Patents by Inventor Yuko ISHINO

Yuko ISHINO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production method for 2-fluoro-4-borono-L-phenylalanine, and precursor of 2-fluoro-4-borono-L-phenylalanine
    Patent number: 10344042
    Abstract: The present invention involves preparing compounds represented by the following formula: from a compound of the following formula: In these formulae: R1 represents a Br group, an iodine group, a Cl group, an NO2 group, or an NH2 group; R2 represents a halogen group, an NO2 group, an NH2 group, Sn(R6)3, N?N—NR7R8, OSO2R9, N R10R11, phenyliodonium, a heterocyclic group iodine, boric acid, or a borate ester; R30 represents a protective group PG1; R40 or R50 represent hydrogen, a protective group PG2, or C6H5(C6H5)C?N, in which NR40R50 are together.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: July 9, 2019
    Assignees: Stella Pharma Corporation, Osaka Prefecture University Public Corporation
    Inventors: Hiroshi Takenaka, Yoichiro Ohta, Yusuke Taguchi, Sayuri Ueda, Yuko Ishino, Tomohiro Yoshikawa, Hideki Nakashima, Kohki Uehara, Mitsunori Kirihata
  • Production method for 2-fluoro-4-borono-L-phenylalanine, and precursor of 2-fluoro-4-borono-L-phenylalanine
    Patent number: 10005794
    Abstract: The present invention involves preparing compounds represented by the formula. (In the formula: R1 represents a Br group, an iodine group, a Cl group, an NO2 group, or an NH2 group; R2 represents a halogen group, an NO2 group, an NH2 group, Sn(R6)3, N?N—NR7R8, OSO2R9, NR10R11, phenyliodonium, a heterocyclic group iodine, boric acid, or a borate ester; R30 represents a protective group PG1; R40 or R50 represent hydrogen, a protective group PG2, or C6H5(C6H5)C?N, wherein NR40R50 are together.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: June 26, 2018
    Assignees: STELLA PHARMA CORPORATION, OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION
    Inventors: Hiroshi Takenaka, Yoichiro Ohta, Yusuke Taguchi, Sayuri Ueda, Yuko Ishino, Tomohiro Yoshikawa, Hideki Nakashima, Kohki Uehara, Mitsunori Kirihata
  • Method for producing 4-borono-L-phenylalanine having 18F atom introduced thereinto, and precursor of 4-borono-L-phenylalanine having 18F atom introduced thereinto
    Patent number: 9815855
    Abstract: 18F-labeled 4-boronophenylalanine (BPA) can be produced by preparing and further processing a precursor of 18F-labeled BPA represented by the following formula: in which R1 represents a bromo group, an iodo group, a fluoro group, a diazaborinane derivative, BX3? or BX3?M+ (wherein X represents a halogen atom; and M+ represents a monovalent monoatomic cation, a polyatomic cation or a complex cation).
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: November 14, 2017
    Assignees: Stella Pharma Corporation, Osaka Prefecture University Public Corporation
    Inventors: Hiroshi Takenaka, Yoichiro Ohta, Yusuke Taguchi, Sayuri Ueda, Yuko Ishino, Tomohiro Yoshikawa, Hideki Nakashima, Kohki Uehara, Mitsunori Kirihata
  • PRODUCTION METHOD FOR 2-FLUORO-4-BORONO-L-PHENYLALANINE, AND PRECURSOR OF 2-FLUORO-4-BORONO-L-PHENYLALANINE
    Publication number: 20170283441
    Abstract: The present invention involves preparing compounds represented by the following formula: from a compound of the following formula: In these formulae: R1 represents a Br group, an iodine group, a Cl group, an NO2 group, or an NH2 group; R2 represents a halogen group, an NO2 group, an NH2 group, Sn(R6)3, N?N—NR7R8, OSO2R9, N R10R11, phenyliodonium, a heterocyclic group iodine, boric acid, or a borate ester; R30 represents a protective group PG1; R40 or R50 represent hydrogen, a protective group PG2, or C6H5(C6H5)C?N, in which NR40R50 are together.
    Type: Application
    Filed: June 16, 2017
    Publication date: October 5, 2017
    Inventors: Hiroshi Takenaka, Yoichiro Ohta, Yusuke Taguchi, Sayuri Ueda, Yuko Ishino, Tomohiro Yoshikawa, Hideki Nakashima, Kohki Uehara, Mitsunori Kirihata
  • METHOD FOR PRODUCING 4-BORONO-L-PHENYLALANINE HAVING 18F ATOM INTRODUCED THEREINTO, AND PRECURSOR OF 4-BORONO-L-PHENYLALANINE HAVING 18F ATOM INTRODUCED THEREINTO
    Publication number: 20170015684
    Abstract: 18F-labeled 4-boronophenylalanine (BPA) can be produced by preparing and further processing a precursor of 18F-labeled BPA represented by the following formula: in which R1 represents a bromo group, an iodo group, a fluoro group, a diazaborinane derivative, BX3? or BX3?M+ (wherein X represents a halogen atom; and M+ represents a monovalent monoatomic cation, a polyatomic cation or a complex cation).
    Type: Application
    Filed: January 28, 2015
    Publication date: January 19, 2017
    Inventors: Hiroshi TAKENAKA, Yoichiro OHTA, Yusuke TAGUCHI, Sayuri UEDA, Yuko ISHINO, Tomohiro YOSHIKAWA, Hideki NAKASHIMA, Kohki UEHARA, Mitsunori KIRIHATA
  • PRODUCTION METHOD FOR 2-FLUORO-4-BORONO-L-PHENYLALANINE, AND PRECURSOR OF 2-FLUORO-4-BORONO-L-PHENYLALANINE
    Publication number: 20160311836
    Abstract: The present invention involves preparing compounds represented by the formula. (In the formula: R1 represents a Br group, an iodine group, a Cl group, an NO2 group, or an NH2 group; R2 represents a halogen group, an NO2 group, an NH2 group, Sn(R6)3, N?N—NR7R8, OSO2R9, NR10R11, phenyliodonium, a heterocyclic group iodine, boric acid, or a borate ester; R30 represents a protective group PG1; R40 or R50 represent hydrogen, a protective group PG2, or C6H5(C6H5)C?N, wherein NR40R50 are together.
    Type: Application
    Filed: December 16, 2014
    Publication date: October 27, 2016
    Inventors: Hiroshi Takenaka, Yoichiro Ohta, Yusuke Taguchi, Sayuri Ueda, Yuko Ishino, Tomohiro Yoshikawa, Hideki Nakashima, Kohki Uehara, Mitsunori Kirihata
  • Chiral 4-boronophenylalanine (BPA) derivative and method for producing same, and method for producing F-labeled BPA using said derivative
    Patent number: 9409926
    Abstract: Provided are: a novel chiral 4-boronophenylalanine (BPA) derivative; a method for producing the derivative; and a method for producing 18F-2-fluoro-4-borono-L-phenylalanine (18F-labeled BPA; 18F-BPA) using the derivative. A compound represented by formula (1) is prepared. In the formula, R represents BR3R4, BX3? or BX3?M+ (wherein X represents a halogen atom, and M+ represents a monovalent monoatomic cation, a polyatomic cation or a complex cation); R1 represents a hydrogen atom or a protecting group PG1; R2 represents a hydrogen atom or a protecting group PG2; R3 and R4 independently represent OH, or R3, R4 and B together form a ring that serves as a protecting group; and Y represents a halogen atom, NO2, NH2, Sn(R6)3, N?N—NR7R8, OSO2R9, NR10R11, a substituted or unsubstituted phenyliodo group or a substituted or unsubstituted heterocyclic iodo group. The compound is reacted with a fluorination reagent to prepare 18F-labeled BPA.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: August 9, 2016
    Assignee: STELLA PHARMA CORPORATION; OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION
    Inventors: Hiroshi Takenaka, Yoichiro Ohta, Yusuke Taguchi, Sayuri Ueda, Yuko Ishino, Hideki Nakashima, Kohki Uehara, Mitsunori Kirihata
  • CHIRAL 4-BORONOPHENYLALANINE (BPA) DERIVATIVE AND METHOD FOR PRODUCING SAME, AND METHOD FOR PRODUCING 18F-LABELED BPA USING SAID DERIVATIVE
    Publication number: 20150329564
    Abstract: Provided are: a novel chiral 4-boronophenylalanine (BPA) derivative; a method for producing the derivative; and a method for producing 18F-2-fluoro-4-borono-L-phenylalanine (18F-labeled BPA; 18F-BPA) using the derivative. A compound represented by formula (1) is prepared. In the formula, R represents BR3R4, BX3? or BX3?M+ (wherein X represents a halogen atom, and M+ represents a monovalent monoatomic cation, a polyatomic cation or a complex cation); R1 represents a hydrogen atom or a protecting group PG1; R2 represents a hydrogen atom or a protecting group PG2; R3 and R4 independently represent OH, or R3, R4 and B together form a ring that serves as a protecting group; and Y represents a halogen atom, NO2, NH2, Sn(R6)3, N?N—NR7R8, OSO2R9, NR10R11, a substituted or unsubstituted phenyliodo group or a substituted or unsubstituted heterocyclic iodo group. The compound is reacted with a fluorination reagent to prepare 18F-labeled BPA.
    Type: Application
    Filed: October 8, 2013
    Publication date: November 19, 2015
    Inventors: Hiroshi TAKENAKA, Yoichiro OHTA, Yusuke TAGUCHI, Sayuri UEDA, Yuko ISHINO, Hideki NAKASHIMA, Kohki UEHARA, Mitsunori KIRIHATA