Patents by Inventor Yulia Sevryugina

Yulia Sevryugina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BORON CLUSTER COMPOUNDS AND USES THEREOF
    Publication number: 20190135838
    Abstract: The present invention relates to novel boron cluster compounds and their use as sodium channel blockers. The invention also provides methods for making and using the compounds.
    Type: Application
    Filed: January 3, 2019
    Publication date: May 9, 2019
    Applicant: The Curators of the University of Missouri
    Inventors: George R. Kracke, Yulia Sevryugina, Marion Frederick Hawthorne
  • Boron cluster compounds and uses thereof
    Patent number: 10202406
    Abstract: The present invention relates to novel cluster boron compounds and their use as sodium channel blockers. The invention also provides methods for making and using the compounds.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: February 12, 2019
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: George R. Kracke, Yulia Sevryugina, Marion Frederick Hawthorne
  • Small molecule inhibitors of nicotinamide phosphoribosyltransferase (NAMPT)
    Patent number: 9382267
    Abstract: The present invention relates to novel compounds, their use as anti-cancer agents and their synthesis. In particular, the compounds contain cluster boron moieties such as carborane or a borohydride and act as inhibitors for the enzyme Nampt. The biological properties of the inventive cluster boron compounds, in terms of biological inhibition and antiproliferative effect, are greater than other small molecule inhibitors of Nampt.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: July 5, 2016
    Assignee: The Curators of the University of Missouri
    Inventors: Mark Wayne Lee, Jr., Yulia Sevryugina
  • CLUSTER BORON COMPOUNDS AND USES THEREOF
    Publication number: 20160031912
    Abstract: The present invention relates to novel cluster boron compounds and their use as sodium channel blockers. The invention also provides methods for making and using the compounds.
    Type: Application
    Filed: August 18, 2015
    Publication date: February 4, 2016
    Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: George R. Kracke, Yulia Sevryugina, Marion Frederick Hawthorne
  • Cluster boron compounds and uses thereof
    Patent number: 9217002
    Abstract: The present invention relates to novel cluster boron compounds and their use as sodium channel blockers. In particular, the novel cluster boron compounds may be lidocaine analogs where the aromatic ring of the lidocaine molecule is replaced with a cluster boron group. The invention also provides methods for making the cluster boron compounds comprising contacting a halogenated cluster boron with an amino acetamide in the presence of a catalyst, a proton acceptor, and a ligand.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: December 22, 2015
    Assignee: The Curators of the University of Missouri
    Inventors: George R. Kracke, Yulia Sevryugina, Marion Frederick Hawthorne
  • SMALL MOLECULE INHIBITORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)
    Publication number: 20150322093
    Abstract: The present invention relates to novel compounds, their use as anti-cancer agents and their synthesis. In particular, the compounds contain cluster boron moieties such as carborane or a borohydride and act as inhibitors for the enzyme Nampt. The biological properties of the inventive cluster boron compounds, in terms of biological inhibition and antiproliferative effect, are greater than other small molecule inhibitors of Nampt.
    Type: Application
    Filed: November 28, 2012
    Publication date: November 12, 2015
    Inventors: Mark Wayne Lee, Jr., Yulia Sevryugina
  • CLUSTER BORON COMPOUNDS AND USES THEREOF
    Publication number: 20150072956
    Abstract: The present invention relates to novel cluster boron compounds and their use as sodium channel blockers. In particular, the novel cluster boron compounds may be lidocaine analogs where the aromatic ring of the lidocaine molecule is replaced with a cluster boron group. The invention also provides methods for making the cluster boron compounds comprising contacting a halogenated cluster boron with an amino acetamide in the presence of a catalyst, a proton acceptor, and a ligand.
    Type: Application
    Filed: September 13, 2012
    Publication date: March 12, 2015
    Applicant: The Curators of the University of Missouri
    Inventors: George R. Kracke, Yulia Sevryugina, Marion Frederick Hawthorne