Patents by Inventor Yuko Kiyosue

Yuko Kiyosue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cultured cell lines expressing mutant gene
    Patent number: 7951930
    Abstract: Using protein visualization techniques, cell lines stably expressing GFP-fused full-length and mutant APCs were obtained from cultured Xenopus laevis renal epithelial A6 cells. The use of these cells showed that mutant APCs, whose C-terminal region is absent, induced piling up of cells. Furthermore, piled up cells from mutant APC-expressing cell lines were proven to maintain the intercellular adhesive structure, representing a phenomenon similar to polyp formation in individual organisms (mice).
    Type: Grant
    Filed: March 21, 2008
    Date of Patent: May 31, 2011
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Yuko Kiyosue, Hiroyuki Sasaki, Shoichiro Tsukita
  • CULTURED XENOPUS LAEVIS CELL LINES EXPRESSING MUTANT ADENOMATOUS POLYPOSIS COLI GENE
    Publication number: 20100003747
    Abstract: Using protein visualization techniques, cell lines stably expressing GFP-fused full-length and mutant APCs were obtained from cultured Xenopus laevis renal epithelial A6 cells. The use of these cells showed that mutant APCs, whose C-terminal region is absent, induced piling up of cells. Furthermore, piled up cells from mutant APC-expressing cell lines were proven to maintain the intercellular adhesive structure, representing a phenomenon similar to polyp formation in individual organisms (mice).
    Type: Application
    Filed: March 21, 2008
    Publication date: January 7, 2010
    Applicant: Eisai Co., Ltd.
    Inventors: Yuko Kiyosue, Hiroyuki Sasaki, Shoichiro Tsukita
  • TARGET MOLECULES OF PLADIENOLIDES, COMPOUNDS BINDING TO SUCH TARGET MOLECULES, AND SCREENING METHOD THEREOF
    Publication number: 20090227795
    Abstract: A method of measuring the binding activity of a test compound to a splicing factor 3b (SF3b), which comprises the following steps of: (a) contacting a labeled pladienolide compound and a test compound with a cell or a cell fraction; and (b) measuring the distribution of the bound labeled compound. The method enables to screen for a novel active compound capable of acting on (binding to) a pladienolide target molecule or the like.
    Type: Application
    Filed: August 2, 2007
    Publication date: September 10, 2009
    Applicant: Eisai R & D Management Co., Ltd.
    Inventors: Yoshihiko Kotake, Koji Sagane, Takashi Owa, Yoshiharu Mizui, Hajime Shimizu, Yuko Kiyosue
  • Cultured cell lines expressing mutant gene
    Patent number: 7371843
    Abstract: Using protein visualization techniques, cell lines stably expressing GFP-fused full-length and mutant APCs were obtained from cultured Xenopus laevis renal epithelial A6 cells. The use of these cells showed that mutant APCs, whose C-terminal region is absent, induced piling up of cells. Furthermore, piled up cells from mutant APC-expressing cell lines were proven to maintain the intercellular adhesive structure, representing a phenomenon similar to polyp formation in individual organisms (mice).
    Type: Grant
    Filed: August 19, 2003
    Date of Patent: May 13, 2008
    Assignee: Eisai Co., Ltd.
    Inventors: Yuko Kiyosue, Hiroyuki Sasaki, Shoichiro Tsukita
  • Cultured xenopus cell line expressing mutated apc
    Publication number: 20060100418
    Abstract: Using protein visualization techniques, cell lines stably expressing GFP-fused full-length and mutant APCs were obtained from cultured Xenopus laevis renal epithelial A6 cells. The use of these cells showed that mutant APCs, whose C-terminal region is absent, induced piling up of cells. Furthermore, piled up cells from mutant APC-expressing cell lines were proven to maintain the intercellular adhesive structure, representing a phenomenon similar to polyp formation in individual organisms (mice).
    Type: Application
    Filed: August 19, 2003
    Publication date: May 11, 2006
    Applicant: Eisai Co., Ltd.
    Inventors: Yuko Kiyosue, Hiroyuki Sasaki, Shoichiro Tsukita