Patents by Inventor Yulan C. Tong
Yulan C. Tong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5493024Abstract: 3,4,N-triaryl-4,5-dihydro-1H-pyrazole-1-carboxamide compounds having an aryl moiety in the 4-position that is an optionally substituted pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or quinolinyl moiety and aryl moieties in the 3-position and the N-position that are optionally substituted phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or quinolinyl moieties, such as N-(4-chlorophenyl)-4,5-dihydro-3-(4-fluorophenyl)-4-(5-trifluoromethyl-2-p yridinyl)-1H-pyrazole-1-carboxamide, were prepared and found to possess insecticidal utility. 1,2-Diarylethanone compounds were converted to 1,2-diaryl-2-propen-1-one compounds by treatment with bis(dimethylamino)methane, the 1,2-diaryl-2-propen-1-one compounds were converted to 3,4-diaryl-4,5-dihydro-1H-pyrazole compounds by treatment with hydrazine, and the 3,4-diaryl-4,5-dihydro-1H-pyrazole compounds were converted to the insecticidal subject compounds by treatment with an aryl isocyanate.Type: GrantFiled: June 2, 1993Date of Patent: February 20, 1996Assignee: DowElancoInventors: Kevin L. McLaren, Mark B. Hertlein, James T. Pechacek, Michael J. Ricks, Yulan C. Tong
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Patent number: 5418247Abstract: 3,4,N-Trisubstituted-4,5-dihydro-1H-pyrazole-1-carboxamide compounds wherein the substituent in the 4-position is a 5-membered heterocyclic ring moiety containing one ring oxygen or sulfur atom and one or two ring nitrogen atoms and the substituents in the 3-posit ion and the N-position are optionally substituted phenyl moieties, such as 4,5-dihydro-3-(4-fluorophenyl)-N-(4-trifluoromethylphenyl)-4-(2-trifluorom ethyl-5-thiazolyl)-1H-pyrazole-1-carboxamide were prepared from appropriate 3,4-disubstituted-4,5-dihydro-1H-pyrazole compounds, such as 4,5-dihydro-3-(4-fluorophenyl)-4-(2-trifluoromethyl-5-thiazolyl)-1H-pyrazo le and phenyl is ocyanates and isothiocyanates, such as 4-(trifluoromethyl)phenyl isocyanate. The compounds are insecticidal.Type: GrantFiled: October 14, 1993Date of Patent: May 23, 1995Assignee: DowElancoInventors: Michael J. Ricks, Yulan C. Tong
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Patent number: 5338856Abstract: 3,4,N-Trisubstituted-4,5-dihydro-1H-pyrazole-1-carboxamide compounds wherein the substituent in the 4-position is a 5-membered heterocyclic ring moiety containing one ring oxygen or sulfur atom and one or two ring nitrogen atoms and the substituents in the 3-position and the N-position are optionally substituted phenyl moieties, such as 4,5-dihydro-3-(4-fluorophenyl)-N-(4-trifluoromethylphenyl)-4-(2-trifluorom ethyl-5-thiazolyl)-1H-pyrazole-1-carboxamide were prepared from appropriate 3,4-disubstituted-4,5-dihydro-1H-pyrazole compounds, such as 4,5-dihydro-3-(4-fluorophenyl)-4-(2-trifluoromethyl-5-thiazolyl)-1H-pyrazo le and phenyl isocyanates and isothiocyanates, such as 4-(trifluoromethyl)phenyl isocyanate. The compounds are insecticidal.Type: GrantFiled: August 17, 1992Date of Patent: August 16, 1994Assignee: DowElancoInventors: Michael J. Ricks, Yulan C. Tong
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Patent number: 5324837Abstract: 3,4-Diaryl-4,5-dihydro-1H-pyrazole compounds having a selected 5- or 6-membered aromatic heterocyclic moiety in the 4-position and an optionally substituted phenyl moiety in the 3-position, such as 4,5-dihydro-3-(4-fluorophenyl)-4-(5-trifluoromethyl-2-pyridinyl)-1H-pyrazo le were prepared as intermediates in the preparation of insecticidal 3,4,N-triaryl-4,5-dihydro-1H-pyrazole-1-carboxamide compounds. The 3,4-diaryl-4,5-dihydro-1H-pyrazole compounds can be prepared from appropriate 1,2-diarylethanone compounds by successive treatments with N,N,N',N'-tetramethyldiaminomethane in dichloromethane in the presence of acetic anhydride (to form a Mannich adduct) and hydrazine in the presence of a catalytic amount of trifluoroacetic acid.Type: GrantFiled: August 17, 1992Date of Patent: June 28, 1994Assignee: DowElancoInventors: James M. Renga, Kevin L. McLaren, James T. Pechacek, Michael J. Ricks, Yulan C. Tong
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Patent number: 5250532Abstract: 3,4,N-triaryl-4,5-dihydro-1H-pyrazole-1-carboxamide compounds having an aryl moiety in the 4-position that is an optionally substituted pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or quinolinyl moiety and aryl moieties in the 3-position and the N-position that are optionally substituted phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or quinolinyl moieties, such as N-(4-chlorophenyl)-4,5- -dihydro-3-(4-fluorophenyl)-4-(5-trifluoromethyl-2- -pyridinyl)-1H-pyrazole-1-carboxamide, were prepared and found to possess insecticidal utility. 1,2-Diarylethanone compounds were converted to 1,2-diaryl-2-propen-1-one compounds by treatment with bis(dimethylamino)methane, the 1,2-diaryl-2-propen-1-one compounds were converted to 3,4-diaryl-4,5-dihydro-1H-pyrazole compounds by treatment with hydrazine, and the 3,4-diaryl-4,5-dihydro-1H-pyrazole compounds were converted to the insecticidal subject compounds by treatment with an aryl isocyanate.Type: GrantFiled: February 27, 1992Date of Patent: October 5, 1993Assignee: DowElancoInventors: Kevin L. McLaren, Mark B. Hertlein, James T. Pechacek, Michael J. Ricks, Yulan C. Tong, Laura L. Karr
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Patent number: 5171743Abstract: Substituted 1,3-dithiolo- and 1,4-dithiino-pyridines are prepared which correspond to the formula: ##STR1## wherein X represents: ##STR2## These compounds have been found to exhibit antimicrobial activity in industrial and commercial applications and compositions containing these compounds are so employed.Type: GrantFiled: December 20, 1991Date of Patent: December 15, 1992Assignee: The Dow Chemical CompanyInventor: Yulan C. Tong
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Patent number: 4558134Abstract: Substituted pyridines exhibiting antiviral activity are disclosed. Also disclosed are methods of use involving the substituted pyridines as well as compositions comprising a non-toxic, pharmaceutically-acceptable carrier in combination with one or more said substituted pyridines.Type: GrantFiled: January 3, 1983Date of Patent: December 10, 1985Assignee: The Dow Chemical CompanyInventor: Yulan C. Tong
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Patent number: 4505929Abstract: Novel compounds exhibiting antiviral activity are disclosed, such compounds are represented by the formula: ##STR1## wherein m represents the integer 0, 1 or 2; R represents trihalomethyl, alkyl or phenyl; R.sub.1 represents hydrogen, bromo, chloro, fluoro, cyano, nitro, amino, alkyl, alkoxy or trifluoromethyl; R.sub.2 represents hydroxyl, bromo, chloro, fluoro, cyano, acetyl, benzoyl, substituted benzoyl, alkyl, alkoxy, substituted alkoxy, benzyl, substituted benzyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, or the radical --O(CH.sub.2).sub.n R.sub.4 wherein n represents the integer 1, 2 or 3 and R.sub.4 represents cyano or dialkylamino; R.sub.3 represents hydrogen, hydroxyl, bromo, chloro, fluoro, cyano, acetyl, benzoyl, substituted benzoyl, alkyl, alkoxy, substituted alkoxy, benzyl, substituted benzyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, or the radical --O(CH.sub.2).sub.n R.sub.Type: GrantFiled: August 16, 1982Date of Patent: March 19, 1985Assignee: The Dow Chemical CompanyInventors: Lowell D. Markley, Yulan C. Tong, Steven G. Wood
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Patent number: 4479958Abstract: Methods and compositions for inhibiting herpes virus on living or non-living substrates by use of various pyridinyl ketones or a pharmaceutically-acceptable salt thereof.Type: GrantFiled: September 13, 1978Date of Patent: October 30, 1984Assignee: The Dow Chemical CompanyInventor: Yulan C. Tong
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Patent number: 4371537Abstract: Sulfur-substituted phenoxypyridines having antiviral activity are disclosed. Methods of using the sulfur-substituted phenoxypyridines to employ their antiviral activity are also disclosed as well as pharmaceutically-acceptable compositions thereof.Type: GrantFiled: August 13, 1981Date of Patent: February 1, 1983Assignee: The Dow Chemical CompanyInventors: Lowell D. Markley, Yulan C. Tong, Steven G. Wood
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Patent number: 4349568Abstract: Novel compounds exhibiting antiviral activity are disclosed, such compounds are represented by the formula: ##STR1## wherein m represents the integer 0, 1 or 2; R represents trihalomethyl, alkyl or phenyl; R.sub.1 represents hydrogen, bromo, chloro, fluoro, cyano, nitro, amino, alkyl, alkoxy or trifluoromethyl; R.sub.2 represents hydroxyl, bromo, chloro, fluoro, cyano, acetyl, benzoyl, substituted benzoyl, alkyl, alkoxy, substituted alkoxy, benzyl, substituted benzyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, or the radical --O(CH.sub.2).sub.n R.sub.4 wherein n represents the integer 1, 2 or 3 and R.sub.4 represents cyano or dialkylamino; R.sub.3 represents hydrogen, hydroxyl, bromo, chloro, fluoro, cyano, acetyl, benzoyl, substituted benzoyl, alkyl, alkoxy, substituted alkoxy, benzyl, substituted benzyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, or the radical --O(CH.sub.2).sub.n R.sub.Type: GrantFiled: June 12, 1980Date of Patent: September 14, 1982Assignee: The Dow Chemical CompanyInventors: Lowell D. Markley, Yulan C. Tong, Steven G. Wood
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Patent number: 4108859Abstract: Acid salts of N,N'-dialkyl-N"-(substituted pyridyl)aminoalkylguanidines constitute a novel class of compounds having good microbicidal activity, particularly against microorganisms which attack paints. These guanidines are prepared by reacting corresponding N-(chloropyridyl)alkanediamines with N,N'-dialkyl-S-ethylthiouronium iodide in an inert, polar solvent.Type: GrantFiled: June 6, 1977Date of Patent: August 22, 1978Assignee: The Dow Chemical CompanyInventor: Yulan C. Tong
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Patent number: 4075207Abstract: Thiazolopyrazines having growth inhibitory activity against microorganisms are of the formula ##STR1## wherein X is --Br, --Cl or F and R is --H or --CH.sub.3-x Y.sub.x, Y is --Br, --Cl, or F and x is 0, 1, 2 or 3. These compounds also have utility as intermediates for the preparation of three-ring compounds which are highly active against microorganisms.Type: GrantFiled: February 17, 1977Date of Patent: February 21, 1978Assignee: The Dow Chemical CompanyInventor: Yulan C. Tong
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Patent number: 3987044Abstract: Insoluble association products are formed when solid 2,3-diamino-5,6-dihalopyrazines are contacted with liquid ketones of the structure R.sup.1 --CH.sub.2 --CO--CH.sub.2 --R.sup.2, wherein R.sup.1 and R.sup.2 are both H or together constitute a polymethylene chain of from 2 to 4 carbons. The isomeric 2,6-diamino-dihalopyrazines dissolve in the ketones. Thus, mixtures of the solid 2,3-diamino-dihalopyrazines with their isomers and/or other ketone-soluble materials can be resolved by contacting the mixtures with ketones of the preceding structure and separating the resultant solid and liquid phases. The association products constitute a novel composition of matter.Type: GrantFiled: August 18, 1975Date of Patent: October 19, 1976Assignee: The Dow Chemical CompanyInventor: Yulan C. Tong