Abstract: The disclosure provides a method for treating a subject afflicted with a cancer comprising administering to the subject a therapeutically effective amount of an anti-PD-1 antagonist, e.g., an anti-PD-1 or anti-PD-L1 antibody, in combination with an indoleamine 2,3-dioxygenase inhibitor, wherein the subject is identified as exhibiting a combined biomarker comprising (a) a high IFN? inflammatory signature score and (b) a low tryptophan 2,3-dioxygenase 2 (TDO2) gene expression score. The high IFN? inflammatory signature score is determined by measuring the expression of a panel of IFN? related inflammatory genes in a cancer sample obtained from the subject, wherein the gene panel comprises, e.g., IFN?, CXCL10, CXCL9, HLA-DRA, IDO1, and STAT1. In some aspects, the gene panel further comprises CCR5, CXCL11, GZMA, and PRF1. In some aspects, the gene panel comprises CXCR6, TIGIT, PD-L1, PD-L2, LAG3, NKG7, PSMB10, CMKLR1, CD8A, IDO1, CCL5, CXCL9, HLA.DQA1, CD276, HLA.DRB1, STAT1, HLA.E, and TDO2.

Abstract: The present invention relates to a method of predicting the likelihood that a patient will respond therapeutically to a pancreatic cancer treatment comprising the administration of 2-[(2S)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3H)-one (Compound 1) and/or tautomers thereof or a pharmaceutically acceptable salt or hydrate thereof, comprising the steps of: STEP (1): determining a KRAS gene mutation status of a sample from a patient, and STEP (2): predicting an increased likelihood that the patient will respond therapeutically to the pancreatic cancer treatment if the patient has the presence of KRAS gene mutation(s), and to methods of treating pancreatic cancer.

Abstract: A power supply and demand adjusting system 107 includes a system power receiving section that receives commercial electric power from a power company, a charger that charges an electric vehicle of a user, which is mounted with a storage battery, with the commercial electric power received by the system power receiving section, and an operation management server 103 that includes an information replacing function 104 for converting incentive information 21 related to power supply and demand adjustment for a power resale organization presented from an external institution into incentive information 22 related to power consumption for the user.

Abstract: A liquid crystal display element includes a liquid crystal composition sandwiched between substrates, wherein at least two types of liquid crystal compositions which exhibit liquid crystal phase in different temperature ranges are contained within each one pixel, and each of the at least two types of liquid crystal compositions is sealed and isolated within each pixel.

Abstract: A liquid crystal display element includes a liquid crystal composition sandwiched between substrates, wherein at least two types of liquid crystal compositions which exhibit liquid crystal phase in different temperature ranges are contained within each one pixel, and each of the at least two types of liquid crystal compositions is sealed and isolated within each pixel.

Abstract: A clear ice making apparatus includes: a freezing space; a tray placed in the freezing space and having a lower temperature at a bottom part thereof than at an upper part thereof; and a water supply unit of supplying water to the tray from the top thereof, in which ice is made at an ice making rate of 5 ?m/s or lower, a part of a liquid-phase section of water in the tray which part is in contact with atmosphere is frozen to complete the ice making, the liquid-phase section of water is not entirely supercooled before the ice making is completed, and the concentration of air in the liquid-phase section of water in the tray is equal to or lower than an excessive concentration of air.

Abstract: A clear ice making apparatus includes: a freezing space; a tray placed in the freezing space and having a lower temperature at a bottom part thereof than at an upper part thereof; and a water supply unit of supplying water to the tray from the top thereof, in which an ice is made at an ice making rate of 5 &mgr;m/s or lower, a part of a liquid-phase section of water in the tray which part is in contact with atmosphere is frozen to complete the ice making, the liquid-phase section of water is not entirely supercooled before the ice making is completed, and the concentration of air in the liquid-phase section of water in the tray is equal to or lower than an excessive concentration of air.

Abstract: A diluent is discharged by a dispensing device into a dilution bath 11 containing a sample, and a given amount of a diluted sample 12 is sucked from the upper face by the dispensing device and discarded by discharging it into a waste fluid cup to remove many small bubbles 13 generated during the preparation of the diluted sample used for determination. The diluted sample 12 remaining in the dilution bath 11 is used for determination to improve the precision and reproducibility of determination and to prevent failure of the dispensing device due to inclusion of bubbles.