibrillary tangles in brain samples, and a pharmaceutical composition for the treatment and/or prophylaxis of a disease in which ?-sheet structure is the cause or possible cause.Type: GrantFiled: November 28, 2003Date of Patent: October 10, 2006Assignee: BF Research Institute, Inc.Inventors: Yukitsuka Kudo, Masako Suzuki, Takahiro Suemoto, Nobuyuki Okamura, Tsuyoshi Shiomitsu, Hiroshi Shimazu
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Publication number: 20060018825Abstract: The present invention provides compounds having high affinity for amyloid ?-protein which are for the diagnosis of diseases in which amyloid ?-protein accumulates, for agents for specifically staining amyloid ?-protein, and for the treatment and/or prophylaxis of diseases in which amyloid ?-protein accumulates. The present invention also provides probes and staining agents for neurofibrillary tangles.Type: ApplicationFiled: August 11, 2004Publication date: January 26, 2006Applicant: BF RESEARCH INSTITUTE, INC.Inventors: Yukitsuka Kudo, Masako Suzuki, Takahiro Suemoto, Nobuyuki Okamura, Tsuyoshi Shiomitsu, Hiroshi Shimazu
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Publication number: 20050260126Abstract: A compound, which is used for the diagnosis and the prophylaxis/treatment of diseases in which prion protein is accumulated, or specific staining of abnormal prion protein in samples, represented by the formula (I) or (II): or a salt or solvate thereof.Type: ApplicationFiled: August 29, 2003Publication date: November 24, 2005Inventors: Yukitsuka Kudo, Tohru Sawada, Katsumi Doh-Ura
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Publication number: 20050009865Abstract: The present invention provides compounds, or salts or solvates thereof, which can be used as probes for the imaging diagnosis of diseases in which tau protein accumulates, and compositions and kits comprising such compounds, or salts or solvates thereof. The present invention also provides a method for staining neurofibrillary tangles in brain samples, and a pharmaceutical composition for the treatment and/or prophylaxis of a disease in which ?-sheet structure is the cause or possible cause.Type: ApplicationFiled: November 28, 2003Publication date: January 13, 2005Inventors: Yukitsuka Kudo, Masako Suzuki, Takahiro Suemoto, Nobuyuki Okamura, Tsuyoshi Shiomitsu, Hiroshi Shimazu
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Patent number: 5496815Abstract: Thiazine derivatives of the formula [I]: ##STR1## wherein R.sup.1, R.sup.2, R.sup.4 and R.sup.5 are each hydrogen atom; R.sup.3 is hydrogen atom or a halogen atom; X is sulfur atom; R.sup.6 is naphthyl, a sulfur-containing monoheterocyclic group or a substituted phenyl; Z.sup.1 is two hydrogen atoms; Z.sup.2 is oxygen atom; A is a lower alkylene; R.sup.7 and R.sup.8 are the same or different and are each i) hydrogen atom, ii) a lower alkyl, iii) a lower alkenyl, iv) a lower alkynyl, or v) a lower alkyl which is substituted by a substituted phenyl, or both form together with the adjacent nitrogen atom a nitrogen-containing monoheterocyclic group; except for the compound [I] wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are each hydrogen atom, X is sulfur atom, R.sup.6 is a halogenophenyl, Z.sup.1 is two hydrogen atoms, Z.sup.2 is oxygen atom, A is a lower alkylene, R.sup.7 and R.sup.Type: GrantFiled: October 28, 1993Date of Patent: March 5, 1996Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Masakatsu Ozeki, Shin-ichi Kodato, Kousuke Yasuda, Yukitsuka Kudo, Kayoko Maeda
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Patent number: 5281592Abstract: Thiazine derivatives of the formula [I]: ##STR1## wherein R.sup.1 and R.sup.2 are both H or form a naphthalene ring together with the benzene ring; R.sup.3 and R.sup.4 are both H, or one of them is halogen and another is H; X is S or O; R.sup.5 and R.sup.6 are each i) H, ii) lower alkyl, iii) cycloalkyl, iv) substituted phenyl, v) naphthyl, vi) lower alkyl which is substituted by substituted or unsubstituted phenyl, or vii) S-containing heterocyclic group; one of Z.sup.1 and Z.sup.2 is O and another is H.sub.2 ; A is lower alkylene; R.sup.7 and R.sup.8 are each i) H, ii) lower alkyl, iii) lower alkenyl, iv) lower alkynyl, or v) lower alkyl which is substituted by substituted or unsubstituted phenyl, or both form together N-containing heterocyclic group; provided that when both of R.sup.1 and R.sup.2 are H, Z.sup.2 is O and either one of R.sup.5 and R.sup.Type: GrantFiled: September 23, 1992Date of Patent: January 25, 1994Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Masakatsu Ozeki, Shin-ichi Kodato, Kousuke Yasuda, Yukitsuka Kudo, Kayoko Maeda
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Patent number: 5246929Abstract: Thiazine (or oxazine) derivatives of the formula [I]: ##STR1## wherein R.sup.1 and R.sup.2 are both H or form a naphthalene ring together with the benzene ring; R.sup.3 and R.sup.4 are both H, or one of them is halogen and another is H; X is S or O; R.sup.5 and R.sup.6 are each i) H, ii) lower alkyl, iii) cycloalkyl, iv) substituted phenyl, v) naphthyl, vi) lower alkyl which is substituted by substituted or unsubstituted phenyl, or vii) S-containing heterocyclic group; one of Z.sup.1 and Z.sup.2 is O and another is H.sub.2 ; A is lower alkylene; R.sup.7 and R.sup.8 are each i) H, ii) lower alkyl, iii) lower alkenyl, iv) lower alkynyl, or v) lower alkyl which is substituted by substituted or unsubstituted phenyl, or both form together N-containing heterocyclic group; provided that when both of R.sup.1 and R.sup.2 are H, Z.sup.2 is O and either one of R.sup.5 and R.sup.Type: GrantFiled: January 31, 1991Date of Patent: September 21, 1993Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Masakatsu Ozeki, Shin-ichi Kodato, Kousuke Yasuda, Yukitsuka Kudo, Kayoko Maeda