Abstract: The purpose of the present invention is to provide a novel stereoselective method for preparing a cyclic dinucleotide derivative and a production intermediate therefor, which can be used for an antibody-immunostimulant conjugate. Also provided is a method for producing a cyclic dinucleotide-linker and an antibody-immunostimulant conjugate while using the above production method. Further provided is a method for preparing a cyclic dinucleotide derivative, the method including the step of subjecting a compound (I) and a compound (IV) to stereoselective condensation using an optically active phosphitylating agent (Rc-II) or (Sc-II).

Abstract: The simulator includes a chemical liquid information acquisition section configured to acquire an amount of contrast medium, a target value acquisition section configured to acquire a target duration for which a target pixel value is maintained, a protocol acquisition section configured to acquire a contrast medium injection protocol, and a prediction section for determining a predicted duration, the prediction section configured to simulate the time-dependent change in the pixel value in the tissue of the subject based on the injection protocol and the amount of the contrast medium, and the prediction section compares the predicted duration with the target duration to re-simulate, in a case where the predicted duration is shorter than the target duration, the time-dependent change in a condition where a greater amount of the contrast medium than the amount of the contrast medium used in the simulation is injected to redetermine the predicted duration, and in a case where the predicted duration is longer than

Abstract: In order to achieve a prediction approximating an actual change with time of a pixel value in a tissue with higher accuracy, provided is a simulator, which is configured to predict a change with time of a pixel value in a tissue of an object, including: an object information acquisition unit configured to acquire information on the object; a protocol acquisition unit configured to acquire an injection protocol for a contrast medium; a tissue information acquisition unit configured to acquire information on the tissue; and a prediction unit configured to predict, based on the information on the object, the injection protocol, and the information on the tissue, a change with time of a pixel value of each of a plurality of compartments obtained by dividing the tissue along a blood flow direction.

Abstract: A vehicle air conditioning setting device functioning with a vehicle air conditioning device for setting a direction of air blown out from an air outlet and a degree of concentration and diffusion of the air is provided. The vehicle air conditioning setting device includes: a display unit that displays an air range designation image including an occupant image representing an occupant seated on a seat of the vehicle; a touch panel overlapped with the display unit; and an air range setting unit that sets an air range representing the direction of the air and the degree of concentration and diffusion of the air based on an operation range of the touch panel on the air range designation image. When a drag operation is performed on the touch panel, the air range setting unit sets the air range based on a range of the drag operation.

Abstract: In order to achieve a prediction approximating an actual change with time of a pixel value in a tissue with higher accuracy, provided is a simulator, which is configured to predict a change with time of a pixel value in a tissue of an object, including: an object information acquisition unit configured to acquire information on the object; a protocol acquisition unit configured to acquire an injection protocol for a contrast medium; a tissue information acquisition unit configured to acquire information on the tissue; and a prediction unit configured to predict, based on the information on the object, the injection protocol, and the information on the tissue, a change with time of a pixel value of each of a plurality of compartments obtained by dividing the tissue along a blood flow direction.

Abstract: A vehicle air condition display device used together with a vehicle air-conditioning apparatus includes a display unit and a display controller. The vehicle air-conditioning apparatus is capable of adjusting a direction of an air blown out from an outlet port in response to an operation made on an operation portion located away from the outlet port, and has a mechanism for adjusting a direction of the air blown out from the outlet port. The mechanism is located on upstream of the outlet port in a flow path of the air. The vehicle air condition display device includes a display unit disposed at a visually recognizable position from a driver's seat in a vehicle compartment and a display controller displaying a direction of the air blown out from the outlet port on the display unit.

Abstract: The simulator includes a chemical liquid information acquisition section configured to acquire an amount of contrast medium, a target value acquisition section configured to acquire a target duration for which a target pixel value is maintained, a protocol acquisition section configured to acquire a contrast medium injection protocol, and a prediction section for determining a predicted duration, the prediction section configured to simulate the time-dependent change in the pixel value in the tissue of the subject based on the injection protocol and the amount of the contrast medium, and the prediction section compares the predicted duration with the target duration to re-simulate, in a case where the predicted duration is shorter than the target duration, the time-dependent change in a condition where a greater amount of the contrast medium than the amount of the contrast medium used in the simulation is injected to redetermine the predicted duration, and in a case where the predicted duration is longer than

Abstract: In a display-object information displaying apparatus, each display object predetermined as a detection target is detected from image data captured by a front capture apparatus to capture of the front of a vehicle. A recognition failure probability that the driver fails to recognize each display object is evaluated. A memory saves the recognition failure probability and display object data containing display-object information with respect to each display object. A display unit displays the display-object information based on the corresponding display object data saved in the memory with respect to each display object. The display-object information about the display object assigned the higher recognition failure probability is displayed preferentially among the display objects corresponding to the display object data saved in the memory.

Abstract: In a vehicle, positional information of the vehicle and status determination information are serially acquired. Each time a user speaks a speech, speech data is acquired. A storage section stores the acquired speech data, and the positional information and status determination information acquired when the speech data is acquired, in association in a memory, as stored speech data, stored positional information, and stored status determination information. For each stored speech data in the memory, a determination is made whether a first status indicated by the stored positional information and stored status determination information associated with the stored speech data is similar to a second status indicated by the positional information and status determination information newly acquired at a current time. A reporting processor reports, to a driver, information based on the stored speech data when the determination is affirmed.

Abstract: A vehicle air condition display device used together with a vehicle air-conditioning apparatus includes a display unit and a display controller. The vehicle air-conditioning apparatus is capable of adjusting a direction of an air blown out from an outlet port in response to an operation made on an operation portion located away from the outlet port, and has a mechanism for adjusting a direction of the air blown out from the outlet port. The mechanism is located on upstream of the outlet port in a flow path of the air. The vehicle air condition display device includes a display unit disposed at a visually recognizable position from a driver's seat in a vehicle compartment and a display controller displaying a direction of the air blown out from the outlet port on the display unit.

Abstract: A vehicle air conditioning setting device functioning with a vehicle air conditioning device for setting a direction of air blown out from an air outlet and a degree of concentration and diffusion of the air is provided. The vehicle air conditioning setting device includes: a display unit that displays an air range designation image including an occupant image representing an occupant seated on a seat of the vehicle; a touch panel overlapped with the display unit; and an air range setting unit that sets an air range representing the direction of the air and the degree of concentration and diffusion of the air based on an operation range of the touch panel on the air range designation image. When a drag operation is performed on the touch panel, the air range setting unit sets the air range based on a range of the drag operation.

Abstract: In order to achieve a prediction approximating an actual change with time of a pixel value in a tissue with higher accuracy, provided is a simulator, which is configured to predict a change with time of a pixel value in a tissue of an object, including: an object information acquisition unit configured to acquire information on the object; a protocol acquisition unit configured to acquire an injection protocol for a contrast medium; a tissue information acquisition unit configured to acquire information on the tissue; and a prediction unit configured to predict, based on the information on the object, the injection protocol, and the information on the tissue, a change with time of a pixel value of each of a plurality of compartments obtained by dividing the tissue along a blood flow direction.

Abstract: In a display-object information displaying apparatus, each display object predetermined as a detection target is detected from image data captured by a front capture apparatus to capture of the front of a vehicle. A recognition failure probability that the driver fails to recognize each display object is evaluated. A memory saves the recognition failure probability and display object data containing display-object information with respect to each display object. A display unit displays the display-object information based on the corresponding display object data saved in the memory with respect to each display object. The display-object information about the display object assigned the higher recognition failure probability is displayed preferentially among the display objects corresponding to the display object data saved in the memory.

Abstract: In a vehicle, positional information of the vehicle and status determination information are serially acquired. Each time a user speaks a speech, speech data is acquired. A storage section stores the acquired speech data, and the positional information and status determination information acquired when the speech data is acquired, in association in a memory, as stored speech data, stored positional information, and stored status determination information. For each stored speech data in the memory, a determination is made whether a first status indicated by the stored positional information and stored status determination information associated with the stored speech data is similar to a second status indicated by the positional information and status determination information newly acquired at a current time. A reporting processor reports, to a driver, information based on the stored speech data when the determination is affirmed.

Abstract: The present invention is to provide a weather-resistant adhesive which achieves adhesive property, moist heat resistance and weather resistance in a practical level by means of aging at low temperature and for short time. There is provided a weather-resistant adhesive composition, characterized in containing (A) a polyester polyol having an acid value of 30 to 150 equivalents/106 g and (B) a polyisocyanate compound comprising an aliphatic polyisocyanate compound and/or an alicyclic polyisocyanate compound. Also, there is provided a layered product, characterized in being prepared by laminating films using said composition.

Abstract: The present invention is to provide a weather-resistant adhesive which achieves adhesive property, moist heat resistance and weather resistance in a practical level by means of aging at low temperature and for short time. There is provided a weather-resistant adhesive composition, characterized in containing (A) a polyester polyol having an acid value of 30 to 150 equivalents/106 g and (B) a polyisocyanate compound comprising an aliphatic polyisocyanate compound and/or an alicyclic polyisocyanate compound. Also, there is provided a layered product, characterized in being prepared by laminating films using said composition.

Abstract: Compound represented by formula (1) or a pharmaceutically acceptable solvate thereof, useful for treating or preventing Paget's disease of bone, hypercalcaemia, osteoporosis or asthma. (1) R1 represents a C1-C6 alkyl group or C7-C15 aralkyl group (the aromatic ring of which can be substituted by a C1-C6 alkyl group, C1-C6 alkoxy group, a hydroxyl group, a halogenatom or a trifluoromethyl group), R2 represents a C1-C6 alkyl group, and R3 represents a C1-C6 alkyl or alkoxy group, which can be substituted with a hydroxyl group.

Abstract: A tyrosinase activity inhibitor and an ameliorant for facial blood flow that are excellent in terms of safety, and medicinal compositions, food compositions, and cosmetic preparations that contain the inhibitor and the ameliorant as active ingredients are provided. A tyrosinase activity inhibitor and an ameliorant for facial blood flow that contain anthocyan obtained by concentration or extraction of plant material, and medicinal compositions, food compositions, and cosmetic preparations that have an inhibitory action on tyrosinase activity and ameliorating action on facial blood flow are provided.

Abstract: The present invention provides a photocatalyst material, which can comprise a photocatalyst with an excellent adherence to a substrate and a high photocatalytic activity, and a production method thereof. The photocatalyst material (20) obtained by reacting crystal nuclei with a sol solution containing an organic metallic compound or the like and then carrying out gelation, solidification and heat treatment has a structure where more than one basic structures (10) are fixed to the surface of the substrate (1). The basic structure consists of abase portion (2) comprising crystal nuclei fixed to the surface of the substrate (1) and a photocatalyst crystalline body (3), which connects to and is extended from the base portion (2) and has a columnar structure having a hollow portion (5) formed therein. A cylindrical substrate may be used for the substrate (1). The above photocatalytic activity is further enhanced by the formation of an interior-exposing structure (8) in a shell portion (4).

Abstract: A liquid crystal display apparatus includes a liquid crystal panel having a matrix of pixels, a control circuit, and a temperature sensor. The temperature sensor directly or indirectly detects a temperature of the liquid crystal panel. The control circuit reverses a polarity of a voltage applied to each pixel at a time interval variable with the detected temperature, while keeping a field frequency constant. The time interval is a positive integer multiple of the reciprocal of a field frequency, i.e., a positive integer multiple of a field period. When the temperature of the liquid crystal layer is low, the control circuit reverses the polarity of the voltage at a longer time interval. In contrast, when the temperature of the liquid crystal layer is high, the control circuit reverses the polarity of the voltage at a shorter time interval.